scholarly journals Effects of the publication of Clinical Guidelines for the Management of Chemotherapy-Induced Peripheral Neuropathy on the Administration Preferences of Oncology Specialists: Japanese Association of Supportive Care in Cancer

2020 ◽  
Vol 50 (8) ◽  
pp. 897-902 ◽  
Author(s):  
Yasuo Hirayama ◽  
Yoichiro Yoshida ◽  
Masanori Mori ◽  
Kazuo Tamura
Keyword(s):  
Peripheral Neuropathy ◽  
Supportive Care ◽  
Clinical Guidelines ◽  
Questionnaire Survey ◽  
Japanese Society ◽  
Medical Oncology ◽  
Prescription Rate ◽  
Point Scale ◽  
Antiepileptic Agents ◽  
Inflammatory Drugs

Abstract Objective We conducted a questionnaire survey of oncology specialists to investigate the frequency of administration of different drugs for the management of chemotherapy-induced peripheral neuropathy in Japan in 2015. Our group published Clinical Guidelines for the Management of Chemotherapy-Induced Peripheral Neuropathy in 2017 (CIPN-GL2017). In these guidelines, we recommended duloxetine only. To verify the effect of the publication of the CIPN-GL2017, we conducted a questionnaire survey in 2019. Methods In 2015 and again in 2019, we investigated the use of vitamin B12, antiepileptic agents, duloxetine, antidepressants other than duloxetine, non-steroidal anti-inflammatory drugs, opioids and the Kampo compound (goshajinkigan) in a questionnaire employing a three-point scale wherein A implies routine or prophylactic administration, B implies occasional administration and C implies infrequent administration. Results We sent the questionnaires via email to 971 diplomates of the Subspecialty Board of Japanese Society of Medical Oncology in 2015 and 1239 diplomates in 2019. The administration ratio (A + B) of duloxetine for numbness and pain was 46.8 and 31.7%, respectively, in 2015 and 68.9% (P < 0.01) and 73.1% (P < 0.01) in 2019. In response to the question regarding awareness of the CIPN-GL2017, 53.2% of respondents to the 2019 questionnaire were aware of the CIPN-GL2017. Among the respondents with an awareness of the CIPN-GL2017, the prescription rate of duloxetine (78.3%) for pain was significantly higher than that among respondents without any awareness (67.4%). Conclusions It is possible that the publication of CIPN-GL2017 influenced administration preferences of oncology specialists.

scholarly journals Survey of the management of chemotherapy-induced peripheral neuropathy in Japan: Japanese Society of Medical Oncology

ESMO Open ◽  
2016 ◽  
Vol 1 (3) ◽  
pp. e000053 ◽  
Author(s):  
Yasuo Hirayama ◽  
Jiichiro Sasaki ◽  
Hirotoshi Dosaka-Akita ◽  
Kunihiko Ishitani
Keyword(s):  
Peripheral Neuropathy ◽  
Japanese Society ◽  
Medical Oncology

scholarly journals Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, 4th edition

2020 ◽  
Vol 111 (10) ◽  
pp. 3962-3969 ◽  
Author(s):  
Hiromichi Ebi ◽  
Hideaki Bando ◽  
Hiroya Taniguchi ◽  
Yu Sunakawa ◽  
Yoshinaga Okugawa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Treatment ◽  
Clinical Guidelines ◽  
Japanese Society ◽  
Medical Oncology ◽  
Molecular Testing ◽  
Colorectal Cancer Treatment

scholarly journals Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition

2018 ◽  
Vol 109 (6) ◽  
pp. 2074-2079 ◽  
Author(s):  
Kentaro Yamazaki ◽  
Hiroya Taniguchi ◽  
Takayuki Yoshino ◽  
Kiwamu Akagi ◽  
Hideyuki Ishida ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Treatment ◽  
Clinical Guidelines ◽  
Japanese Society ◽  
Medical Oncology ◽  
Molecular Testing ◽  
Colorectal Cancer Treatment

scholarly journals Establishment of a research policy for supportive and palliative care in Japan

