scholarly journals Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients

2014 ◽  
Vol 69 (10) ◽  
pp. 2809-2818 ◽  
Author(s):  
Christoph Stephan ◽  
Hanna-Mari Baldauf ◽  
Joanne Barry ◽  
Frank A. Giordano ◽  
Cynthia C. Bartholomae ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Treatment Naïve ◽  
Hiv 1 ◽  
Rna And Dna

Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients

AIDS ◽  
2004 ◽  
Vol 18 (14) ◽  
pp. 1925-1931 ◽  
Author(s):  
Sanjay U C Sankatsing ◽  
Suzanne Jurriaans ◽  
Peter van Swieten ◽  
Frank van Leth ◽  
Marion Cornelissen ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Treatment Naïve ◽  
Hiv 1

Cost Effectiveness of Darunavir/ritonavir Combination Antiretroviral Therapy for Treatment-Naive Adults with HIV-1 Infection in Canada

2014 ◽  
Vol 32 (9) ◽  
pp. 903-917 ◽  
Author(s):  
Anita J. Brogan ◽  
Erik Smets ◽  
Josephine A. Mauskopf ◽  
Sarah A. L. Manuel ◽  
Ines Adriaenssen
Keyword(s):  
Cost Effectiveness ◽  
Antiretroviral Therapy ◽  
Combination Antiretroviral Therapy ◽  
Treatment Naïve ◽  
Hiv 1

scholarly journals Evaluation of the HIV-1 drug resistance to elsulfavirine and the effectiveness of it among Russian treatment-naïve patients

2021 ◽  
Vol 12 (5) ◽  
pp. 29-39
Author(s):  
A. A. Kirichenko ◽  
D. E. Kireev ◽  
A. V. Kravchenko ◽  
A. V. Pokrovskaya ◽  
U. A. Kuimova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Virological Failure ◽  
Resistance Testing ◽  
Study Group ◽  
Resistance Mutations ◽  
Drug Resistance Testing ◽  
The Third ◽  
Treatment Naïve ◽  
Hiv 1

The aim of the study: to analyze the prevalence of resistance mutations to elsulfavirine and to evaluate the effectiveness of it among HIV-infected treatment-naïve patients in real clinical practice.Materials and methods. The study included 578 patients with HIV infection, which divided into 3 groups. The first group is 354 HIV-infected treatment-naïve patients for whom HIV-1 nucleotide sequences were obtained as part of routine drug resistance testing. The second study group included 111 HIV-infected treatment-naïve patients, tested for drug resistance before the antiretroviral therapy containing elsulfavirine. The third study group included 113 HIV-infected treatment-naïve patients, each of whom was assigned a treatment regimen containing elsulfavirine without prior drug resistance testing. The observation period for patients of the second and third groups who received treatment was 24 weeks. To assess the effectiveness of antiretroviral therapy in patients, viral load, CD4+ T-cell counts, and adherence to therapy were assessed. HIV-1 subtypes and drug resistance mutations were determined using the Stanford HIV Resistance Database (v. 8.9-1). To clarify the results of subtyping, phylogenetic analysis of nucleotide sequences was carried out using the MEGA program (v. 6.0).Results. The prevalence of mutations associated with decreased susceptibility to elsulfavirine among HIV-infected treatment-naïve patients was 1.7% and 4.5% for the first and second groups of patients, respectively. All of the patients have only single resistance mutations which, according to the results of preclinical studies, cannot cause drug resistance. The use of elsulfavirine in real clinical practice among treatment-naïve patients has demonstrated good virological and immunological efficacy of the drug. As a result of 24 weeks of therapy in patients of the second group, no treatment ineffectiveness, and the development of drug resistance were observed. Among the patients of the third group, 6 patients (5.3%) have the virological failure of therapy associated with the resistance to the used drugs. All patients with virological failure had a resistance mutation profile associated with a high level of drug resistance to one of the drugs in the treatment regimen, lamivudine. Additionally, 1 patient had a combination of mutations that reduce susceptibility to elsulfavirine, and 4 patients had mutations that can reduce susceptibility to elsulfavirine in combination with other mutations.Conclusion. The low prevalence of mutations associated with a decrease in susceptibility to elsulfavirine and the absence of combinations of mutations make it possible to predict the successful use of this drug for Russian treatment-naïve patients. Reported cases of virological failure of antiretroviral therapy are difficult to interpret in the context of elsulfavirine due to the lack of an exact list of mutations and their combinations, and associations with the degree of resistance to it. This study describes for the first time the mutation profiles in patients with virological failure of therapy containing elsulfavirine and demonstrates the necessity of the further study of drug resistance profile to drug in vitro and in vivo.

Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men

AIDS ◽  
2000 ◽  
Vol 14 (5) ◽  
pp. F69-F75 ◽  
Author(s):  
Thomas M. Lampinen ◽  
Cathy W. Critchlow ◽  
Jane M. Kuypers ◽  
Carla S. Hurt ◽  
Paul J. Nelson ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Homosexual Men ◽  
Hiv 1 ◽  
Rna And Dna

scholarly journals Long-Term Efficacy, Tolerability, and Renal Safety of Atazanavir/Ritonavir-based Antiretroviral Therapy in a Cohort of Treatment-Naïve Patients with HIV-1 Infection: the REMAIN Study

2016 ◽  
Vol 17 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Eugénio Teófilo ◽  
Nuno Rocha-Pereira ◽  
Birger Kuhlmann ◽  
Antonio Antela ◽  
Heribert Knechten ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Term Efficacy ◽  
Treatment Naïve ◽  
Hiv 1 ◽  
Renal Safety

scholarly journals High Treatment Success Rates When Switching to Once Daily Nevirapine Containing Antiretroviral Therapy

2008 ◽  
Vol 2 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Andrew Benzie ◽  
Brett Marett ◽  
Nicola E Mackie ◽  
Alan Winston
Keyword(s):  
Antiretroviral Therapy ◽  
Treatment Success ◽  
First Year ◽  
Success Rates ◽  
Once Daily ◽  
Hiv Rna ◽  
Virological Outcome ◽  
Treatment Naïve ◽  
High Treatment ◽  
Hiv 1

Introduction Two recent studies have highlighted low rates of virological response to once daily nevirapine containing combination antiretroviral therapy (CART) in treatment naïve HIV-1 infected subjects. Aim We assessed factors associated with treatment responses in a cohort of HIV-1 infected, therapy naïve individuals, commencing nevirapine CART with two nucleoside reverse transcriptase inhibitors (NRTI) containing either lamivudine or emtricitabine. Results Between January 2002 and 2006, 173 subjects (80 female) met the study inclusion criteria. All subjects initially commenced on twice daily nevirapine with six different NRTI backbones. Mean follow up was 802 days. 49 (28%) subjects switched to once daily nevirapine, 23 (13%) within the first year. After 48 weeks of therapy, HIV RNA was < 50 copies/mL in 154/173 subjects (89%). A trend was observed towards improved virological outcome (HIV RNA < 50 copies/mL) and switching to once daily nevirapine during the first year of therapy (p=0.051). Conclusion Whilst awaiting the results of prospective studies assessing once daily nevirapine, our data describe high treatment success rates and good safety responses when switching to once daily nevirapine.

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