scholarly journals Impact of recurrent Clostridium difficile infection: hospitalization and patient quality of life

2017 ◽  
Vol 72 (9) ◽  
pp. 2647-2656 ◽  
Author(s):  
Mark H. Wilcox ◽  
Harblas Ahir ◽  
John E. Coia ◽  
Andrew Dodgson ◽  
Susan Hopkins ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Recurrent Clostridium Difficile Infection

scholarly journals Quality of life and utility decrement associated with Clostridium difficile infection in a French hospital setting

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Frédéric Barbut ◽  
Tatiana Galperine ◽  
Philippe Vanhems ◽  
Alban Le Monnier ◽  
Bernard Durand-Gasselin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Hospital Setting ◽  
Utility Decrement ◽  
French Hospital

scholarly journals Impaired Quality of Life, Work, and Activities Among Adults with Clostridium difficile Infection: A Multinational Survey

2018 ◽  
Vol 63 (11) ◽  
pp. 2864-2873 ◽  
Author(s):  
Kirstin Heinrich ◽  
James Harnett ◽  
Jeffrey Vietri ◽  
Richard Chambers ◽  
Holly Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Impaired Quality ◽  
Life Work

scholarly journals Impact of Clostridium difficile Infection on Patients’ Quality of Life: a French Hospital Prospective Study

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S393-S394
Author(s):  
Frederic Barbut ◽  
Tatiana Galperine ◽  
Philippe Vanhems ◽  
Alban Le Monnier ◽  
Viviane Jeanbat ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Regression Analysis ◽  
Clostridium Difficile ◽  
Prospective Study ◽  
Social Relationships ◽  
Clostridium Difficile Infection ◽  
Physical Domain ◽  
Physical Complaints ◽  
The Impact

Abstract Background Few data are available on the impact of episodes of Clostridium difficile infection (CDI) on quality of life. The Cdiff32, a new specific health-related quality of life questionnaire recently validated, allows such a measurement (Garey et al. J Clin Gastroenterol 2016 Sep;50(8):631–7). Methods An observational prospective study was performed in 7 French acute-care facilities in 2016. All consecutive patients presenting with a bacteriologically-confirmed CDI during a hospital stay, regardless of reason for hospitalization, were enrolled. Two instruments were presented to patients at 7(±2) days after CDI diagnosis: the Cdiff32 and a generic questionnaire the EQ-5D-3L. The Cdiff32 comprises 32 self-administered questions about the impact of CDI in 3 broad domains (physical, mental and social). The physical domain differentiates general (6 questions) and specific physical complaints (8 questions). The mental domain comprises 14 questions about current and future anxiety. Four questions cover the impact on social relationships. Each item is scored from 0 (worst score) to 100 (best score) and they are aggregated by domain and globally. Clinical variables were collected to characterize the infection severity (ZAR score) and comorbidities. A regression analysis of the Cdiff32 scores with the EQ-5D-3L was performed. Results 80 patients were enrolled and 3 were excluded because of missing data. The median age was 71 years and 45% were males. The global Cdiff32 score was 50.4 (SD: 17.1) with a large variability among patients (min 18.3, max 90.2). The highest impact of CDI was observed on the general physical complaints (41.6), as well as the level of current anxiety (41.6). The score relating to the social relationships was the highest (63.7). The severity of CDI (as defined by the Zar score) and the global Cdiff32 score were correlated essentially through the physical sub-score (P = 0.0154). Patients with recurrences had a lower mental score compared with patients with an initial episode (P = 0.0582). The regression analysis of global Cdiff32 score and EQ-5D-3L utility score showed a positive relationship (R2=0.317). Conclusion The Cdiff32 allowed to estimate the important impact on quality of life of CDI especially on the physical domain. Disclosures All authors: No reported disclosures.

Self-Administered Home Series Fecal “Minitransplants” for Recurrent Clostridium difficile Infection on a Rectal Remnant

2015 ◽  
Vol 24 (4) ◽  
pp. 531-533 ◽  
Author(s):  
Daniel Popa ◽  
Mihaela Laszlo ◽  
Lidia Ciobanu ◽  
Elena Ucenic ◽  
Manuela Mihalache ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Toxic Megacolon ◽  
Fecal Microbiota ◽  
Recurrent Infections ◽  
Resonance Imaging ◽  
Vaginal Infection ◽  
Fecal Microbiota Transplant ◽  
Recurrent Clostridium Difficile Infection

A fecal microbiota transplant has proved to be an extremely effective method for patients with recurrent infections with Clostridium difficile. We present the case of a 65-year-old female patient with multiple Clostridium difficile infection (CDI) relapses on the rectal remnant, post-colectomy for a CDI-related toxic megacolon. The patient also evidenced associated symptomatic Clostridium difficile vaginal infection. She was successfully treated with serial fecal “minitransplants” (self-administered at home) and metronidazole ovules.Abbreviations: GI: gastrointestinal; MRI: magnetic resonance imaging; CDI: Clostridium difficile infection; FMT: fecal microbiota transplant.

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