scholarly journals Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects

2016 ◽  
Vol 72 (2) ◽  
pp. 515-521 ◽  
Author(s):  
Borje Darpo ◽  
Philip T. Sager ◽  
Prabhavathi Fernandes ◽  
Brian D. Jamieson ◽  
Kara Keedy ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Cardiac Repolarization

Effect of levetiracetam on cardiac repolarization in healthy subjects: A single-dose, randomized, placebo- and active-controlled, four-way crossover study

2008 ◽  
Vol 30 (2) ◽  
pp. 260-270 ◽  
Author(s):  
Réginald Hulhoven ◽  
Dominique Rosillon ◽  
William E. Bridson ◽  
Marie-Anne Meeus ◽  
Edubijes Salas ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Cardiac Repolarization

scholarly journals A thorough QT study to assess the effects of tbo-filgrastim on cardiac repolarization in healthy subjects

2015 ◽  
pp. 2653 ◽  
Author(s):  
Liat Adar ◽  
Noa Avisar ◽  
Andreas Lammerich ◽  
Robert B. Kleiman ◽  
Ofer Spiegelstein
Keyword(s):  
Healthy Subjects ◽  
Cardiac Repolarization ◽  
Thorough Qt Study

Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study

2018 ◽  
Vol 35 (2) ◽  
pp. 210-217
Author(s):  
SeungHwan Lee ◽  
Jun Gi Hwang ◽  
Sang Yeob Park ◽  
Hye Jung Lim ◽  
Sa-Won Lee ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Randomized Crossover Study

scholarly journals Effect of Cabotegravir on Cardiac Repolarization in Healthy Subjects

2016 ◽  
Vol 5 (6) ◽  
pp. 509-516 ◽  
Author(s):  
Yu Lou ◽  
Ann M. Buchanan ◽  
Shuguang Chen ◽  
Susan L. Ford ◽  
Elizabeth Gould ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Cardiac Repolarization

Ibuprofen: Plasma Concentrations in Man

1985 ◽  
Vol 13 (1) ◽  
pp. 68-73 ◽  
Author(s):  
G M E Janssen ◽  
J F Venema
Keyword(s):  
Side Effects ◽  
Crossover Study ◽  
Plasma Levels ◽  
Healthy Subjects ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Repeated Dose ◽  
Similar Range ◽  
The Mean ◽  
Peak Value

The plasma levels of Ibuprofen were measured in five healthy subjects who took 600 mg tablets of Ibuprofen twice daily, three times daily and four times daily in a crossover study. Peak plasma levels were obtained 1 hour after the first dose in all but one subject (slow absorber), the mean peak value being 51·3 μg.ml−1 (range 39·4–63·7 μg.ml−1). After the repeated dose regimens of two, three or four times daily of ibuprofen, the peak levels achieved were in a similar range to those seen after the first dose: Twice daily 39·4–66·4 μg.ml−1 Three times daily 43·6–63·3 μg.ml−1 Four times daily 44·1–58·4 μg.ml−1 There was no evidence of accumulation of the drug and no side-effects occurred during the trial.

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