scholarly journals Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models

2018 ◽  
Vol 74 (2) ◽  
pp. 432-441 ◽  
Author(s):  
Sofie A M Dhaese ◽  
Andras Farkas ◽  
Pieter Colin ◽  
Jeffrey Lipman ◽  
Veronique Stove ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Predictive Performance ◽  
Pharmacokinetic Models

scholarly journals Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients

2018 ◽  
Vol 51 (4) ◽  
pp. 594-600 ◽  
Author(s):  
Sofie A.M. Dhaese ◽  
Jason A. Roberts ◽  
Mieke Carlier ◽  
Alain G. Verstraete ◽  
Veronique Stove ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients

scholarly journals Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients

2003 ◽  
Vol 57 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Eleonora L. Swart ◽  
Klaas P. Zuideveld ◽  
Joost De Jongh ◽  
Meindert Danhof ◽  
Lambertus G. Thijs ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Population Pharmacokinetics ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Comparative Population

scholarly journals Influence of Mechanical Ventilation on the Pharmacokinetics of Vancomycin Administered by Continuous Infusion in Critically Ill Patients

2017 ◽  
Vol 61 (12) ◽  
Author(s):  
Susanna Edith Medellín-Garibay ◽  
Silvia Romano-Moreno ◽  
Pilar Tejedor-Prado ◽  
Noelia Rubio-Álvaro ◽  
Aida Rueda-Naharro ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Creatinine Clearance ◽  
Continuous Infusion ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Population Pharmacokinetic Model ◽  
Pharmacokinetic Model ◽  
Volume Of Distribution ◽  
Stochastic Simulations ◽  
Population Pharmacokinetic

ABSTRACT Pathophysiological changes involved in drug disposition in critically ill patients should be considered in order to optimize the dosing of vancomycin administered by continuous infusion, and certain strategies must be applied to reach therapeutic targets on the first day of treatment. The aim of this study was to develop a population pharmacokinetic model of vancomycin to determine clinical covariates, including mechanical ventilation, that influence the wide variability of this antimicrobial. Plasma vancomycin concentrations from 54 critically ill patients were analyzed simultaneously by a population pharmacokinetic approach. A nomogram for dosing recommendations was developed and was internally evaluated through stochastic simulations. The plasma vancomycin concentration-versus-time data were best described by a one-compartment open model with exponential interindividual variability associated with vancomycin clearance and the volume of distribution. Residual error followed a homoscedastic trend. Creatinine clearance and body weight significantly dropped the objective function value, showing their influence on vancomycin clearance and the volume of distribution, respectively. Characterization based on the presence of mechanical ventilation demonstrated a 20% decrease in vancomycin clearance. External validation (n = 18) was performed to evaluate the predictive ability of the model; median bias and precision values were 0.7 mg/liter (95% confidence interval [CI], −0.4, 1.7) and 5.9 mg/liter (95% CI, 5.4, 6.4), respectively. A population pharmacokinetic model was developed for the administration of vancomycin by continuous infusion to critically ill patients, demonstrating the influence of creatinine clearance and mechanical ventilation on vancomycin clearance, as well as the implications for targeting dosing rates to reach the therapeutic range (20 to 30 mg/liter).

scholarly journals Temocillin (6 g daily) in critically ill patients: continuous infusion versus three times daily administration

2014 ◽  
Vol 70 (3) ◽  
pp. 891-898 ◽  
Author(s):  
P.-F. Laterre ◽  
X. Wittebole ◽  
S. Van de Velde ◽  
A. E. Muller ◽  
J. W. Mouton ◽  
...  
Keyword(s):  
Continuous Infusion ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Daily Administration
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