scholarly journals Emergence of clonal fluconazole-resistant Candida parapsilosis clinical isolates in a multicentre laboratory-based surveillance study in India

2019 ◽  
Vol 74 (5) ◽  
pp. 1260-1268 ◽  
Author(s):  
Ashutosh Singh ◽  
Pradeep K Singh ◽  
Theun de Groot ◽  
Anil Kumar ◽  
Purva Mathur ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Clinical Isolates ◽  
Surveillance Study ◽  
Fluconazole Resistant

Activities of Nanoparticles Against Fluconazole-Resistant Candida parapsilosis in Clinical Isolates

2021 ◽  
Author(s):  
Ensieh Lotfali ◽  
Reza Ghasemi ◽  
Azam Fattahi ◽  
Mahyar Keymaram ◽  
Mohammad Shafiei ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Clinical Isolates ◽  
Fluconazole Resistant

scholarly journals Azasordarins: Susceptibility of Fluconazole-Susceptible and Fluconazole-Resistant Clinical Isolates ofCandida spp. to GW 471558

2001 ◽  
Vol 45 (6) ◽  
pp. 1905-1907 ◽  
Author(s):  
Manuel Cuenca-Estrella ◽  
Emilia Mellado ◽  
Teresa M. Dı́az-Guerra ◽  
Araceli Monzón ◽  
Juan L. Rodrı́guez-Tudela
Keyword(s):  
Candida Albicans ◽  
Candida Glabrata ◽  
Candida Parapsilosis ◽  
Candida Guilliermondii ◽  
Candida Krusei ◽  
Clinical Isolates ◽  
In Vitro Activity ◽  
Fluconazole Resistant ◽  
Candida Lusitaniae

ABSTRACT The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candidaspp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 μg/ml).

scholarly journals Prevalence of Antimicrobial Resistance among Clinical Isolates of Bacteroides fragilis Group in Canada in 2010-2011: CANWARD Surveillance Study

2011 ◽  
Vol 56 (3) ◽  
pp. 1247-1252 ◽  
Author(s):  
James A. Karlowsky ◽  
Andrew J. Walkty ◽  
Heather J. Adam ◽  
Melanie R. Baxter ◽  
Daryl J. Hoban ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Bacteroides Fragilis ◽  
Clinical Isolates ◽  
Surveillance Study ◽  
Content Type ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Amoxicillin Clavulanate ◽  
Bacteroides Fragilis Group ◽  
Bacteroides Ovatus

ABSTRACTClinical isolates of theBacteroides fragilisgroup (n= 387) were collected from patients attending nine Canadian hospitals in 2010-2011 and tested for susceptibility to 10 antimicrobial agents using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution method.B. fragilis(59.9%),Bacteroides ovatus(16.3%), andBacteroides thetaiotaomicron(12.7%) accounted for ∼90% of isolates collected. Overall rates of percent susceptibility were as follows: 99.7%, metronidazole; 99.5%, piperacillin-tazobactam; 99.2%, imipenem; 97.7%, ertapenem; 92.0%, doripenem; 87.3%, amoxicillin-clavulanate; 80.9%, tigecycline; 65.9%, cefoxitin; 55.6%, moxifloxacin; and 52.2%, clindamycin. Percent susceptibility to cefoxitin, clindamycin, and moxifloxacin was lowest forB. thetaiotaomicron(n= 49, 24.5%),Parabacteroides distasonis/P. merdae(n= 11, 9.1%), andB. ovatus(n= 63, 31.8%), respectively. One isolate (B. thetaiotaomicron) was resistant to metronidazole, and two isolates (bothB. fragilis) were resistant to both piperacillin-tazobactam and imipenem. Since the last published surveillance study describing Canadian isolates ofB. fragilisgroup almost 20 years ago (A.-M. Bourgault et al., Antimicrob. Agents Chemother. 36:343–347, 1992), rates of resistance have increased for amoxicillin-clavulanate, from 0.8% (1992) to 6.2% (2010-2011), and for clindamycin, from 9% (1992) to 34.1% (2010-2011).

scholarly journals In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates

1998 ◽  
Vol 42 (2) ◽  
pp. 471-472 ◽  
Author(s):  
M. Hong Nguyen ◽  
Christine Y. Yu
Keyword(s):  
Cryptococcus Neoformans ◽  
Susceptibility Testing ◽  
Clinical Isolates ◽  
Comparative Efficacy ◽  
In Vitro Susceptibility ◽  
In Vitro Susceptibility Testing ◽  
Fluconazole Resistant ◽  
Dose Dependent

ABSTRACT In vitro susceptibility testing for 50 clinical isolates of fluconazole-susceptible or -resistant Cryptococcus neoformans was performed with itraconazole and voriconazole. Voriconazole was more potent than itraconazole for fluconazole-susceptible isolates and as potent as itraconazole for fluconazole-susceptible dose-dependent isolates and for fluconazole-resistant isolates. For fluconazole-resistant isolates, the voriconazole and itraconazole MICs ranged from 1 to 2 μg/ml.

scholarly journals Lack of efficacy of echinocandins against high metabolic activity biofilms of Candida parapsilosis clinical isolates

2020 ◽  
Vol 51 (3) ◽  
pp. 1129-1133 ◽  
Author(s):  
Danilo Yamamoto Thomaz ◽  
Marcia de Souza Carvalho Melhem ◽  
João Nobrega de Almeida Júnior ◽  
Gil Benard ◽  
Gilda Maria Barbaro Del Negro
Keyword(s):  
Metabolic Activity ◽  
Candida Parapsilosis ◽  
Clinical Isolates ◽  
High Metabolic Activity

scholarly journals Clostridium difficile erm(B)-containing elements and the burden on the in vitro fitness

2013 ◽  
Vol 62 (9) ◽  
pp. 1461-1467 ◽  
Author(s):  
François Wasels ◽  
Patrizia Spigaglia ◽  
Fabrizio Barbanti ◽  
Paola Mastrantonio
Keyword(s):  
Clostridium Difficile ◽  
Clinical Isolates ◽  
Surveillance Study ◽  
Conjugative Transposon ◽  
Genetic Organization ◽  
Ribotype 027 ◽  
Pcr Ribotype 027

In Clostridium difficile, resistance to the macrolide-lincosamide-streptogramin B group of antibiotics generally relies on erm(B) genes. In this study, we investigated elements with a genetic organization different from Tn5398, the mobilizable non-conjugative element identified in C. difficile strain 630. Our results suggested that the elements most frequently found in strains isolated during the European surveillance study in 2005 were related to Tn6194, the conjugative transposon recently detected in different C. difficile types, including PCR-ribotype 027. We characterized a Tn6194-like and a novel element rarely found in clinical isolates. A burden on the in vitro fitness of C. difficile was observed after the acquisition of these elements as well as of Tn5398.

Comparison of biofilm-producing ability of clinical isolates of Candida parapsilosis species complex

2019 ◽  
Vol 29 (2) ◽  
pp. 140-146 ◽  
Author(s):  
M. Modiri ◽  
S. Khodavaisy ◽  
A. Barac ◽  
M. Akbari Dana ◽  
L. Nazemi ◽  
...  
Keyword(s):  
Species Complex ◽  
Candida Parapsilosis ◽  
Clinical Isolates
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