scholarly journals Relationship Between Mammographic Density and Breast Cancer Death in the Breast Cancer Surveillance Consortium

2012 ◽  
Vol 104 (16) ◽  
pp. 1218-1227 ◽  
Author(s):  
Gretchen L. Gierach ◽  
Laura Ichikawa ◽  
Karla Kerlikowske ◽  
Louise A. Brinton ◽  
Ghada N. Farhat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammographic Density ◽  
Cancer Surveillance ◽  
Cancer Death ◽  
Breast Cancer Death ◽  
Breast Cancer Surveillance Consortium

scholarly journals Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium

2020 ◽  
Author(s):  
Karla Kerlikowske ◽  
Michael C S Bissell ◽  
Brian L Sprague ◽  
Diana S M Buist ◽  
Louise M Henderson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Advanced Cancer ◽  
Operating Characteristic ◽  
Cancer Surveillance ◽  
Cancer Death ◽  
Breast Cancer Death ◽  
Pathologic Stage ◽  
Breast Cancer Surveillance Consortium ◽  
Screening Effectiveness

Abstract Background Advanced breast cancer is an outcome used to evaluate screening effectiveness. The advanced cancer definition resulting in the best discrimination of breast cancer death has not been studied in a breast imaging population. Methods A total of 52 496 women aged 40-79 years participating in the Breast Cancer Surveillance Consortium diagnosed with invasive cancer were staged using the 8th edition of American Joint Committee on Cancer (AJCC) anatomic and prognostic pathologic systems and Tomosynthesis Mammographic Imaging Screening Trial (TMIST) tumor categories. We calculated the area under the receiver operating characteristic curve for predicting 5-year breast cancer death and the sensitivity and specificity for predicting 5-year breast cancer death for 3 advanced cancer classifications: anatomic stage IIB or higher, prognostic pathologic stage IIA or higher, and TMIST advanced cancer. Results The area under the receiver operating characteristic curves for predicting 5-year breast cancer death for AJCC anatomic stage, AJCC prognostic pathologic stage, and TMIST tumor categories were 0.826 (95% confidence interval [CI] = 0.817 to 0.835), 0.856 (95% CI = 0.846 to 0.866), and 0.789 (95% CI = 0.780 to 0.797), respectively. AJCC prognostic pathologic stage had statistically significantly better discrimination than AJCC anatomic stage (difference = 0.030, bootstrap 95% CI = 0.024 to 0.037) and TMIST tumor categories (difference = 0.067, bootstrap 95% CI = 0.059 to 0.075). The sensitivity and specificity for predicting 5-year breast cancer death for AJCC anatomic stage IIB or higher, AJCC prognostic pathologic stage IIA or higher, and TMIST advanced cancer were 72.6%, 76.7%, and 96.1%; and 78.9%, 81.6%, and 41.1%, respectively. Conclusions Defining advanced cancer as AJCC prognostic pathologic stage IIA or higher most accurately predicts breast cancer death. Use of this definition by investigators will facilitate comparing breast cancer screening effectiveness studies.

scholarly journals Screening Mammography Outcomes: Risk of Breast Cancer and Mortality by Comorbidity Score and Age

2019 ◽  
Vol 112 (6) ◽  
pp. 599-606 ◽  
Author(s):  
Joshua Demb ◽  
Linn Abraham ◽  
Diana L Miglioretti ◽  
Brian L Sprague ◽  
Ellen S O’Meara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Cumulative Incidence ◽  
Ductal Carcinoma ◽  
Breast Cancer Incidence ◽  
Screening Mammography ◽  
Cancer Surveillance ◽  
Breast Cancer Death ◽  
Potential Benefits ◽  
Breast Cancer Surveillance Consortium

Abstract Background Potential benefits of screening mammography among women ages 75 years and older remain unclear. Methods We evaluated 10-year cumulative incidence of breast cancer and death from breast cancer and other causes by Charlson Comorbidity Index (CCI) and age in the Medicare-linked Breast Cancer Surveillance Consortium (1999–2010) cohort of 222 088 women with no less than 1 screening mammogram between ages 66 and 94 years. Results During median follow-up of 107 months, 7583 were diagnosed with invasive breast cancer and 1742 with ductal carcinoma in situ; 471 died from breast cancer and 42 229 from other causes. The 10-year cumulative incidence of invasive breast cancer did not change with increasing CCI but decreased slightly with age: ages 66–74 years (CCI0 = 4.0% [95% CI = 3.9% to 4.2%] vs CCI  ≥ 2 = 3.9% [95% CI = 3.5% to 4.3%]); ages 75–84 years (CCI0 = 3.7% [95% CI = 3.5% to 3.9%] vs CCI  ≥ 2 = 3.4% [95% CI = 2.9% to 3.9%]); and ages 85–94 years (CCI0 = 2.7% [95% CI = 2.3% to 3.1%] vs CCI  ≥ 2 = 2.1% [95% CI = 1.3% to 3.0%]). The 10-year cumulative incidence of other-cause death increased with increasing CCI and age: ages 66–74 years (CCI0 = 10.4% [95% CI = 10.3 to 10.7%] vs CCI ≥ 2 = 43.4% [95% CI = 42.2% to 44.4%]), ages 75–84 years (CCI0 = 29.8% [95% CI = 29.3% to 30.2%] vs CCI ≥ 2 = 61.7% [95% CI = 60.2% to 63.3%]), and ages 85 to 94 years (CCI0 = 60.3% [95% CI = 59.1% to 61.5%] vs CCI  ≥ 2 = 84.8% [95% CI = 82.5% to 86.9%]). The 10-year cumulative incidence of breast cancer death was small and did not vary by age: ages 66–74 years = 0.2% (95% CI = 0.2% to 0.3%), ages 75–84 years = 0.29% (95% CI = 0.25% to 0.34%), and ages 85 to 94 years = 0.3% (95% CI = 0.2% to 0.4%). Conclusions Cumulative incidence of other-cause death was many times higher than breast cancer incidence and death, depending on comorbidity and age. Hence, older women with increased comorbidity may experience diminished benefit from continued screening.

