Chlordimeform and Related Compounds: Toxicological Studies with House Flies12

1973 ◽  
Vol 66 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Charles O. Knowles ◽  
Surendra P. Shrivastava
Keyword(s):  
Toxicological Studies ◽  
Related Compounds

PREPARATION AND TOXICITY OF SOME ALKYL THIOPYROPHOSPHATES

1956 ◽  
Vol 34 (12) ◽  
pp. 1819-1832 ◽  
Author(s):  
R. A. McIvor ◽  
G. D. McCarthy ◽  
G. A. Grant
Keyword(s):  
High Yield ◽  
Inorganic Salts ◽  
Infrared Study ◽  
Toxicological Studies ◽  
Related Compounds

Several methods have been investigated for the synthesis of tetraalkyl thiopyrophosphates, including one that can be carried out very rapidly with high yield. Purification of these compounds proved exceedingly difficult, because they were sensitive to traces of acids or bases, and probably to inorganic salts at temperatures above 70 °C. All methods investigated yield only the thiono isomer, there being no evidence for the corresponding P—S—P isomer. Toxicological studies do not support the results reported by Fiszer and workers. None of the compounds is more toxic intravenously than tetraethyl pyrophosphate. The synthesis of several other related compounds for infrared study is reported.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Zebrafish models for hallucinogenic-related compounds

2013 ◽  
Author(s):  
A. V. Kalueff ◽  
A. M. Stewart ◽  
V. Gjeloshi ◽  
D. Kondaveeti ◽  
N. Neelkantan ◽  
...  
Keyword(s):  
Related Compounds

Taxonomic distribution of thymoquinone and related compounds in selected plant species

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Táborský ◽  
M Kunt ◽  
P Kloucek ◽  
L Kokoska
Keyword(s):  
Plant Species ◽  
Taxonomic Distribution ◽  
Related Compounds

Toxicological studies on the Eugenia dysenterica DC and Caryocar brasiliense Cambess leaves in rats

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
F Elias ◽  
T Zils ◽  
FGL Aguiar ◽  
ELE Barros ◽  
ME Molica ◽  
...  
Keyword(s):  
Toxicological Studies ◽  
Caryocar Brasiliense ◽  
Eugenia Dysenterica ◽  
Caryocar Brasiliense Cambess

Analysis of stably expressed genes with low-dose etoposide for toxicological studies in osteosarcoma

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
JMP Ferreira de Oliveira ◽  
L Almeida ◽  
F Pimentel ◽  
EJJ Van Zoelen ◽  
C Santos
Keyword(s):  
Low Dose ◽  
Toxicological Studies
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