scholarly journals A multivariate genetic analysis confirms rs5010528 in the human leucocyte antigen-C locus as a significant contributor to Stevens-Johnson syndrome/toxic epidermal necrolysis susceptibility in a Mozambique HIV population treated with nevirapine

2018 ◽  
Vol 73 (8) ◽  
pp. 2137-2140
Author(s):  
Cinzia Ciccacci ◽  
Cristina Politi ◽  
Sandro Mancinelli ◽  
Fausto Ciccacci ◽  
Francesca Lucaroni ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Toxic Epidermal Necrolysis ◽  
Human Leucocyte Antigen ◽  
Stevens Johnson Syndrome ◽  
Significant Contributor ◽  
Johnson Syndrome ◽  
Multivariate Genetic Analysis

Human leucocyte antigen association of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications in Han Chinese

2021 ◽  
pp. bjophthalmol-2020-317105
Author(s):  
Kevin Sheng-Kai Ma ◽  
Wen Hung Chung ◽  
Yi-Jen Hsueh ◽  
Shin-Yi Chen ◽  
Katsushi Tokunaga ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Allele Frequency ◽  
Carrier Frequency ◽  
Human Leucocyte Antigen ◽  
Han Chinese ◽  
Chinese Patients ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Hla Polymorphism ◽  
Johnson Syndrome

Background/aimsStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) induced by cold medicine (CM) may result in severe ocular complications (SOCs). The purpose of this study was to investigate the human leucocyte antigen (HLA) polymorphism pattern in CM-induced patients with SJS/TEN developing SOCs.MethodsAll participants, including patients with SJS/TEN (n=33) and control patients (n=98), were enrolled through visits to the clinic from 2016 to 2017. SOCs were diagnosed (n=26) via a chart review or eye examination. Patient saliva was collected with commercialised kits and genotyped with PCR assays followed by hybridisation with sequence-specific oligonucleotide (SSO) probes (PCR-SSO) using commercial bead-based typing kits.ResultsIn all patients with SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was significantly higher than that in controls (OR=3.24, 95% CI=1.09 to 9.60, p=0.049), as was the genotype frequency (OR=3.89, 95% CI=1.49 to 10.16, p=0.007). In patients with CM-SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was higher than that in controls (OR=5.56, 95% CI=1.52 to 20.00, p=0.016), as was the allele frequency (OR=6.67, 95% CI=2.33 to 20.00, p=0.001). In patients with CM-SJS/TEN with SOCs, the HLA-B*46:01 allele frequency was significantly higher than that in controls (OR=3.85, 95% CI=1.52 to 10.00, p=0.008).ConclusionsThe HLA-A*02:07 and HLA-B*46:01 alleles were significantly associated with SOCs among Han Chinese patients with CM-SJS/TEN. These findings demonstrate the genetic diversity in SJS pathogenesis among different ethnic groups.

Long-term Progression of Ocular Surface Disease in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Cornea ◽  
2020 ◽  
Vol 39 (6) ◽  
pp. 745-753
Author(s):  
Yamato Yoshikawa ◽  
Mayumi Ueta ◽  
Hideki Fukuoka ◽  
Tsutomu Inatomi ◽  
Isao Yokota ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome
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