Ionizing Irradiation of Adults of Angoumois Grain Moth (Lepidoptera: Gelechiidae) and Indianmeal Moth (Lepidoptera: Pyralidae) to Prevent Reproduction, and Implications for a Generic Irradiation Treatment for Insects

2008 ◽  
Vol 101 (4) ◽  
pp. 1051-1056 ◽  
Author(s):  
Guy J. Hallman ◽  
Thomas W. Phillips
Keyword(s):  
Ionizing Irradiation ◽  
Indianmeal Moth ◽  
Angoumois Grain Moth ◽  
Irradiation Treatment ◽  
Lepidoptera Pyralidae

Cry 1Ab and Cry 9C Transgenic Corn Hybrid Effects on Laboratory Populations of Indianmeal Moth (Lepidoptera: Pyralidae) and Angoumois Grain Moth (Lepidoptera: Gelechiidae)

2004 ◽  
Vol 39 (4) ◽  
pp. 514-524 ◽  
Author(s):  
Anthony M. Hanley ◽  
Tonja M. Wilkins ◽  
John D. Sedlacek
Keyword(s):  
Bt Corn ◽  
35S Promoter ◽  
Corn Hybrids ◽  
Indianmeal Moth ◽  
Angoumois Grain Moth ◽  
Laboratory Populations ◽  
Lepidoptera Pyralidae ◽  
The Impact ◽  
Grain Bins ◽  
Cry 1Ab

Several Bacillus thuringiensis Berliner (Bt) Cry proteins including Cry 1Ab, Cry 1Ac, and Cry 9C, have been observed at relatively high levels in Bt corn grain using the CaMV 35S promoter. Thus, a laboratory experiment was conducted to quantify the impact of DeKalb 679 BTY Cry 1 Ab (MON 810) and Garst 8600 BLT Cry 9C (CBH 351) transgenic grain on Indianmeal moth, Plodia interpunctella (Hübner), and Angoumois grain moth, Sitotroga cerealella (Olivier), survival, development and fecundity. Eggs of Indianmeal moth or Angoumois grain moth were added to cracked or whole kernel corn. Emergence and fecundity were recorded for 5 wks. Emergence and fecundity of both moth species was reduced on both Cry 1Ab and Cry 9C-transformed corn, but only Cry 1 Ab-transformed corn delayed development of Indianmeal moth. Results indicate that populations of these moths may be negatively impacted in grain bins by Bt corn hybrids and that lepidopteran populations should be monitored in field-scale assays to examine the effects of the presence of Bt corn hybrids on insects in storage environments.

Carnosine increases efficiency of temozolomide and irradiation treatment of isocitrate dehydrogenase-wildtype glioblastoma cells in culture

2019 ◽  
Vol 15 (32) ◽  
pp. 3683-3691
Author(s):  
Johannes Dietterle ◽  
Henry Oppermann ◽  
Annegret Glasow ◽  
Karsten Neumann ◽  
Jürgen Meixensberger ◽  
...  
Keyword(s):  
Side Effects ◽  
Cell Cultures ◽  
Isocitrate Dehydrogenase ◽  
Standard Therapy ◽  
Primary Cell ◽  
Ionizing Irradiation ◽  
Cells In Culture ◽  
Naturally Occurring ◽  
Irradiation Treatment ◽  
Different Doses

Aim: The naturally occurring dipeptide carnosine (CAR) has been considered for glioblastoma therapy. As CAR also protects against ionizing irradiation (IR), we investigated whether it may counteract standard therapy consisting of postsurgery IR and treatment with temozolomide (TMZ). Materials & methods: Four isocitrate dehydrogenase-wildtype primary cell cultures were exposed to different doses of IR and different concentrations of TMZ and CAR. After exposure, viability under the different conditions and combinations of them was determined. Results: All cultures responded to treatment with TMZ and IR with reduced viability. CAR further decreased viability when TMZ and IR were combined. Conclusion: Treatment with CAR does not counteract glioblastoma standard therapy. As the dipeptide also protects nontumor cells from IR, it may reduce deleterious side effects of treatment.

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