The Balkan region: NDM-1-producing Klebsiella pneumoniae ST11 clonal strain causing outbreaks in Greece

Evangelia Voulgari; Constantina Gartzonika; Georgia Vrioni; Lida Politi; Efthalia Priavali; Stamatina Levidiotou-Stefanou; Athanassios Tsakris

doi:10.1093/jac/dku105

The Balkan region: NDM-1-producing Klebsiella pneumoniae ST11 clonal strain causing outbreaks in Greece

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dku105 ◽

2014 ◽

Vol 69 (8) ◽

pp. 2091-2097 ◽

Cited By ~ 55

Author(s):

Evangelia Voulgari ◽

Constantina Gartzonika ◽

Georgia Vrioni ◽

Lida Politi ◽

Efthalia Priavali ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Clonal Strain ◽

Balkan Region

Download Full-text

TEM Derivative-Producing Enterobacter aerogenes Strains: Dissemination of a Prevalent Clone

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.46.4.1128-1131.2002 ◽

2002 ◽

Vol 46 (4) ◽

pp. 1128-1131 ◽

Cited By ~ 27

Author(s):

P. Dumarche ◽

C. De Champs ◽

D. Sirot ◽

C. Chanal ◽

R. Bonnet ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Enterobacter Aerogenes ◽

Clonal Strain ◽

Extended Spectrum ◽

Strain Dependent

ABSTRACT TEM-24 (CAZ-6) extended-spectrum β-lactamase (ESBL) was detected in 1988 in Clermont-Ferrand, France, in Klebsiella pneumoniae (bla TEM-24) and Enterobacter aerogenes (bla TEM-24b), and since 1994, a TEM-24-producing E. aerogenes clonal strain has been observed elsewhere in the country. To determine if the spread of this clonal strain was restricted to TEM-24-producing E. aerogenes strains, 84 E. aerogenes strains (non-TEM/SHV-producing strains, TEM-1- or -2-producing strains, and different ESBL-producing strains), isolated from 1988 to 1999 in Clermont-Ferrand (n = 59) and in 11 other French hospitals in 1998 (n = 25), were studied. A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types).

Download Full-text

Hospital outbreak due to a Klebsiella pneumoniae ST147 clonal strain co-producing KPC-2 and VIM-1 carbapenemases in a tertiary teaching hospital in Northern Greece

International Journal of Antimicrobial Agents ◽

10.1016/j.ijantimicag.2018.04.004 ◽

2018 ◽

Vol 52 (3) ◽

pp. 331-337 ◽

Cited By ~ 11

Author(s):

Efthymia Protonotariou ◽

Aggeliki Poulou ◽

Lida Politi ◽

Ioannis Sgouropoulos ◽

Simeon Metallidis ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Teaching Hospital ◽

Northern Greece ◽

Hospital Outbreak ◽

Clonal Strain ◽

Tertiary Teaching ◽

Tertiary Teaching Hospital

Download Full-text

A Case of New Delhi Metallo-β-Lactamase 1 (NDM-1)-Producing Klebsiella pneumoniae with Putative Secondary Transmission from the Balkan Region in the Netherlands

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00111-12 ◽

2012 ◽

Vol 56 (5) ◽

pp. 2790-2791 ◽

Cited By ~ 17

Author(s):

Teysir Halaby ◽

Ascelijn E. Reuland ◽

Nashwan al Naiemi ◽

Anais Potron ◽

Paul H. M. Savelkoul ◽

...

Keyword(s):

The Netherlands ◽

Klebsiella Pneumoniae ◽

New Delhi ◽

Secondary Transmission ◽

Balkan Region

Download Full-text

The structure of the core region of the lipopolysaccharide from Klebsiella pneumoniae O3 3-Deoxy-alpha-D-manno-octulosonic acid (alpha-Kdo) residue in the outer part of the core, a common structural element of Klebsiella pneumoniae O1, O2, O3, O4, O5, O8, and O12 lipopolysaccharides

European Journal of Biochemistry ◽

10.1046/j.1432-1033.2001.02047.x ◽

2001 ◽

Vol 268 (6) ◽

pp. 1722-1729 ◽

Cited By ~ 3

Author(s):

Evgeny Vinogradov ◽

Maciej Cedzynski ◽

Andrzej Ziolkowski ◽

Anna Swierzko

Keyword(s):

Klebsiella Pneumoniae ◽

Outer Part ◽

Core Region ◽

Structural Element ◽

The Core

Download Full-text

Is the antigenic nonapeptide of the HSP60 of Klebsiella pneumoniae the triggering factor in ankylosing spondylitis?

Immunology Letters ◽

10.1016/s0165-2478(97)88073-x ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 306

Author(s):

E García-Latorre

Keyword(s):

Ankylosing Spondylitis ◽

Klebsiella Pneumoniae ◽

Triggering Factor

Download Full-text

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642520 ◽

1994 ◽

Vol 71 (06) ◽

pp. 768-772 ◽

Cited By ~ 14

Author(s):

Gerhard Dickneite ◽

Jörg Czech

Keyword(s):

Septic Shock ◽

Klebsiella Pneumoniae ◽

Organ Failure ◽

Therapeutic Effect ◽

Disseminated Intravascular Coagulation ◽

Post Infection ◽

Thrombin Inhibitor ◽

Bolus Administration ◽

Bacterial Burden ◽

Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

Download Full-text