Characterization of Class I– and Class II–Like Major Histocompatibility Complex Loci in Pedigrees of North Atlantic Right Whales

2013 ◽  
Vol 105 (2) ◽  
pp. 188-202 ◽  
Author(s):  
Roxanne M. Gillett ◽  
Brent W. Murray ◽  
Bradley N. White
Keyword(s):  
Major Histocompatibility Complex ◽  
North Atlantic ◽  
Class Ii ◽  
Class I ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Right Whales ◽  
North Atlantic Right Whales

Characterization of major histocompatibility complex class I, and class II DRB loci of captive and wild Indian leopards (Panthera pardus fusca)

Genetica ◽  
2017 ◽  
Vol 145 (6) ◽  
pp. 541-558
Author(s):  
Drashti R. Parmar ◽  
Siuli Mitra ◽  
Snehalata Bhadouriya ◽  
Tirupathi Rao ◽  
Vaishnavi Kunteepuram ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class Ii ◽  
Class I ◽  
Panthera Pardus ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I AND CLASS II EXPRESSION BY MYOCYTES IN CARDIAC BIOPSIES POSTTRANSPLANTATION

1988 ◽  
Vol 45 (5) ◽  
pp. 972-978 ◽  
Author(s):  
A. AHMED-ANSARI ◽  
TALAAT S. TADROS ◽  
WILLIAM D. KNOPF ◽  
DOUGLAS A. MURPHY ◽  
GARY HERTZLER ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class Ii ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 ◽  
Vol 174 (6) ◽  
pp. 1607-1615 ◽  
Author(s):  
E Mellins ◽  
S Kempin ◽  
L Smith ◽  
T Monji ◽  
D Pious
Keyword(s):  
Major Histocompatibility Complex ◽  
Antigen Presentation ◽  
Somatic Cell ◽  
Class Ii ◽  
Homozygous Deletion ◽  
Class I ◽  
Somatic Cell Hybrids ◽  
Major Histocompatibility ◽  
Cell Hybrids ◽  
Histocompatibility Complex

We have previously described a set of mutants (16.23-selected mutants) of a B lymphoblastoid cell line that are defective in the presentation of intact proteins to class II-restricted T cells, but effectively present immunogenic peptides. The mutations in these mutants are recessive in somatic cell hybrids and are not in Class II structural genes. Here, we report on a unique mutant, 5.2.4, in which a similar defect in class II-restricted antigen presentation has occurred in association with a one-megabase homozygous deletion in the class II region of the major histocompatibility complex (MHC). The defects in class II presentation among three of the 16.23-selected mutants, and between these mutants and 5.2.4, are noncomplementary in somatic cell hybrids. This suggests that the class II presentation-defective phenotype in all four mutants results from lesions in a single MHC-linked gene, a conclusion strengthened by the finding that in a hybrid made with a second, unrelated MHC deletion mutant, T2, the class II presentation defect in a 16.23-selected mutant is also not complemented. Mutant 5.2.4, in addition to its class II presentation defect, is also defective in surface expression of MHC class I molecules, most likely because its deletion encompasses the peptide supply factor 1 gene, whose function is known to be required for normal abundance of cell surface class I molecules. However, the surface abundance of class I molecules is normal in the 16.23-selected mutants, suggesting that the lesions affecting class I surface abundance and class II presentation result from mutations in different genes.

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