In situ screening for postsynaptic cell adhesion molecules during synapse formation

2017 ◽  
Author(s):  
Takeshi Uemura ◽  
Tomoko Shiroshima ◽  
Asami Maeda ◽  
Misato Yasumura ◽  
Takashi Shimada ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Synapse Formation ◽  
Postsynaptic Cell

In Situ Expression of Cell Adhesion Molecules in Chronic Gastritis with Helicobacter pylori Infection

1997 ◽  
Vol 25 ◽  
pp. S215-S221 ◽  
Author(s):  
Kazuhide Higuchi ◽  
Tetsuo Arakawa ◽  
Toshiyuki Uchida ◽  
Koichiro Nakagawa ◽  
Shiro Nakamura ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Chronic Gastritis ◽  
Cell Adhesion Molecules ◽  
Helicobacter Pylori Infection

scholarly journals Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

2009 ◽  
Vol 28 (22) ◽  
pp. 3564-3578 ◽  
Author(s):  
So-Hee Lim ◽  
Seok-Kyu Kwon ◽  
Myung Kyu Lee ◽  
Jeonghee Moon ◽  
Dae Gwin Jeong ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Protein Tyrosine Phosphatase ◽  
Cell Adhesion Molecules ◽  
Synapse Formation ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine

scholarly journals The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function

2009 ◽  
Vol 14 (1) ◽  
Author(s):  
Michael Hortsch ◽  
Kakanahalli Nagaraj ◽  
Tanja Godenschwege
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Neural Differentiation ◽  
Synapse Formation ◽  
Axonal Outgrowth ◽  
Axonal Pathfinding ◽  
Independent Functions ◽  
Adhesive Proteins ◽  
Axon Initial Segments

AbstractL1-type cell adhesion molecules (CAMs) are important mediators of neural differentiation, including axonal outgrowth and pathfinding and also of synapse formation and maintenance. In addition, their interactions with cytoskeletal components are highly conserved and regulated. How these different aspects of CAM functionality relate to each other is not well understood. Based on results from our and other laboratories we propose that ankyrin-binding to L1-type CAMs provides a master switch. The interaction with ankyrins directs L1-type adhesive proteins into different functional contexts, either ankyrin-independent functions, such as neurite outgrowth and axonal pathfinding or into ankyrin-dependent functions, such as L1’s role at axon initial segments (AIS), paranodal regions, synapses and in dendrites.

scholarly journals MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development

2014 ◽  
Vol 369 (1652) ◽  
pp. 20130517 ◽  
Author(s):  
Cecilia S. Lu ◽  
Bo Zhai ◽  
Alex Mauss ◽  
Matthias Landgraf ◽  
Stephen Gygi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Synapse Formation ◽  
Neuromuscular Junctions ◽  
Neuromuscular Synapse ◽  
Fine Tuning ◽  
Synapse Development ◽  
Stable Isotope Labelling ◽  
Coordinate Regulation

Neuronal connectivity and specificity rely upon precise coordinated deployment of multiple cell-surface and secreted molecules. MicroRNAs have tremendous potential for shaping neural circuitry by fine-tuning the spatio-temporal expression of key synaptic effector molecules. The highly conserved microRNA miR-8 is required during late stages of neuromuscular synapse development in Drosophila . However, its role in initial synapse formation was previously unknown. Detailed analysis of synaptogenesis in this system now reveals that miR-8 is required at the earliest stages of muscle target contact by RP3 motor axons. We find that the localization of multiple synaptic cell adhesion molecules (CAMs) is dependent on the expression of miR-8, suggesting that miR-8 regulates the initial assembly of synaptic sites. Using stable isotope labelling in vivo and comparative mass spectrometry, we find that miR-8 is required for normal expression of multiple proteins, including the CAMs Fasciclin III (FasIII) and Neuroglian (Nrg). Genetic analysis suggests that Nrg and FasIII collaborate downstream of miR-8 to promote accurate target recognition. Unlike the function of miR-8 at mature larval neuromuscular junctions, at the embryonic stage we find that miR-8 controls key effectors on both sides of the synapse. MiR-8 controls multiple stages of synapse formation through the coordinate regulation of both pre- and postsynaptic cell adhesion proteins.

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