scholarly journals Natural antimicrobial peptides againstMycobacterium tuberculosis

2015 ◽  
Vol 70 (5) ◽  
pp. 1285-1289 ◽  
Author(s):  
Maria Abedinzadeh ◽  
Mahdieh Gaeini ◽  
Soroush Sardari
Keyword(s):  
Antimicrobial Peptides ◽  
Natural Antimicrobial

The role of natural antimicrobial peptides during infection and chronic inflammation

2017 ◽  
Vol 111 (1) ◽  
pp. 5-26 ◽  
Author(s):  
Xiaojing Xia ◽  
Likun Cheng ◽  
Shouping Zhang ◽  
Lei Wang ◽  
Jianhe Hu
Keyword(s):  
Antimicrobial Peptides ◽  
Chronic Inflammation ◽  
Natural Antimicrobial

scholarly journals Natural Antimicrobial Peptides from Eukaryotic Organisms

10.5772/33293 ◽  
2012 ◽  
Author(s):  
Renaud Conde ◽  
Martha Arguello ◽  
Javier Izquierdo ◽  
Raul Noguez ◽  
Miguel Moreno ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Natural Antimicrobial ◽  
Eukaryotic Organisms

scholarly journals Peptide Antibiotics Developed by Mimicking Natural Antimicrobial Peptides

2017 ◽  
Vol 06 (04) ◽  
Author(s):  
Nihan Unubol ◽  
Suleyman Selim Cinaroglu ◽  
Merve Acikel Elmas ◽  
Sumeyye Akcelik ◽  
Arzu Tugba Ozal Ildeniz ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Peptide Antibiotics ◽  
Natural Antimicrobial

scholarly journals Beyond structural models for the mode of action: How natural antimicrobial peptides affect lipid transport

2021 ◽  
Vol 582 ◽  
pp. 793-802
Author(s):  
Josefine Eilsø Nielsen ◽  
Victoria Ariel Bjørnestad ◽  
Vitaliy Pipich ◽  
Håvard Jenssen ◽  
Reidar Lund
Keyword(s):  
Antimicrobial Peptides ◽  
Mode Of Action ◽  
Structural Models ◽  
Lipid Transport ◽  
Natural Antimicrobial

scholarly journals Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins

2006 ◽  
Vol 6 ◽  
pp. 1241-1246 ◽  
Author(s):  
A. Catania ◽  
G. Colombo ◽  
C. Rossi ◽  
A. Carlin ◽  
A. Sordi ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Mammalian Cells ◽  
Antimicrobial Properties ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Natural Antimicrobial ◽  
Melanocyte Stimulating Hormone ◽  
Evolutionary Spectrum ◽  
The Central Nervous System ◽  
Anti Inflammatory

The natural antimicrobial peptides are ancient host defense effector molecules, present in organisms across the evolutionary spectrum. Several properties of α-melanocyte stimulating hormone (α-MSH) suggested that it could be a natural antimicrobial peptide. α-MSH is a primordial peptide that appeared during the Paleozoic era, long before adaptive immunity developed and, like natural antimicrobial molecules, is produced by barrier epithelia, immunocytes, and within the central nervous system. α-MSH was discovered to have antimicrobial activity against two representative pathogens,Staphylococcus aureusandCandida albicans. The candidacidal influences of α-MSH appeared to be mediated by increases in cell cyclic adenosine monophosphate (cAMP). The cAMP-inducing capacity of α-MSH likely interferes with the yeast's own regulatory mechanisms of this essential signaling pathway. It is remarkable that this mechanism of action in yeast mimics the influences of α-MSH in mammalian cells in which the peptide binds to G-protein-linked melanocortin receptors, activates adenylyl cyclase, and increases cAMP. When considering that most of the natural antimicrobial peptides enhance the local inflammatory reaction, the anti-inflammatory and antipyretic effects of α-MSH confer unique properties to this molecule relative to other natural antimicrobial molecules. Synthetic derivatives, chemically stable and resistant to enzymatic degradation, could form the basis for novel therapies that combine anti-inflammatory and antimicrobial properties.

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