Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells

2011 ◽  
Vol 150 (4) ◽  
pp. 461-471 ◽  
Author(s):  
M. Horie ◽  
K. Nishio ◽  
H. Kato ◽  
K. Fujita ◽  
S. Endoh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intracellular Calcium ◽  
Cerium Oxide ◽  
Calcium Level ◽  
Cellular Responses ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Culture Cells ◽  
Intracellular Calcium Level ◽  
And Oxidative Stress

scholarly journals Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties

ACS Nano ◽  
2008 ◽  
Vol 2 (10) ◽  
pp. 2121-2134 ◽  
Author(s):  
Tian Xia ◽  
Michael Kovochich ◽  
Monty Liong ◽  
Lutz Mädler ◽  
Benjamin Gilbert ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mechanism Of Toxicity ◽  
And Oxidative Stress

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

Cerium oxide nanoparticles protects against acrylamide induced toxicity in HepG2 cells through modulation of oxidative stress

2018 ◽  
Vol 42 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Aala Azari ◽  
Mohammad Shokrzadeh ◽  
Ehsan Zamani ◽  
Nahid Amani ◽  
Fatemeh Shaki
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Hepg2 Cells ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Cerium oxide nanoparticles and their importance in cell signaling pathways for predicting cellular behavior

Nanomedicine ◽  
2020 ◽  
Vol 15 (17) ◽  
pp. 1709-1718
Author(s):  
Atefeh Pesaraklou ◽  
Maryam M Matin
Keyword(s):  
Signaling Pathways ◽  
Cerium Oxide ◽  
Cellular Responses ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Signaling Proteins ◽  
Cellular Behavior ◽  
Anti Oxidant ◽  
Different Response ◽  
Cell Signaling Pathways

Cerium oxide nanoparticles (CeO2-NPs) have prolifically attracted immense interest of researchers due to their prominent anti-oxidant nature. However, these characteristics are accompanied by some ambiguities in other studies reporting their oxidant and toxic properties. In this regard previous literature has pointed to the importance of the NPs morphology and environmental conditions as well as biomolecules that induce a different response by initiating a cascade of activities. Therefore, due to the fact that signaling proteins are key mediators in cellular responses, the cognizance of the CeO2-NP-targeted signaling pathways could facilitate predicting the cellular behavior and thus more efficient applications of these NPs for clinical purposes. Consequently, a comprehensive review is necessary in this field, to clarify the impacts of CeO2-NPs on various signaling pathways.

scholarly journals Cerium oxide nanoparticles induce oxidative stress in the sediment-dwelling amphipodCorophium volutator

2015 ◽  
Vol 10 (4) ◽  
pp. 480-487 ◽  
Author(s):  
Yuktee Dogra ◽  
Kenton P. Arkill ◽  
Christine Elgy ◽  
Bjorn Stolpe ◽  
Jamie Lead ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats’ Kidney, Lung, and Serum

2020 ◽  
Vol 24 (4) ◽  
pp. 251-256
Author(s):  
Adel Sepanjnia ◽  
Hassan Ghasemi ◽  
Roohollah Mohseni ◽  
Akram Ranjbar ◽  
Fatemeh Shabani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers
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