2021 ◽  
Author(s):  
Sadamoto Zenda ◽  
Yosuke Uchitomi ◽  
Tatsuya Morita ◽  
Takuhiro Yamaguchi ◽  
Akira Inoue
Keyword(s):  
Palliative Care ◽  
Supportive Care ◽  
Clinical Research ◽  
Japanese Society ◽  
Medical Oncology ◽  
Research Policy ◽  
Psychosocial Care ◽  
Target Population ◽  
Exploratory Research ◽  
New Research

Abstract Background While several small groups in Japan have attempted to conduct prospective studies in the field of supportive and palliative care, development of exploratory research into multicentre confirmatory studies has been difficult. The main reason for this is the difference in clinical research methodology in supportive and palliative care compared with medical oncology in terms of the style of multidisciplinary approaches, study design and endpoints. Here, we establish a new research policy for cancer supportive and palliative care in Japan. Methods The first draft was developed by a policy working group within the Japanese Supportive, Palliative and Psychosocial Care Study Group. A provisional draft was subsequently developed after review by nine Japanese scientific societies (Japanese Association of Supportive Care in Cancer, Japanese Society of Medical Oncology, Japanese Society of Clinical Oncology, Japanese Society of Palliative Medicine, Japanese Society of Cancer Nursing, Japanese Society of Pharmaceutical Oncology (JASPO), Japan Cancer Association (JCA), Japanese Society of Therapeutic Radiation Oncology and Japanese Cancer Association) and receipt of public comments. The final research policy in the area of supportive and palliative care in Japan (Ver1.0) was completed in December 2018 and underwent its first revision (Ver1.1) in February, 2020. Results The policy includes the following components of clinical research: (i) objective of the research policy in the areas of supportive and palliative care; (ii) definitions of supportive care and palliative care; (iii) characteristics of supportive and palliative care research; (iv) target population for research; (v) research design; (vi) endpoints and assessment measures; (vii) handling of the deaths of subjects and (viii) operational structure and quality management. Conclusions We hope that studies conducted according to this policy will play important roles in the future development of the supportive and palliative field.

scholarly journals Dental implant care and trouble among dependent patients based on the questionnaire survey among Japanese dental practitioners

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuji Sato ◽  
Shigeto Koyama ◽  
Chikahiro Ohkubo ◽  
Shin Ogura ◽  
Ryutaro Kamijo ◽  
...  
Keyword(s):  
Elderly People ◽  
Dental Care ◽  
Questionnaire Survey ◽  
Japanese Society ◽  
Dental Treatment ◽  
Actual State ◽  
Treatment Type ◽  
Dental Practitioners ◽  
Care Problems ◽  
Implant Treatment

Abstract Background Self-care and professional care of implants may prove difficult for elderly people who require nursing care. However, the actual state of care and problems remains unknown. In this study, we investigated the actual state of implant problems in elderly people living in their own home or in a nursing home who received visiting dental treatment. Methods We mailed questionnaire survey forms to 2339 representatives or specialists who were members of the Japanese Society of Oral Implantology, the Japanese Society of Gerodontology or the Japan Prosthodontic Society. We narrowed down the respondents to those who provided visiting dental treatment, and analyzed the actual state of implants observed during visiting dental treatment (type, care, problems, countermeasures, etc.). Results Of the 924 dentists who responded to the questionnaire survey, 291 (22%) provided visiting dental treatment. While the majority of implant types encountered in the previous 12 months were root-form implants, there were still a certain number of blade and subperiosteal implants. Daily implant care involved mostly cleaning with a toothbrush + auxiliary tools. The most frequent implant problems encountered in the past were difficulty in cleaning and peri-implantitis. Medication and antiphlogistic treatment were most frequently adopted as countermeasures to implant problems, followed by observation. When we classified the results into those for the dentists who provided implant treatment and those for the dentists who did not, we found that many of the dentists who did not provide implant treatment opted for observation or medication, while those who provided implant treatment also implemented removal of superstructure, retightening of screws, repair and so forth. Conclusions We found that many of the implant troubles encountered by dentists who provided visiting dental care were difficulty in cleaning or peri-implantitis, and that the actions taken against these troubles varied depending on the experience of the dentist performing the implant treatment. Our study also revealed that dentists who provide visiting dental care need to acquire knowledge and skills of implant treatment, to have actions prepared in case they encounter such cases, or to closely coordinate with dentists who specialize in implants.

