Analysis of Inhibition Rate Enhancement by Covalent Linkage of Antithrombin to Heparin as a Potential Predictor of Reaction Mechanism

2006 ◽  
Vol 141 (1) ◽  
pp. 25-35 ◽  
Author(s):  
S. Patel ◽  
L. R. Berry ◽  
A. K.C. Chan
Keyword(s):  
Reaction Mechanism ◽  
Inhibition Rate ◽  
Covalent Linkage ◽  
Rate Enhancement ◽  
Potential Predictor

scholarly journals Unexpected polymerization mechanism of dilignol in the lignin growing

2019 ◽  
Vol 6 (7) ◽  
pp. 190445 ◽  
Author(s):  
Yasuyuki Matsushita ◽  
Yuto Oyabu ◽  
Dan Aoki ◽  
Kazuhiko Fukushima
Keyword(s):  
Reaction Mechanism ◽  
Higher Plants ◽  
Phenoxy Radical ◽  
Covalent Linkage ◽  
Polymerization Mechanism ◽  
Essential Component ◽  
Radical Coupling ◽  
Unexpected Reaction ◽  
Lignin Polymerization ◽  
Dehydrogenative Polymerization

Lignin is an essential component of higher plants, which is built by the enzymatic dehydrogenative polymerization of monolignols. First, monolignol is enzymatically oxidized to produce the phenoxy radical, which can form resonance hybrids. Two radical resonant hybrids are coupled with each other to yield dilignol with various linkage types, of which the main structures are β- O -4′ ( I ), β-5′ ( II ) and β-β′ ( III ). However, the reaction mechanism behind the addition lignol radicals to dilignol is not yet fully understood. Here, we show an unexpected reaction with structure II during enzymatic dehydrogenative polymerization, which involves cleavage of a covalent linkage and creation of a new radical coupling site. This implied that the β-5 dilignol diversifies the growing pattern of lignin. This discovery elucidates a novel mechanism in lignin polymerization.

Arylation of enelactams using TIPSOTf: reaction scope and mechanistic insight

2021 ◽  
Author(s):  
Tomasz J. Idzik ◽  
Zofia M. Myk ◽  
Łukasz Struk ◽  
Magdalena Perużyńska ◽  
Gabriela Maciejewska ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Multinuclear Nmr ◽  
Mechanistic Insight ◽  
Nmr Study ◽  
Wide Range

Triisopropylsilyltrifluoromethanesulfonate can be effectively used for the arylation of a wide range of enelactams. The multinuclear NMR study provided deep insights into the reaction mechanism.

Cocaine-Induced Locomotion as a Potential Predictor of Impulsivity in Rats

2007 ◽  
Author(s):  
Ashley E. Light ◽  
Lauren Sehy ◽  
Joshua M. Gulley
Keyword(s):  
Potential Predictor

Theoretical study of the ketonization reaction mechanism of acetic acid over SiO2

2009 ◽  
Author(s):  
Mendel Fleisher ◽  
E. Lukevics ◽  
L. Leite ◽  
D. Jansone ◽  
K. Edolfa ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Reaction Mechanism ◽  
Theoretical Study

OPTIMIZATION OF A SURROGATE REDUCED AVIATION FUEL-AIR REACTION MECHANISM USING A GENETIC ALGORITHM

Clean Air ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 1-24
Author(s):  
M. Pourkashanian ◽  
N. S. Mera ◽  
Lionel Elliott ◽  
C. W. Wilson ◽  
Derek B. Ingham ◽  
...  
Keyword(s):  
Genetic Algorithm ◽  
Reaction Mechanism ◽  
Aviation Fuel

Ligand-Enabled γ-C(sp3)–H Olefination of Free Carboxylic Acids

2020 ◽  
Author(s):  
Kiron Kumar Ghosh ◽  
Alexander Uttry ◽  
Francesca Ghiringhelli ◽  
Arup Mondal ◽  
Manuel van Gemmeren
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Michael Addition ◽  
Kinetic Studies ◽  
Wide Range ◽  
Palladium Catalyzed

We report the ligand enabled C(sp3)–H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael-addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.<br>

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