scholarly journals Transcriptional and Post-transcriptional Regulation in TGF- -mediated epithelial-mesenchymal transition

2012 ◽  
Vol 151 (6) ◽  
pp. 563-571 ◽  
Author(s):  
M. Saitoh ◽  
K. Miyazawa
Keyword(s):  
Transcriptional Regulation ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Post Transcriptional Regulation

scholarly journals Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status

Cell Cycle ◽  
2010 ◽  
Vol 9 (18) ◽  
pp. 3831-3838 ◽  
Author(s):  
Alejandro Vazquez-Martin ◽  
Cristina Oliveras-Ferraros ◽  
Sílvia Cufí ◽  
Sonia Del Barco ◽  
Begoña Martin-Castillo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition

scholarly journals MicroRNAs regulate the epithelial–mesenchymal transition and influence breast cancer invasion and metastasis

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769168 ◽  
Author(s):  
Min Zhao ◽  
Lin Ang ◽  
Jin Huang ◽  
Jin Wang
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
Mesenchymal Phenotype ◽  
Mesenchymal Transition ◽  
Rna Molecules ◽  
Breast Cancer Invasion ◽  
Proliferation And Apoptosis ◽  
Post Transcriptional Regulation

MicroRNAs are small RNA molecules that play a major role in the post-transcriptional regulation of genes and influence the development, differentiation, proliferation, and apoptosis of cells and the development and progression of tumors. The epithelial–mesenchymal transition is a process by which epithelial cells morphologically transform into cells with a mesenchymal phenotype. The epithelial–mesenchymal transition plays a highly important role in tumor invasion and metastasis. Increasing evidence indicates that microRNAs are tightly associated with epithelial–mesenchymal transition regulation in tumor cells. In breast cancer, various microRNA molecules have been identified as epithelial–mesenchymal transition inducers or inhibitors, which, through different mechanisms and signaling pathways, participate in the regulation of breast cancer invasion and metastasis among various biological behaviors. The epithelial–mesenchymal transition–related microRNAs in breast cancer provide valuable molecules for researching cell invasion and metastasis, and they also provide candidate targets that may be significant for the targeted therapy of breast cancer.

MicroRNA-Mediated Post-Transcriptional Regulation of Epithelial to Mesenchymal Transition in Cancer

2016 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Golnoush Dehbashi Behbahani ◽  
Nastaran Mohammadi Ghahhari ◽  
Mohammad Amin Javidi ◽  
Asghar Farzi Molan ◽  
Neda Feizi ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Post Transcriptional Regulation

scholarly journals Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1178 ◽  
Author(s):  
Jun-Ting Cheng ◽  
Lingzhi Wang ◽  
Hong Wang ◽  
Feng-Ru Tang ◽  
Wen-Qi Cai ◽  
...  
Keyword(s):  
Target Genes ◽  
Epithelial Mesenchymal Transition ◽  
Therapeutic Potential ◽  
Cell Types ◽  
Mesenchymal Transition ◽  
Cellular Processes ◽  
Epithelial Plasticity ◽  
Post Transcriptional Regulation ◽  
Emt Markers

Long non-coding RNAs (lncRNAs) are versatile regulators of gene expression and play crucial roles in diverse biological processes. Epithelial-mesenchymal transition (EMT) is a cellular program that drives plasticity during embryogenesis, wound healing, and malignant progression. Increasing evidence shows that lncRNAs orchestrate multiple cellular processes by modulating EMT in diverse cell types. Dysregulated lncRNAs that can impact epithelial plasticity by affecting different EMT markers and target genes have been identified. However, our understanding of the landscape of lncRNAs important in EMT is far from complete. Here, we summarize recent findings on the mechanisms and roles of lncRNAs in EMT and elaborate on how lncRNAs can modulate EMT by interacting with RNA, DNA, or proteins in epigenetic, transcriptional, and post-transcriptional regulation. This review also highlights significant EMT pathways that may be altered by diverse lncRNAs, thereby suggesting their therapeutic potential.

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