scholarly journals Dose optimization of voriconazole/anidulafungin combination against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model and response surface analysis: clinical implications for azole-resistant aspergillosis

2016 ◽  
Vol 71 (11) ◽  
pp. 3135-3147 ◽  
Author(s):  
Maria Siopi ◽  
Nikolaos Siafakas ◽  
Sophia Vourli ◽  
Johan W. Mouton ◽  
Loukia Zerva ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Response Surface ◽  
Surface Analysis ◽  
Pharmacodynamic Model ◽  
Response Surface Analysis ◽  
Dose Optimization ◽  
Clinical Implications

scholarly journals In vitro synergy of isavuconazole in combination with colistin against Candida auris

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Patrick Schwarz ◽  
Anne-Laure Bidaud ◽  
Eric Dannaoui
Keyword(s):  
Response Surface ◽  
Surface Analysis ◽  
Concentration Index ◽  
Inhibitory Concentration ◽  
Response Surface Analysis ◽  
Fractional Inhibitory Concentration ◽  
Candida Auris ◽  
Fractional Inhibitory Concentration Index ◽  
Agar Diffusion

AbstractThe in vitro interactions of isavuconazole with colistin were evaluated against 15 clinical Candida auris isolates by a microdilution checkerboard technique based on the EUCAST reference method for antifungal susceptibility testing and by agar diffusion using isavuconazole gradient concentration strips with or without colistin incorporated RPMI agar. Interpretation of the checkerboard results was done by the fractional inhibitory concentration index and by response surface analysis based on the Bliss model. By checkerboard, combination was synergistic for 93% of the isolates when interpretation of the data was done by fractional inhibitory concentration index, and for 80% of the isolates by response surface analysis interpretation. By agar diffusion test, although all MICs in combination decreased compared to isavuconazole alone, only 13% of the isolates met the definition of synergy. Essential agreement of EUCAST and gradient concentration strip MICs at +/− 2 log2 dilutions was 93.3%. Antagonistic interactions were never observed for any technique or interpretation model used.

scholarly journals Response surface analysis of nozzle parameters at supersonic flow through microjets

2021 ◽  
pp. 1-16
Author(s):  
Turki Al-Khalifah ◽  
Abdul Aabid ◽  
Sher Afghan Khan ◽  
Muhammad Hanafi Bin Azami ◽  
Muneer Baig
Keyword(s):  
Supersonic Flow ◽  
Response Surface ◽  
Surface Analysis ◽  
Response Surface Analysis ◽  
Flow Through
Sign in / Sign up

Export Citation Format

Share Document