scholarly journals A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

2015 ◽  
Vol 7 (6) ◽  
pp. 517-528 ◽  
Author(s):  
Cristina Martin-Granados ◽  
Alan R. Prescott ◽  
Samantha Le Sommer ◽  
Izabela P. Klaska ◽  
Tian Yu ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cell Maturation

TREM-1 modulates dendritic cell maturation and dendritic cell–mediated T cell activation induced by ox-LDL

2020 ◽  
Author(s):  
Yunkai Wang ◽  
Jie Wang ◽  
Lu Han ◽  
Yun Li Shen ◽  
Jie Yun You ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Human Peripheral Blood ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Blood Monocytes

Abstract Background: Triggering receptor expressed on myeloid cells (TREM)-1is identified as a major upstream proatherogenic receptor. However, the cellular processes modulated by TREM-1 in the development of atherosclerosis and plaque destabilization has not been fully elucidated. In this study, we investigated the effects of TREM-1 on dendritic cell maturation and dendritic cell–mediated T-cell activation induced by oxidized low-density lipoprotein (ox-LDL) in atherogenesis. Methods: Human peripheral blood monocytes were differentiated to dendritic cells and stimulated by ox-LDL. Naive autologous T cells were co-cultured with pretreated dendritic cells.The expressionof TREM-1 and the production of inflammatory cytokines were assessed by real-time PCR, western blot and ELISA.The expression of immune factors was determined with FACS to evaluate dendritic cell maturation and T-cell activation. Results: Stimulation with ox-LDL promoted dendritic cell maturation, TREM-1 expression and T-cell activation, and exposure of T cells to ox-LDL-treated dendritic cells induced production of interferon-γ and IL-17. Blocking TREM-1 suppressed dendritic cell maturation with low expression of CD1a, CD40, CD86 and HLA-DR, decreased production of TNF-α, IL-1β, IL-6 and MCP-1, and increased secretion of TGF-β and IL-10. In addition, stimulation of ox-LDL induced miR-155, miR-27, Let-7c and miR-185 expression, whereas inhibition of TREM-1 repressed miRNA-155. Silencing TREM-1 or miRNA-155 increased SOCS1 expression induced by ox-LDL. T cells derived from carotid atherosclerotic plaques or healthy individuals showed similar result patterns. Conclusion: These data suggest that TREM-1 modulates maturation of dendritic cells and activation of plaque T cells induced by ox-LDL, a pivotal player in atherogenesis.

Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4 + T‐cell activation and dendritic cell maturation

2016 ◽  
Vol 94 (7) ◽  
pp. 689-700 ◽  
Author(s):  
Harold Oliva ◽  
Rodrigo Pacheco ◽  
José M Martinez‐Navio ◽  
Marta Rodríguez‐García ◽  
Mar Naranjo‐Gómez ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cytidine Deaminase ◽  
Subcellular Location ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation

Functionalized Polystyrene Nanoparticles Trigger Human Dendritic Cell Maturation Resulting in Enhanced CD4+T Cell Activation

2012 ◽  
Vol 12 (12) ◽  
pp. 1637-1647 ◽  
Author(s):  
Stefanie U. Frick ◽  
Nicole Bacher ◽  
Grit Baier ◽  
Volker Mailänder ◽  
Katharina Landfester ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation ◽  
Human Dendritic Cell ◽  
Polystyrene Nanoparticles

scholarly journals Enhanced Dendritic Cell Maturation by TNF-α or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo

2000 ◽  
Vol 165 (11) ◽  
pp. 6278-6286 ◽  
Author(s):  
Christoph Brunner ◽  
Julia Seiderer ◽  
Angelika Schlamp ◽  
Martin Bidlingmaier ◽  
Andreas Eigler ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Immune Responses ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cell Maturation ◽  
Tnf Α

scholarly journals Selenium affects allergic asthma by regulating CD4+ T cell activation and dendritic cell maturation

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Peter R Hoffmann ◽  
FuKun Hoffmann ◽  
Claude Jourdan‐LeSaux ◽  
Oana Bollt ◽  
Elizabeth Tam ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Allergic Asthma ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Maturation ◽  
Cd4 T Cell ◽  
Cell Maturation
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