scholarly journals Determinants of hepatocellular carcinoma in cirrhotic patients treated with nucleos(t)ide analogues for chronic hepatitis B

2014 ◽  
Vol 69 (7) ◽  
pp. 1920-1927 ◽  
Author(s):  
Y.-C. Hsu ◽  
C.-Y. Wu ◽  
H.-Y. Lane ◽  
C.-Y. Chang ◽  
C.-M. Tai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cirrhotic Patients

scholarly journals Non-invasive imaging criteria for the diagnosis of hepatocellular carcinoma in non-cirrhotic patients with chronic hepatitis B

JHEP Reports ◽  
2021 ◽  
pp. 100364
Author(s):  
Carlos Moctezuma-Velázquez ◽  
Sara Lewis ◽  
Karen Lee ◽  
Salvatore Amodeo ◽  
Josep M. Llovet ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
Cirrhotic Patients

scholarly journals Effective viral suppression is necessary to reduce hepatocellular carcinoma development in cirrhotic patients with chronic hepatitis B

Medicine ◽  
2017 ◽  
Vol 96 (44) ◽  
pp. e8454 ◽  
Author(s):  
Wei Zhang ◽  
Xiaoming Wang ◽  
Yu Wang ◽  
Xinyan Zhao ◽  
Weijia Duan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Viral Suppression ◽  
Cirrhotic Patients

Older Age and High Α-fetoprotein Predict Higher Risk of Hepatocellular Carcinoma in Chronic Hepatitis B-Related Cirrhotic Patients Receiving Nucleos(T)ide Analogue Therapy: A Retrospective Cohort Study

2021 ◽  
Author(s):  
Ching-Chih Hu ◽  
Cheng-Hao Weng ◽  
Chih-Lang Lin ◽  
Pei-Hung Chang ◽  
Man-Chin Hua ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Incidence Rate ◽  
Chronic Hepatitis B ◽  
Cox Regression ◽  
Annual Incidence ◽  
Cox Regression Analysis ◽  
Cirrhotic Patients

Abstract Background: Nucleos(t)ide analogues (NUCs) were proved to reduce hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB) infection, but data was limited on the efficacy in the CHB patients with cirrhosis. Methods: We retrospectively analyzed data from 447 patients with CHB-related cirrhosis, who initiated tenofovir/entecavir therapy during April 2007 and August 2013. They were divided into HCC (n=48) and non-HCC (n=399) groups. The mean follow-up period was 63.2 ± 34.2 months.Results: Forty-eight patients (10.7%) developed HCC during surveillance. The annual incidence rate of HCC was 2.04 (95% CI: 1.52–2.68) per 100 person-year. The cumulative incidence of HCC was 0.9%, 9.8% and 22.1% at the 1, 5 and 10 years, respectively. Significant predictors for HCC identified using multiple Cox regression analysis were age ≥50 years (hazard ratio [HR]: 2.34, 95% confidence interval [CI] = 1.08–5.1) and α-fetoprotein (AFP) ≥8 ng/ml (HR: 2.05, 95% CI = 1.1–3.84). The incidence rate of HCC was further analyzed in subgroups according to the risk factors identified by multivariate cox regression. The incidence rate of HCC was 8.67-fold higher in patients with age ≥50 years and AFP ≥8 ng/ml (3.14 per 100 person-year, 95% CI = 1.99–4.72) than those with age <50 years and AFP <8 ng/ml (0.36 per 100 person-year, 95% CI = 0.06–1.19).Conclusion: The cirrhotic CHB patients with age <50 years and AFP <8 ng/ml have the lowest annual incidence of HCC. However, the cirrhotic patients with age ≥50 years or/and AFP ≥8 ng/ml have significantly higher risk for HCC and warrant careful surveillance schedule for HCC development.

scholarly journals Role of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tyng-Yuan Jang ◽  
Yu-Ju Wei ◽  
Ta-Wei Liu ◽  
Ming-Lun Yeh ◽  
Shu-Fen Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Nucleoside Analogues ◽  
Hepatitis D ◽  
Hepatitis D Virus ◽  
Cirrhotic Patients ◽  
Hdv Infection

AbstractHepatitis D virus (HDV) infection increases the risk of hepatocellular carcinoma (HCC) in the natural course of chronic hepatitis B (CHB) patients. Its role in patients treated with nucleotide/nucleoside analogues (NAs) is unclear. We aimed to study the role of hepatitis D in the development of HCC in CHB patients treated with NAs. Altogether, 1349 CHB patients treated with NAs were tested for anti-HDV antibody and RNA. The incidence and risk factors of HCC development were analyzed. Rates of anti-HDV and HDV RNA positivity were 2.3% and 1.0%, respectively. The annual incidence of HCC was 1.4 per 100 person-years after a follow-up period of over 5409.5 person-years. The strongest factor association with HCC development was liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI] 9.98/5.11–19.46, P < 0.001), followed by HDV RNA positivity (HR/ CI 5.73/1.35–24.29, P = 0.02), age > 50 years old (HR/CI 3.64/2.03–6.54, P < 0.001), male gender (HR/CI 2.69/1.29–5.60, P: 0.01), and body mass index (BMI, HR/CI 1.11/1.03–1.18, P = 0.004). The 5-year cumulative incidence of HCC was 7.3% for patients with HDV RNA negativity compared to that of 22.2% for patients with HDV RNA positivity (P = 0.01). In the subgroup of cirrhotic patients, the factors associated with HCC development were HDV RNA positivity (HR/CI 4.45/1.04–19.09, P = 0.04) and BMI (HR/CI 1.11/1.03–1.19, P = 0.01). HDV viremia played a crucial role in HCC development in CHB patients who underwent NA therapy.

scholarly journals Annual Incidence for Hepatocellular Carcinoma (HCC) in Non-Cirrhotic Patients With Chronic Hepatitis B (CHB) and Cirrhotic Patients of All Etiologies

2011 ◽  
Vol 140 (5) ◽  
pp. S-920
Author(s):  
Ailinh L. Do ◽  
Carrie R. Wong ◽  
Vincent G. Nguyen ◽  
Ruel T. Garcia ◽  
Huy N. Trinh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Annual Incidence ◽  
Cirrhotic Patients

Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B

2016 ◽  
Vol 20 (9) ◽  
pp. 535-543 ◽  
Author(s):  
Yuan-Qing Zhang ◽  
Li-Jun Peng ◽  
Yi-Rong Cao ◽  
Zhi-Ping Zeng ◽  
Yu-Jing Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cirrhotic Patients
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