Pain pharmacogenetics

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Mariia A. Slepukhina ◽  
Dmitriy V. Ivashchenko ◽  
Maria A. Sheina ◽  
Andranik Alexandrovich Muradian ◽  
Dmitriy Alexeevich Blagovestnov ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Body ◽  
Postoperative Analgesia ◽  
Clinical Guidelines ◽  
Original Research ◽  
General Anesthetics ◽  
Main Subject ◽  
Current Review ◽  
Inflammatory Drugs ◽  
Selection Of

AbstractPain is a significant problem in medicine. The use of PGx markers to personalize postoperative analgesia can increase its effectiveness and avoid undesirable reactions. This article describes the mechanisms of nociception and antinociception and shows the pathophysiological mechanisms of pain in the human body. The main subject of this article is pharmacogenetic approach to the selection of anesthetics. Current review presents data for local and general anesthetics, opioids, and non-steroidal anti-inflammatory drugs. None of the anesthetics currently has clinical guidelines for pharmacogenetic testing. This literature review summarizes the results of original research available, to date, and draws attention to this area.

scholarly journals A questionnaire survey on evaluation for penetration and compliance of the Japanese Guideline on Febrile Neutropenia among hematology-oncology physicians and surgeons

2021 ◽  
Author(s):  
Nobu Akiyama ◽  
Takuho Okamura ◽  
Minoru Yoshida ◽  
Shun-ichi Kimura ◽  
Shingo Yano ◽  
...  
Keyword(s):  
High Risk ◽  
Febrile Neutropenia ◽  
Supportive Care ◽  
Questionnaire Survey ◽  
Primary Treatment ◽  
Beta Lactam ◽  
Clinical Practices ◽  
High Risk Patients ◽  
Mascc Score ◽  
Risk Patients

Abstract Purpose The Japanese Society of Medical Oncology published a guideline (GL) on febrile neutropenia (FN) in 2017. The study’s purpose is to reveal how widely GL penetrated among physicians and surgeons providing chemotherapy. Methods A questionnaire survey was conducted with SurveyMonkey™ for members of the Japanese Association of Supportive Care in Cancer and relevant academic organizations. Each question had four options (always do, do in more than half of patients, do in less than half, do not at all) and a free description form. Responses were analyzed with statistical text-analytics. Result A total of 800 responses were retrieved. Major respondents were experts with more than 10-year experience, physicians 54%, and surgeons 46%. Eighty-seven percent of respondents knew and used GL. Forty-eight percent assessed FN with Multinational Association of Supportive Care in Cancer (MASCC) score “always” or “more than half.” Eighty-one percent chose beta-lactam monotherapy as primary treatment in high-risk patients. Seventy-seven percent did oral antibacterial therapy in low-risk patients ambulatorily. Seventy-eight percent administered primary prophylactic G-CSF (ppG-CSF) in FN frequency ≥ 20% regimen. Fifty-nine percent did ppG-CSF for high-risk patients in FN frequency 10–20% regimen. Ninety-seven percent did not use ppG-CSF in FN frequency < 10% regimen. The medians of complete and complete plus partial compliance rates were 46.4% (range 7.0–92.8) and 77.8% (range 35.4–98.7). The complete compliance rates were less than 30% in seven recommendations, including the MASCC score assessment. Conclusion GL is estimated to be widely utilized, but some recommendations were not followed, presumably due to a mismatch with actual clinical practices in Japan.

scholarly journals ESMO Open welcomes the association with the Japanese Society of Medical Oncology (JSMO)

ESMO Open ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. e000240
Author(s):  
Yuichiro Ohe ◽  
Christoph Zielinski
Keyword(s):  
Japanese Society ◽  
Medical Oncology

scholarly journals Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians

2018 ◽  
Vol 32 (3) ◽  
pp. 463-478 ◽  
Author(s):  
Masahiko Sumitani ◽  
Tetsuya Sakai ◽  
Yoichi Matsuda ◽  
Hiroaki Abe ◽  
Shigeki Yamaguchi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Clinical Guidelines ◽  
Japanese Society ◽  
Executive Summary
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