scholarly journals Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells

2013 ◽  
Vol 69 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Liang Shan ◽  
Sifei Xing ◽  
Hung-Chih Yang ◽  
Hao Zhang ◽  
Joseph B. Margolick ◽  
...  
Keyword(s):  
T Cells ◽  
Histone Deacetylase ◽  
Cd4 T Cells ◽  
Histone Deacetylase Inhibitors ◽  
Latent Hiv ◽  
Hiv 1

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression in CD4+ T-cells and monocytes and induces latent HIV-1 expression in vitro

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 61
Author(s):  
Shay Matalon ◽  
Brent E. Palmer ◽  
Marcel F. Nold ◽  
Antonio Furlan ◽  
Gianluca Fossati ◽  
...  
Keyword(s):  
T Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Cd4 T Cells ◽  
Ccr5 Expression ◽  
Deacetylase Inhibitor ◽  
Latent Hiv ◽  
Hiv 1

scholarly journals Histone deacetylase inhibitors butyrate and bufexamac inhibit de novo HIV-1 infection in CD4 T-cells

2020 ◽  
Author(s):  
Lin Chen ◽  
Ariane Zutz ◽  
Julia Phillippou-Massier ◽  
Tim Liebner ◽  
Oliver T. Keppler ◽  
...  
Keyword(s):  
T Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
De Novo ◽  
Treatment Strategies ◽  
Proteome Analysis ◽  
Global Changes ◽  
Hiv Replication ◽  
Latent Hiv ◽  
Hiv 1

AbstractWhile current combined antiretroviral therapy (cART) allows control of HIV replication in patients and effectively suppresses plasma viral loads, it is unable to target latent reservoirs, which are responsible for virus rebound after discontinuation of therapy. Several histone deacetylase inhibitors (HDACIs) have been shown to target reservoirs and to reactivate latent HIV. While this effect is highly desired, it carries the risk that HIV-1 may be reactivated in tissue compartments were cART concentrations are insufficient and thus leading to de novo infections in this sites. To address this concern, we evaluated the effect of different HDACIs for their ability to reverse HIV latency and to modulate de novo infections. Two of the inhibitors, sodium butyrate and bufexamac, significantly inhibited de novo HIV-1 infection in activated CD4+ T-cells. Transcriptome and proteome analysis indicated global changes of protein abundancies, exhibited reduced proliferation of CD4+ T-cells, and revealed butyrate-based proteasomal degradation of EP300, an important factor for HIV-1 replication. Our results disclose new potential treatment strategies and minimizes the concern of potential reservoir reseeding by HDACIs.

scholarly journals Reactivation of latent HIV-1 in central memory CD4+ T cells through TLR-1/2 stimulation

Retrovirology ◽  
2013 ◽  
Vol 10 (1) ◽  
pp. 119 ◽  
Author(s):  
Camille L Novis ◽  
Nancie M Archin ◽  
Maria J Buzon ◽  
Eric Verdin ◽  
June L Round ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Central Memory ◽  
Latent Hiv ◽  
Memory Cd4 T Cells ◽  
Hiv 1

scholarly journals Endothelial Cell Stimulation Overcomes Restriction and Promotes Productive and Latent HIV-1 Infection of Resting CD4+ T Cells

2013 ◽  
Vol 87 (17) ◽  
pp. 9768-9779 ◽  
Author(s):  
A. Shen ◽  
J. J. Baker ◽  
G. L. Scott ◽  
Y. P. Davis ◽  
Y.-Y. Ho ◽  
...  
Keyword(s):  
T Cells ◽  
Endothelial Cell ◽  
Cd4 T Cells ◽  
Cell Stimulation ◽  
Latent Hiv ◽  
Hiv 1

scholarly journals An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

2013 ◽  
Vol 9 (12) ◽  
pp. e1003834 ◽  
Author(s):  
Celsa A. Spina ◽  
Jenny Anderson ◽  
Nancie M. Archin ◽  
Alberto Bosque ◽  
Jonathan Chan ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Cell Model ◽  
Model Systems ◽  
Multiple Cell ◽  
Latent Hiv ◽  
Hiv 1
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