scholarly journals Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing

2014 ◽  
Vol 70 (3) ◽  
pp. 930-940 ◽  
Author(s):  
Alessandro Cozzi-Lepri ◽  
Marc Noguera-Julian ◽  
Francesca Di Giallonardo ◽  
Rob Schuurman ◽  
Martin Däumer ◽  
...  
Keyword(s):  
Virological Failure ◽  
454 Pyrosequencing ◽  
Case Control Study ◽  
Low Frequency ◽  
Case Control ◽  
Drug Resistant ◽  
First Line ◽  
Hiv 1 ◽  
Control Study

scholarly journals Determinants of virological failure among adults on first-line highly active antiretroviral therapy at public health facilities in Kombolcha town, Northeast, Ethiopia: a case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e036223
Author(s):  
Habtamu Mengist Meshesha ◽  
Zelalem Mehari Nigussie ◽  
Anemaw Asrat ◽  
Kebadnew Mulatu
Keyword(s):  
Public Health ◽  
Antiretroviral Therapy ◽  
Virological Failure ◽  
Highly Active Antiretroviral Therapy ◽  
Case Control Study ◽  
Case Control ◽  
First Line ◽  
Highly Active ◽  
Northeast Ethiopia ◽  
Control Study

ObjectiveTo identify determinants of virological failure among HIV-infected adults on first-line highly active antiretroviral therapy at public health facilities in Kombolcha town, Northeast, Ethiopia, in 2019.MethodsAn unmatched case–control study was conducted from April to May 2019. About 130 cases and 259 controls were selected by simple random sampling. Data were extracted from charts of patients using a structured checklist. Multiple logistic regression analysis was performed to identify possible factors. Hosmer-Lemeshow goodness of fit test was used to check the model. Finally, independent predictor variables of virological failure were identified based on adjusted OR (AOR) with 95% CI and a p value of 0.05.ResultsThe odds of virological failure were 2.4-fold (AOR=2.44, 95% CI 1.353 to 4.411) higher in clients aged <35 years compared with older clients, fivefold (AOR=5.00, 95% CI 2.60 to 9.63) higher in clients who did not disclose their HIV status, threefold (AOR=2.99, 95% CI 1.33 to 6.73) higher in clients with poor adherence, and 7.5-fold (AOR=7.51, 95% CI 3.98 to 14.14) higher in clients who had recent CD4 count of ≤250 cells/mm3.Conclusion and recommendationThis study revealed that age, marital status, occupation, disclosure status, baseline functional status, missed clinic visit, current antiretroviral therapy regimen, adherence to treatment and recent CD4 count were significantly associated with virological failure. Therefore, adherence support should be strengthened among clients. Missed clinic visits should also be reduced, as it could help clients better adhere to treatment, and therefore boost their immunity and suppress viral replication.

scholarly journals APOBEC3G expression and HIV-1 infection in Burkina Faso

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Tegwinde Rebeca Compaore ◽  
Serge Theophile Soubeiga ◽  
Abdoul Karim Ouattara ◽  
Damehan Tchelougou ◽  
Cyrille Bisseye ◽  
...  
Keyword(s):  
Burkina Faso ◽  
Case Control Study ◽  
Potent Inhibitor ◽  
Case Control ◽  
Negative Strand ◽  
Minor Alleles ◽  
Viral Cdna ◽  
Hiv 1 ◽  
Control Study ◽  
Apobec3g Expression

APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.

scholarly journals Antenatal HIV-1 RNA load and timing of mother to child transmission; a nested case-control study in a resource poor setting

2010 ◽  
Vol 7 (1) ◽  
Author(s):  
Kerina Duri ◽  
Felicity Z Gumbo ◽  
Knut I Kristiansen ◽  
Nyaradzi E Kurewa ◽  
Munyaradzi P Mapingure ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Resource Poor Setting ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Resource Poor ◽  
Nested Case Control ◽  
Mother To Child ◽  
Hiv 1 ◽  
Control Study

scholarly journals Etiologies and Manifestations of Persistent Diarrhea in Adults with HIV‐1 Infection: A Case‐Control Study in Lima, Peru

2005 ◽  
Vol 191 (1) ◽  
pp. 11-19 ◽  
Author(s):  
César Cárcamo ◽  
Thomas Hooton ◽  
Mark H. Wener ◽  
Noel S. Weiss ◽  
Robert Gilman ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Persistent Diarrhea ◽  
Hiv 1 ◽  
Control Study
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