scholarly journals Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

2012 ◽  
Vol 4 (2) ◽  
pp. 88-96 ◽  
Author(s):  
Shuangtao Ma ◽  
Hao Yu ◽  
Zhigang Zhao ◽  
Zhidan Luo ◽  
Jing Chen ◽  
...  
Keyword(s):  
Trpm8 Channel ◽  
Cold Sensing

scholarly journals Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue

2017 ◽  
Vol 1864 (12) ◽  
pp. 2415-2427 ◽  
Author(s):  
Maria Nathália Moraes ◽  
Leonardo Vinicius Monteiro de Assis ◽  
Felipe dos Santos Henriques ◽  
Miguel Luiz Batista Jr ◽  
Ali D. Güler ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Trpm8 Channel ◽  
Circadian Control ◽  
Brown Adipose ◽  
Cold Sensing

scholarly journals Odontoblast TRPC5 channels signal cold pain in teeth

2021 ◽  
Vol 7 (13) ◽  
pp. eabf5567
Author(s):  
Laura Bernal ◽  
Pamela Sotelo-Hitschfeld ◽  
Christine König ◽  
Viktor Sinica ◽  
Amanda Wyatt ◽  
...  
Keyword(s):  
Relative Sensitivity ◽  
Cellular Component ◽  
Sensory Transduction ◽  
Cold Sensation ◽  
Cold Pain ◽  
Sensing System ◽  
Cold Sensitive ◽  
Cellular Components ◽  
Cold Sensor ◽  
Cold Sensing

Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensing system and show that sensory transduction of cold stimuli in teeth requires odontoblasts. TRPC5 is a cold sensor in healthy teeth and, with TRPA1, is sufficient for cold sensing. The odontoblast appears as the direct site of TRPC5 cold transduction and provides a mechanism for prolonged cold sensing via TRPC5’s relative sensitivity to intracellular calcium and lack of desensitization. Our data provide concrete functional evidence that equipping odontoblasts with the cold-sensor TRPC5 expands traditional odontoblast functions and renders it a previously unknown integral cellular component of the dental cold sensing system.

Cold sensing in grapevine-Which signals are upstream of the microtubular “thermometer”

2017 ◽  
Vol 40 (11) ◽  
pp. 2844-2857 ◽  
Author(s):  
Lixin Wang ◽  
Peter Nick
Keyword(s):  
Cold Sensing

Agonist of TRPM8 channel, menthol, facilitates the initiation of thermoregulatory responses to external cooling

2010 ◽  
Vol 35 (8) ◽  
pp. 428-434 ◽  
Author(s):  
T.V. Kozyreva ◽  
V.P. Kozaruk ◽  
E.Ya. Tkachenko ◽  
G.M. Khramova
Keyword(s):  
Trpm8 Channel ◽  
Thermoregulatory Responses ◽  
External Cooling

scholarly journals Regulation of Activity of Transient Receptor Potential Melastatin 8 (TRPM8) Channel by Its Short Isoforms

2011 ◽  
Vol 287 (5) ◽  
pp. 2948-2962 ◽  
Author(s):  
Gabriel Bidaux ◽  
Benjamin Beck ◽  
Alexander Zholos ◽  
Dmitri Gordienko ◽  
Loic Lemonnier ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Trpm8 Channel ◽  
Short Isoforms ◽  
Transient Receptor Potential Melastatin ◽  
Regulation Of Activity ◽  
Transient Receptor

scholarly journals TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells

Oncotarget ◽  
2015 ◽  
Vol 6 (19) ◽  
pp. 17221-17236 ◽  
Author(s):  
Swapna Asuthkar ◽  
Kiran Kumar Velpula ◽  
Pia A. Elustondo ◽  
Lusine Demirkhanyan ◽  
Eleonora Zakharian
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Molecular Target ◽  
Prostate Cancer Cells ◽  
Trpm8 Channel
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