scholarly journals Lighting the way: advances in transcriptional regulation and integrative crosstalk of melatonin biosynthetic enzymes in cassava

2020 ◽  
Author(s):  
Yunxie Wei ◽  
Yujing Bai ◽  
Xiao Cheng ◽  
Russel J Reiter ◽  
Xiaojian Yin ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Transcriptional Regulation ◽  
Signaling Pathways ◽  
Stress Responses ◽  
Protein Complex ◽  
Recent Progress ◽  
Biosynthetic Enzymes ◽  
Dual Roles ◽  
Melatonin Synthesis

Abstract The role of melatonin biosynthetic enzymes has been well studied. However, the transcriptional regulation of melatonin biosynthetic enzymes and their integrative crosstalk with other signaling pathways remain elusive. Here, we summarize recent progress in the functional analysis of melatonin biosynthetic enzymes and the major sites of melatonin synthesis in plants. We focus on the dual roles of melatonin biosynthetic enzymes in melatonin biosynthesis and in the crosstalk between melatonin and autophagy, antioxidant signaling, and stress responses in cassava. We highlight the transcriptional regulation and integrative protein complex of melatonin biosynthetic enzymes, and then raise the challenge of uncovering their precise regulation and crosstalk.

scholarly journals Role of N6-Methyladenosine RNA Modification in Cardiovascular Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Dandan Song ◽  
Jianhua Hou ◽  
Junduo Wu ◽  
Junnan Wang
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Transcriptional Regulation ◽  
Recent Progress ◽  
Rna Modification ◽  
Non Coding Rnas ◽  
Post Transcriptional Regulation

Despite treatments being improved and many risk factors being identified, cardiovascular disease (CVD) is still a leading cause of mortality and disability worldwide. N6-methyladenosine (m6A) is the most common, abundant, and conserved internal modification in RNAs and plays an important role in the development of CVD. Many studies have shown that aabnormal m6A modifications of coding RNAs are involved in the development of CVD. In addition, non-coding RNAs (ncRNAs) exert post-transcriptional regulation in many diseases including CVD. Although ncRNAs have also been found to be modified by m6A, the studies on m6A modifications of ncRNAs in CVD are currently lacking. In this review, we summarized the recent progress in understanding m6A modifications in the context of coding RNAs and ncRNAs, as well as their regulatory roles in CVD.

scholarly journals A functional analysis to dissect the role of ROS signaling pathways using chemogenetic tools and genetically encoded biosensors for in vitro studies

2021 ◽  
Vol 165 ◽  
pp. 17
Author(s):  
Yusuf Ceyhun Erdoğan ◽  
Serap Sezen ◽  
Büşra Nur Ata ◽  
Zeynep Çokluk ◽  
Melike Seçilmiş ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Signaling Pathways ◽  
In Vitro Studies ◽  
Ros Signaling

The role of ABA and MAPK signaling pathways in plant abiotic stress responses

2014 ◽  
Vol 32 (1) ◽  
pp. 40-52 ◽  
Author(s):  
Agyemang Danquah ◽  
Axel de Zelicourt ◽  
Jean Colcombet ◽  
Heribert Hirt
Keyword(s):  
Abiotic Stress ◽  
Signaling Pathways ◽  
Stress Responses ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways ◽  
Plant Abiotic Stress

scholarly journals The role of collagen in cancer: from bench to bedside

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Shuaishuai Xu ◽  
Huaxiang Xu ◽  
Wenquan Wang ◽  
Shuo Li ◽  
Hao Li ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Cell Activity ◽  
Dual Roles ◽  
Discoidin Domain Receptors ◽  
Other Substances ◽  
Tumor Cell Behavior ◽  
New Strategies

Abstract Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. Exosomes and microRNAs are closely associated with collagen in cancer. Hypoxia, which is common in collagen-rich conditions, intensifies cancer progression, and other substances in the extracellular matrix, such as fibronectin, hyaluronic acid, laminin, and matrix metalloproteinases, interact with collagen to influence cancer cell activity. Macrophages, lymphocytes, and fibroblasts play a role with collagen in cancer immunity and progression. Microscopic changes in collagen content within cancer cells and matrix cells and in other molecules ultimately contribute to the mutual feedback loop that influences prognosis, recurrence, and resistance in cancer. Nanoparticles, nanoplatforms, and nanoenzymes exhibit the expected gratifying properties. The pathophysiological functions of collagen in diverse cancers illustrate the dual roles of collagen and provide promising therapeutic options that can be readily translated from bench to bedside. The emerging understanding of the structural properties and functions of collagen in cancer will guide the development of new strategies for anticancer therapy.

scholarly journals Structural and Functional Analysis of the GRAS Gene Family in Grapevine Indicates a Role of GRAS Proteins in the Control of Development and Stress Responses

2016 ◽  
Vol 7 ◽  
Author(s):  
Jérôme Grimplet ◽  
Patricia Agudelo-Romero ◽  
Rita T. Teixeira ◽  
Jose M. Martinez-Zapater ◽  
Ana M. Fortes
Keyword(s):  
Functional Analysis ◽  
Gene Family ◽  
Stress Responses ◽  
Gras Gene

Dual Role of RKIP in NF-kB Signaling Pathways

2011 ◽  
Vol 2 (1) ◽  
pp. 21-34
Author(s):  
Huihui Tang ◽  
Sungdae Park ◽  
Kam C. Yeung
Keyword(s):  
Signaling Pathways ◽  
Dual Role

Magnetic Properties of xCeO2•(50 − x) PbO•50B2O3 Glasses and Glass Ceramics

2017 ◽  
Vol 13 (1) ◽  
pp. 4486-4494 ◽  
Author(s):  
G.El Damrawi ◽  
F. Gharghar
Keyword(s):  
Magnetic Properties ◽  
Large Scale ◽  
Glass Ceramics ◽  
Magnetic Behavior ◽  
Crystal Formation ◽  
Dual Roles ◽  
Effective Agent ◽  
Ordered Structures ◽  
Essential Change

Cerium oxide in borate glasses of composition xCeO2·(50 − x)PbO·50B2O3 plays an important role in changing both microstructure and magnetic behaviors of the system. The structural role of CeO2 as an effective agent for cluster and crystal formation in borate network is clearly evidenced by XRD technique. Both structure and size of well-formed cerium separated clusters have an effective influence on the structural properties. The cluster aggregations are documented to be found in different range ordered structures, intermediate and long range orders are the most structures in which cerium phases are involved. The nano-sized crystallized cerium species in lead borate phase are evidenced to have magnetic behavior.  The criteria of building new specific borate phase enriched with cerium as ferrimagnetism has been found to keep the magnetization in large scale even at extremely high temperature. Treating the glass thermally or exposing it to an effective dose of ionized radiation is evidenced to have an essential change in magnetic properties. Thermal heat treatment for some of investigated materials is observed to play dual roles in the glass matrix. It can not only enhance alignment processes of the magnetic moment but also increases the capacity of the crystallite species in the magnetic phases. On the other hand, reverse processes are remarked under the effect of irradiation. The magnetization was found to be lowered, since several types of the trap centers which are regarded as defective states can be produced by effect of ionized radiation. 

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