scholarly journals Molecular detection of mutations involved in Helicobacter pylori antibiotic resistance in Algeria

2018 ◽  
Vol 73 (8) ◽  
pp. 2034-2038 ◽  
Author(s):  
Meryem Bachir ◽  
Rachida Allem ◽  
Lucie Benejat ◽  
Abedelkarim Tifrit ◽  
Meriem Medjekane ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Molecular Detection ◽  
Detection Of Mutations

scholarly journals Molecular Detection of Antibiotic Resistance in South African Isolates ofHelicobacter pylori

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Nicoline F. Tanih ◽  
Roland N. Ndip
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
South African ◽  
Molecular Detection ◽  
Rapid Diagnosis ◽  
Biopsy Specimens ◽  
H Pylori ◽  
Detection Of Mutations ◽  
Reverse Hybridisation Assay

Rapid diagnosis and treatment ofHelicobacter pylori(H. pylori) presents a challenge. We aimed at investigating the presence ofH. pylori, susceptibility profile, and associated mutations in an effort to validate the effectiveness of GenoType HelicoDR assay inH. pylorityping in our environment. Two hundred and fifty-four biopsy specimens were cultured and DNA extracted from seventy-eight positive cultures using the Qiagen DNA extraction kit. The GenoType Helico DR which employs reverse hybridisation was used to confirm the presence ofH. pylori, determination of its susceptibility to antimicrobials, and detection of mutations conferring resistance to clarithromycin and fluoroquinolones. The organism was isolated from 168/254 (66.1 %) of the specimens by culture. Of the 78 strains used for further investigation, 12/78 (15.38%) were resistant to clarithromycin while 66/78 (84.61%) were susceptible. For fluoroquinolone, 70/78 (89.74%) strains were susceptible while 8 (10.26%) were resistant. Mutations were observed in 17 strains with A2147G being the most prevalent; A2146C and D91N were the least. The reverse hybridisation assay is an easy and fast technique in confirming the presence ofH. pylori, its antimicrobial profile, and associated mutations. Analysis regarding the suitability of this assay forH. pylorityping is warranted in other regions.

scholarly journals Molecular Detection of Antibiotic Resistance of Helicobacter pylori from Gastric Biopsies in Abidjan (Côte d'Ivoire)

2017 ◽  
Vol 20 (1) ◽  
pp. 1-7
Author(s):  
Diplo Bernadette ◽  
Gbonon Valérie ◽  
Guessennd Nathalie ◽  
Yapo Francis ◽  
Kakou Solange ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Molecular Detection ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Gastric Biopsies

scholarly journals Evaluation of a New Test, GenoType HelicoDR, for Molecular Detection of Antibiotic Resistance in Helicobacter pylori

2009 ◽  
Vol 47 (11) ◽  
pp. 3600-3607 ◽  
Author(s):  
E. Cambau ◽  
V. Allerheiligen ◽  
C. Coulon ◽  
C. Corbel ◽  
C. Lascols ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Molecular Detection

scholarly journals Tu1497 NATIONWIDE SURVEY OF HELICOBACTER PYLORI ANTIBIOTIC RESISTANCE IN HIGH PREVALENCE OF GASTRIC CANCER COUNTRY (BHUTAN): A LARGE-SCALE COMMUNITY-BASED STUDY

2020 ◽  
Vol 91 (6) ◽  
pp. AB591-AB592
Author(s):  
Ratha-Korn Vilaichone ◽  
Natsuda Aumpan ◽  
Tomohisa Uchida ◽  
Thawee Ratanachu-ek ◽  
Lotay Tshering ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Large Scale ◽  
Nationwide Survey ◽  
Community Based ◽  
High Prevalence

scholarly journals Sitafloxacin and Garenoxacin May Overcome the Antibiotic Resistance of Helicobacter pylori with gyrA Mutation

2009 ◽  
Vol 53 (4) ◽  
pp. 1720-1721 ◽  
Author(s):  
Hidekazu Suzuki ◽  
Hiroe Muraoka ◽  
Toshifumi Hibi ◽  
Toshihiro Nishizawa
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Gyra Mutation

Culture and Susceptibility of Levofloxacin Resistant H.pylori

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Sameh Mohamed Fahiem Ghaly ◽  
Hany Ali Hussien Abd El-Rahman ◽  
Mohamed Osama Aly Aly ◽  
Ahmed Medhat Youssef Ibrahim Youssef
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Proper Time ◽  
Wide Spectrum ◽  
Signs And Symptoms ◽  
Line Treatment ◽  
Clarithromycin Resistance ◽  
Prior Use ◽  
H Pylori ◽  
Main Factor

Abstract Background Antibiotic resistance in Helicobacter pylori is the major cause of eradication failure. Prevalence of H.pylori antibiotic resistance is increasing worldwide, and it is the main factor affecting efficacy of current therapeutic regimens. Our aim is to investigate H.pylori resistant patients toward Levofloxacin and detect the most effective antibiotic in eradication of H.pylori. Objective To investigate H.pylori resistant patients toward Levofloxacin including regimens and to detect the most effective antibiotic in H.pylori eradication. Patients and Methods The present study aimed to investigate the Susceptibility of Levofloxacin Resistant H.pylori in patients who had been diagnosed and received any regimen including Levofloxacin and still signs and symptoms of H.pylori infection not releaved and after proper time of stoppage of PPI and antibiotics H.pylori Ag in stool still positive at the period from January 2019 to February 2020. Results In the present study we found a wide spectrum of resistance to rates of H. pylori, from nearly negligible rates of Rifampicin (0%), Imipenem (0%), Cefotaxime (2%), Tetracycline (6%), Doxycycline(10%), and Amoxicillin(38%). To high rates resistance to Metronidazole (100%), Erythromycin (72%), Clarithromycin (68%), Azithromycin (60%), Ciprofloxacin (52%), and Levofloxacin (48%). Conclusion Helicobacter pylori is the most common chronic bacterial infection in humans. Antibiotic resistance is a major issue nowadays. Prior use of macrolide antibiotics or metronidazole appears to increase the risk of H. pylori resistance. Clarithromycin resistance appears to be an "absolute" condition that can not be overcome by increasing the macrolide dose. Levofloxacin resistance seems to be increasing. Culture and susceptibility should be done before starting second line treatment.

scholarly journals Phenotypic and Genotypic Assessment of Antibiotic Resistance and Genotyping of vacA, cagA, iceA, oipA, cagE, and babA2 Alleles of Helicobacter pylori Bacteria Isolated from Raw Meat

2020 ◽  
Vol Volume 13 ◽  
pp. 257-272 ◽  
Author(s):  
Zohreh Mashak ◽  
Sedigheh Jafariaskari ◽  
Iman Alavi ◽  
Mohammadhossein Sakhaei Shahreza ◽  
Farhad Safarpoor Dehkordi
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Raw Meat
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