A case of acute generalized exanthematous pustulosis caused by exposure to Atovaquone/proguanil

2020 ◽  
Vol 27 (6) ◽  
Author(s):  
Marta Arsuaga ◽  
Rosa de Miguel ◽  
Elena Trigo ◽  
Pablo Barreiro ◽  
Fernando de la Calle ◽  
...  
Keyword(s):  
Adverse Events ◽  
Steroid Treatment ◽  
Allergy Testing ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Medical Evaluation ◽  
Severe Adverse Events ◽  
Exanthematous Pustulosis

We present a returning traveler with acute generalized exanthematous pustulosis after atovaquone/proguanil prophylaxis. Diagnosis was confirmed with biopsy and allergy testing, symptoms resolved after steroid treatment. Atovaquone/proguanil prophylaxis is generally well tolerated, however, some patients may present severe adverse events that require prompt medical evaluation and treatment.

scholarly journals Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis

2017 ◽  
Vol 9 (1) ◽  
pp. 135-139 ◽  
Author(s):  
Christiane Kley ◽  
Carla Murer ◽  
Julia-Tatjana Maul ◽  
Barbara Meier ◽  
Florian Anzengruber ◽  
...  
Keyword(s):  
Topical Steroid ◽  
Steroid Treatment ◽  
Clobetasol Propionate ◽  
Topical Steroids ◽  
First Line ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Cutaneous Adverse Reaction ◽  
Amoxicillin Clavulanic Acid ◽  
Diffuse Erythema ◽  
Exanthematous Pustulosis

Acute generalized exanthematous pustulosis (AGEP) is a dramatic generalized pustular rash of severe onset, which is considered a serious cutaneous adverse reaction to drugs. However, even though the clinical features are impressive and are often accompanied by systemic inflammation, it can be controlled quickly and safely by topical steroids subsequent to interruption of the offending drug. Here, we describe the management of a case and the evolution of the pustular rash. An elderly woman consulted with a generalized crop of 2–3 mm, nonfollicular pustules on erythematous background. In the 4 preceding weeks, she had been using amoxicillin/clavulanic acid for a bacterial implant infection and rivaroxaban. The clinical EuroSCAR criteria including the histology confirmed AGEP. Her medication was stopped and topical clobetasol propionate was used. Within 24 h, the development of new pustules ceased and the patient was discharged after 7 days of hospitalization with only a faint, diffuse erythema and focal desquamation remaining. This and many other cases in the literature suggest that topical steroids should be considered as a first-line treatment option, especially as systemic steroids themselves can sometimes induce generalized pustulosis.

Enzalutamide induced acute generalized exanthematous pustulosis

2016 ◽  
Vol 10 (2) ◽  
Author(s):  
Chloé Alberto ◽  
Maria Polina Konstantinou ◽  
Catherine Martinage ◽  
Eline Casassa ◽  
Emilie Tournier ◽  
...  
Keyword(s):  
Acute Generalized Exanthematous Pustulosis ◽  
Exanthematous Pustulosis

A Case of Acute Generalized Exanthematous Pustulosis in a Puerpera.

2000 ◽  
Vol 62 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Maiko YOKOYAMA ◽  
Tatsuro TANAKA ◽  
Yutaka NARISAWA
Keyword(s):  
Acute Generalized Exanthematous Pustulosis ◽  
Exanthematous Pustulosis
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