scholarly journals A Nucleotide Substitution Responsible for the Tawny Coat Color Mutation Carried by the MSKR Inbred Strain of Mice

2005 ◽  
Vol 96 (2) ◽  
pp. 145-149 ◽  
Author(s):  
A. Wada ◽  
T. Kunieda ◽  
M. Nishimura ◽  
Y. Kakizoe-Ishida ◽  
N. Watanabe ◽  
...  
1991 ◽  
Vol 40 (3) ◽  
pp. 375-379
Author(s):  
Katsuhiro FUKUTA ◽  
Kenkichi IMAMURA ◽  
Nobuo GOTO

1980 ◽  
Vol 71 (1) ◽  
pp. 49-51 ◽  
Author(s):  
B. ELIZABETH HORNER ◽  
GARY L. POTTER ◽  
SUELLEN VAN OOTEGHEM

1975 ◽  
Vol 66 (4) ◽  
pp. 246-247 ◽  
Author(s):  
J. S. PETERSON ◽  
C. H. YOON

1998 ◽  
Vol 275 (1) ◽  
pp. R29-R32 ◽  
Author(s):  
Gary E. Truett ◽  
Robert J. Tempelman ◽  
Jerilyn A. Walker ◽  
J. Krause Wilson

The misty ( m) coat color mutation is commonly maintained in linkage disequilibrium with the obesity mutation diabetes ( Leprdb ) to serve as a marker for Leprdb genotype. Comparisons among Leprdb genotypes are made under the untested assumption that m has no effects on traits under investigation. We tested this assumption in a population segregating m in the absence of db. Analysis of growth curves revealed that m/m mice are smaller than M/M mice by the 2nd wk of life and remain smaller through the 5th wk of life. Analysis of variance of three traits measured at 35 days of age revealed that m/m mice are 8% shorter than M/M mice, weigh 15% less, and have 21% less inguinal adipose mass. These results indicate that m affects growth traits. Therefore, when m and Leprdb segregate in the same cross, interpretation of their effects is confounded by linkage. More accurate estimates of Leprdb genotype effects can be made by removing m from populations segregating Leprdb and using a direct assay to measure Leprdb genotype.


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