scholarly journals Trends in breast biopsy pathology diagnoses among women undergoing mammography in the United States: A report from the Breast Cancer Surveillance Consortium

Cancer ◽  
2015 ◽  
Vol 121 (9) ◽  
pp. 1369-1378 ◽  
Author(s):  
Kimberly H. Allison ◽  
Linn A. Abraham ◽  
Donald L. Weaver ◽  
Anna N. A. Tosteson ◽  
Heidi D. Nelson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Breast Biopsy ◽  
The United States ◽  
Cancer Surveillance ◽  
Breast Cancer Surveillance Consortium

Trends in breast cancer survival by race-ethnicity in Florida.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e18556-e18556
Author(s):  
Robert Brooks Hines ◽  
Asal Johnson ◽  
Eunkyung Lee ◽  
Stephanie Erickson ◽  
Saleh M.M. Rahman
Keyword(s):  
Breast Cancer ◽  
Ethnic Disparities ◽  
Cancer Death ◽  
Cancer Outcomes ◽  
Subdistribution Hazard ◽  
Breast Cancer Death ◽  
Breast Cancer Outcomes ◽  
Race Ethnicity ◽  
Racial Ethnic ◽  
Hispanic White

e18556 Background: Considerable efforts to improve disparities in breast cancer outcomes for underserved women have occurred over the past 3 decades. This study was conducted to evaluate trends in survival, by race-ethnicity, for women diagnosed with breast cancer in Florida over a 26-year period to assess potential improvement in racial-ethnic disparities. Methods: This was a retrospective cohort study of women diagnosed with invasive breast cancer in Florida between 1990-2015. Data were obtained from the Florida Cancer Data System. Women in the study were categorized according to race (white/black) and Hispanic ethnicity (yes/no) as non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic white (HW), and Hispanic black (HB). Cumulative incidence estimates of 5- and 10-year breast cancer death with 95% confidence intervals (CI) were obtained by race-ethnicity, according to diagnosis year. Subdistribution hazard models were used to obtain subdistribution hazard ratios (sHR) for the relative rate of breast cancer death accounting for competing causes. Results: Compared to NHW women, minority women were more likely to be younger, be uninsured or have Medicaid as health insurance, live in high poverty neighborhoods, have more advanced disease at diagnosis, have high grade tumors, have hormone receptor negative tumors, and receive chemotherapy as treatment. Minority women were less likely to receive surgery. Over the course of the study, breast cancer mortality decreased for all racial-ethnic groups, and racial-ethnic minorities had greater absolute and relative improvement in breast cancer survival for nearly all metrics compared to non-Hispanic white (NHW) women. However, for the most recent time period (2010-2015), black women still experienced significant survival disparities with non-Hispanic black (NHB) women having twice the rate of 5-year (sHR = 2.04: 95% CI; 1.91-2.19) and 10-year (sHR = 2.02: 95% CI; 1.89-2.16) breast cancer death. Conclusions: Despite efforts to improve disparities in breast cancer outcomes for underserved women in Florida, additional targeted approaches are needed to reduce the poorer survival in black (especially NHB) women. Our next step is to conduct a mediation analysis of the most important factors driving racial/ethnic disparities in breast cancer outcomes for women in Florida.

scholarly journals Upgrade of high-risk breast lesions detected on mammography in the Breast Cancer Surveillance Consortium

2014 ◽  
Vol 207 (1) ◽  
pp. 24-31 ◽  
Author(s):  
Tehillah S. Menes ◽  
Robert Rosenberg ◽  
Steven Balch ◽  
Shabnam Jaffer ◽  
Karla Kerlikowske ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Surveillance ◽  
Breast Lesions ◽  
Breast Cancer Surveillance Consortium ◽  
High Risk Breast
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