scholarly journals A mathematical model-based analysis of the time–kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa

2018 ◽  
Vol 73 (5) ◽  
pp. 1295-1304 ◽  
Author(s):  
Sherwin K B Sy ◽  
Luning Zhuang ◽  
Huiming Xia ◽  
Marie-Eve Beaudoin ◽  
Virna J Schuck ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Pseudomonas Aeruginosa ◽  
Model Based ◽  
Time Kill ◽  
Kinetics Of ◽  
Model Based Analysis

scholarly journals 27 years of the HIV epidemic amongst men having sex with men in the Netherlands: An in depth mathematical model-based analysis

Epidemics ◽  
2010 ◽  
Vol 2 (2) ◽  
pp. 66-79 ◽  
Author(s):  
Daniela Bezemer ◽  
Frank de Wolf ◽  
Maarten C. Boerlijst ◽  
Ard van Sighem ◽  
T. Deirdre Hollingsworth ◽  
...  
Keyword(s):  
Mathematical Model ◽  
The Netherlands ◽  
Model Based ◽  
Hiv Epidemic ◽  
Sex With Men ◽  
Model Based Analysis

scholarly journals Bactericidal Activity, Absence of Serum Effect, and Time-Kill Kinetics of Ceftazidime-Avibactam against β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa

2014 ◽  
Vol 58 (9) ◽  
pp. 5297-5305 ◽  
Author(s):  
Tiffany R. Keepers ◽  
Marcela Gomez ◽  
Chris Celeri ◽  
Wright W. Nichols ◽  
Kevin M. Krause
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Human Serum ◽  
Bactericidal Activity ◽  
Minimum Bactericidal Concentration ◽  
Wild Type ◽  
Content Type ◽  
Positive Isolate ◽  
New Treatment ◽  
Time Kill ◽  
Kinetics Of

ABSTRACTAvibactam, a non-β-lactam β-lactamase inhibitor with activity against extended-spectrum β-lactamases (ESBLs), KPC, AmpC, and some OXA enzymes, extends the antibacterial activity of ceftazidime against most ceftazidime-resistant organisms producing these enzymes. In this study, the bactericidal activity of ceftazidime-avibactam against 18Pseudomonas aeruginosaisolates and 15Enterobacteriaceaeisolates, including wild-type isolates and ESBL, KPC, and/or AmpC producers, was evaluated. Ceftazidime-avibactam MICs (0.016 to 32 μg/ml) were lower than those for ceftazidime alone (0.06 to ≥256 μg/ml) against all isolates except for 2P. aeruginosaisolates (1blaVIM-positive isolate and 1blaOXA-23-positive isolate). The minimum bactericidal concentration/MIC ratios of ceftazidime-avibactam were ≤4 for all isolates, indicating bactericidal activity. Human serum and human serum albumin had a minimal effect on ceftazidime-avibactam MICs. Ceftazidime-avibactam time-kill kinetics were evaluated at low MIC multiples and showed time-dependent reductions in the number of CFU/ml from 0 to 6 h for all strains tested. A ≥3-log10decrease in the number of CFU/ml was observed at 6 h for allEnterobacteriaceae, and a 2-log10reduction in the number of CFU/ml was observed at 6 h for 3 of the 6P. aeruginosaisolates. Regrowth was noted at 24 h for some of the isolates tested in time-kill assays. These data demonstrate the potent bactericidal activity of ceftazidime-avibactam and support the continued clinical development of ceftazidime-avibactam as a new treatment option for infections caused byEnterobacteriaceaeandP. aeruginosa, including isolates resistant to ceftazidime by mechanisms dependent on avibactam-sensitive β-lactamases.

scholarly journals A model-based analysis of pharmacokinetic–pharmacodynamic (PK/PD) indices of avibactam against Pseudomonas aeruginosa

2019 ◽  
Vol 25 (7) ◽  
pp. 904.e9-904.e16 ◽  
Author(s):  
S.K.B. Sy ◽  
L. Zhuang ◽  
H. Xia ◽  
V.J. Schuck ◽  
W.W. Nichols ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Model Based ◽  
Model Based Analysis

scholarly journals Physiological Association between Limb Ballistocardiogram and Arterial Blood Pressure Waveforms: A Mathematical Model-Based Analysis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Peyman Yousefian ◽  
Sungtae Shin ◽  
Azin Sadat Mousavi ◽  
Chang-Sei Kim ◽  
Barry Finegan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mathematical Model ◽  
Arterial Blood Pressure ◽  
Model Based ◽  
Arterial Blood ◽  
Model Based Analysis

scholarly journals Corrigendum to “27 years of the HIV epidemic amongst men having sex with men in the Netherlands: An in depth mathematical model-based analysis” [Epidemics 2 (2010) 66–79]

Epidemics ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 170
Author(s):  
Daniela Bezemer ◽  
Frank de Wolf ◽  
Maarten C. Boerlijst ◽  
Ard van Sighem ◽  
T. Deirdre Hollingsworth ◽  
...  
Keyword(s):  
Mathematical Model ◽  
The Netherlands ◽  
Model Based ◽  
Hiv Epidemic ◽  
Sex With Men ◽  
Model Based Analysis

scholarly journals Is this the beginning or the end of COVID-19 outbreak in India? A data driven mathematical model-based analysis

2020 ◽  
Author(s):  
Anupam Singh ◽  
Jhilik Dey ◽  
Shivam Bhardwaj
Keyword(s):  
Mathematical Model ◽  
Epidemiological Data ◽  
Data Driven ◽  
Accurate Estimation ◽  
Model Based ◽  
Pessimistic Scenario ◽  
Spread Of Infection ◽  
Model Based Analysis

AbstractIndia has experienced an early and harshest lockdown from 25th March 2020 in response to the outbreak. However, an accurate estimation of the progression of the spread of infection and the level of preparedness to combat this disease are urgently needed. Using a data-based mathematical model, our study has made predictions on the number of cases that are expected to rise in India till 14th June 2020. The epidemiological data of daily cases have been utilized from 25th March (i.e., the first day of lockdown) to 23rd April 2020. In the study, we have stimulated two possible scenarios (optimistic and pessimistic) for the prediction. As per the optimistic approach of modelling, COVID-19 may end in the first week of June 2020 with a total of 77,900 infected cases including 2,442 fatalities. However, the results under the pessimistic scenario are a bit scary as it shows that a total of 283,300 infected cases with 10,180 fatalities till 14th June. To win the battle, 10 weeks of complete lockdown is much needed at least in the infected states and the union territories of India. Alternatively, the isolation of clusters (hotspot regions) is required if India wants a resume of some essential activities.

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