scholarly journals Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

2017 ◽  
Vol 73 (4) ◽  
pp. 933-941 ◽  
Author(s):  
Luzia Holfeld ◽  
Daniel Knappe ◽  
Ralf Hoffmann
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Peptides ◽  
Antibiotic Effect ◽  
Post Antibiotic Effect

scholarly journals Once Daily Dosing of Aminoglycosides in Pediatric Cystic Fibrosis Patients: A Review of the Literature

2008 ◽  
Vol 13 (2) ◽  
pp. 68-75
Author(s):  
Sarah K. Wassil ◽  
Kristie M. Fox ◽  
James W. White
Keyword(s):  
Cystic Fibrosis ◽  
Review Of The Literature ◽  
Nursing Time ◽  
Once Daily ◽  
Development Of Resistance ◽  
Cystic Fibrosis Population ◽  
Antibiotic Effect ◽  
Home Administration ◽  
Post Antibiotic Effect

Patients with cystic fibrosis receive many courses of antibiotic therapy throughout their lifetime. Dosing aminoglycosides once daily has become common practice in many of these individuals. Due to ease of home administration, decreased nursing time, and improved quality of life, this regimen is being increasingly explored in the cystic fibrosis population. Because patients with cystic fibrosis have increased aminoglycoside clearance, once daily dosing may result in a prolonged time during the dosing interval when concentrations of the drug may be undetectable. This makes the use of once daily dosing of these antibiotics in patients with cystic fibrosis controversial. Although aminoglycosides exhibit a post antibiotic effect, the duration of this effect is unknown in humans; therefore, the development of resistance to the aminoglycoside is a concern. This manuscript will review the organisms most commonly associated with a pulmonary exacerbation of cystic fibrosis, the properties of the aminoglycoside that make once daily dosing feasible, the concept of once daily dosing in those with cystic fibrosis and the current literature regarding efficacy, monitoring, toxicity and concerns of resistance with once daily dosing in this population.

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