scholarly journals Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

2012 ◽  
Vol 4 (6) ◽  
pp. 409-419 ◽  
Author(s):  
Qin Lan ◽  
Xiaohui Zhou ◽  
Huimin Fan ◽  
Maogen Chen ◽  
Julie Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Treg Cells ◽  
Murine Lupus ◽  
Tolerogenic Dendritic Cells

The priming of seminal fluid induces tolerogenic dendritic cells in allogeneic mating mice resulting in increase of paternal antigen-specific Treg cells

2016 ◽  
Vol 118 ◽  
pp. 110
Author(s):  
Akemi Ushijima ◽  
Tomoko Shima ◽  
Kumiko Inada ◽  
Akitoshi Nakashima ◽  
Osamu Yoshino ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Seminal Fluid ◽  
Treg Cells ◽  
Tolerogenic Dendritic Cells

scholarly journals The priming of seminal fluid induces tolerogenic dendritic cells in allogeneic mating mice resulting in increase of paternal antigen-specific Treg cells

2017 ◽  
Vol 32 (0) ◽  
pp. 13-20
Author(s):  
Akemi Ushijima ◽  
Tomoko Shima ◽  
Kumiko Inada ◽  
Akitoshi Nakashima ◽  
Osamu Yoshino ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Seminal Fluid ◽  
Treg Cells ◽  
Tolerogenic Dendritic Cells

HIV-Antigens Charged on Phosphorus Dendrimers as Tools for Tolerogenic Dendritic Cells-Based Immunotherapy

2014 ◽  
Vol 21 (16) ◽  
pp. 1898-1909 ◽  
Author(s):  
Enrique Vacas-Cordoba ◽  
Hugo Bastida ◽  
Marjorie Pion ◽  
Aurelien Hameau ◽  
Maksim Ionov ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tolerogenic Dendritic Cells

scholarly journals 1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications

Cytotherapy ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 242-255
Author(s):  
Kayleigh M. van Megen ◽  
Zhuo Chen ◽  
Antoinette M. Joosten ◽  
Sandra Laban ◽  
Jaap-Jan Zwaginga ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epigenetic Modifications ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Tolerogenic Dendritic Cells

Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling

2021 ◽  
Vol 70 ◽  
pp. 33-39
Author(s):  
Andreia Barroso ◽  
João V Mahler ◽  
Pedro H Fonseca-Castro ◽  
Francisco J Quintana
Keyword(s):  
Dendritic Cells ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Tolerogenic Dendritic Cells

scholarly journals Synergistic Effect of Tolerogenic Dendritic Cells and Etanercept on a Collagen-induced Arthritis Animal Model

2019 ◽  
Vol 28 (3) ◽  
pp. 265-272
Author(s):  
Sang Youn Jung ◽  
Kil-Sang Cho ◽  
Doo-Rye Jang ◽  
Jun-Ho Lee ◽  
So-Yeon Choi ◽  
...  
Keyword(s):  
Animal Model ◽  
Dendritic Cells ◽  
Synergistic Effect ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

scholarly journals Comparative study of clinical grade human tolerogenic dendritic cells

2011 ◽  
Vol 9 (1) ◽  
pp. 89 ◽  
Author(s):  
M Naranjo-Gómez ◽  
D Raïch-Regué ◽  
C Oñate ◽  
L Grau-López ◽  
C Ramo-Tello ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Comparative Study ◽  
Clinical Grade ◽  
Tolerogenic Dendritic Cells

scholarly journals Tolerogenic Splenic IDO+Dendritic Cells from the Mice Treated with Induced-Treg Cells Suppress Collagen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Jie Yang ◽  
Yiming Yang ◽  
Huahua Fan ◽  
Hejian Zou
Keyword(s):  
Dendritic Cells ◽  
Immune Responses ◽  
Foxp3 Expression ◽  
Treated Group ◽  
Treg Cells ◽  
Therapeutic Effects ◽  
Dependent Manner ◽  
Collagen Induced Arthritis

TGF-β-induced regulatory T cells (iTregs) retain Foxp3 expression and immune-suppressive activity in collagen-induced arthritis (CIA). However, the mechanisms whereby transferred iTregs suppress immune responses, particularly the interplay between iTregs and dendritic cells (DCs)in vivo, remain incompletely understood. In this study, we found that after treatment with iTregs, splenic CD11c+DCs, termed “DCiTreg,” expressed tolerogenic phenotypes, secreted high levels of IL-10, TGF-β, and IDO, and showed potent immunosuppressive activityin vitro. After reinfusion with DCiTreg, marked antiarthritic activity improved clinical scores and histological end-points were observed. The serological levels of inflammatory cytokines and anti-CII antibodies were low and TGF-βproduction was high in the DCiTreg-treated group. DCiTregalso induced new iTregsin vivo. Moreover, the inhibitory activity of DCiTregon CIA was lost following pretreatment with the inhibitor of indoleamine 2,3-dioxygenase (IDO). Collectively, these findings suggest that transferred iTregs could induce tolerogenic characteristics in splenic DCs and these cells could effectively dampen CIA in an IDO-dependent manner. Thus, the potential therapeutic effects of iTregs in CIA are likely maintained through the generation of tolerogenic DCsin vivo.

scholarly journals Protein Kinase C Inhibitor Generates Stable Human Tolerogenic Dendritic Cells

2013 ◽  
Vol 191 (5) ◽  
pp. 2247-2257 ◽  
Author(s):  
Takuya Matsumoto ◽  
Hitoshi Hasegawa ◽  
Sachiko Onishi ◽  
Jun Ishizaki ◽  
Koichiro Suemori ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Tolerogenic Dendritic Cells ◽  
Protein Kinase C Inhibitor

scholarly journals CD4+ CD25+ Foxp3+ Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host Responses?

2010 ◽  
Vol 78 (11) ◽  
pp. 4763-4772 ◽  
Author(s):  
Raquel M. Gonçalves ◽  
Karina C. Salmazi ◽  
Bianca A. N. Santos ◽  
Melissa S. Bastos ◽  
Sandra C. Rocha ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Parasite Species ◽  
Inflammatory Responses ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Surface Expression ◽  
Interleukin 10 ◽  
Treg Cells ◽  
Experimental Models ◽  
Necrosis Factor Alpha

ABSTRACT Clearing blood-stage malaria parasites without inducing major host pathology requires a finely tuned balance between pro- and anti-inflammatory responses. The interplay between regulatory T (Treg) cells and dendritic cells (DCs) is one of the key determinants of this balance. Although experimental models have revealed various patterns of Treg cell expansion, DC maturation, and cytokine production according to the infecting malaria parasite species, no studies have compared all of these parameters in human infections with Plasmodium falciparum and P. vivax in the same setting of endemicity. Here we show that during uncomplicated acute malaria, both species induced a significant expansion of CD4+ CD25+ Foxp3+ Treg cells expressing the key immunomodulatory molecule CTLA-4 and a significant increase in the proportion of DCs that were plasmacytoid (CD123+), with a decrease in the myeloid/plasmacytoid DC ratio. These changes were proportional to parasite loads but correlated neither with the intensity of clinical symptoms nor with circulating cytokine levels. One-third of P. vivax-infected patients, but no P. falciparum-infected subjects, showed impaired maturation of circulating DCs, with low surface expression of CD86. Although vivax malaria patients overall had a less inflammatory cytokine response, with a higher interleukin-10 (IL-10)/tumor necrosis factor alpha (TNF-α) ratio, this finding did not translate to milder clinical manifestations than those of falciparum malaria patients. We discuss the potential implications of these findings for species-specific pathogenesis and long-lasting protective immunity to malaria.

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