scholarly journals Acute psychosis related to use of trimethoprim/sulfamethoxazole in the treatment of HIV-infected patients with Pneumocystis jirovecii pneumonia: a multicentre, retrospective study

2012 ◽  
Vol 67 (11) ◽  
pp. 2749-2754 ◽  
Author(s):  
K.-Y. Lee ◽  
C.-H. Huang ◽  
H.-J. Tang ◽  
C.-J. Yang ◽  
W.-C. Ko ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Acute Psychosis ◽  
Multicentre Retrospective Study

scholarly journals Diagnostic accuracy of (1→3)-β-D-glucan to predict Pneumocystis jirovecii pneumonia in non-HIV-infected patients

2020 ◽  
Vol 54 (2) ◽  
pp. 221-226
Author(s):  
Petra Rogina ◽  
Miha Skvarc
Keyword(s):  
Retrospective Study ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Lower Respiratory Tract ◽  
Pneumocystis Jirovecii ◽  
Cape Cod ◽  
Direct Immunofluorescence ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Radiological Findings ◽  
Serum Samples

AbstractBackgroundPneumocystis jirovecii pneumonia (PCP) is a common and potentially fatal opportunistic infection in immunocompromised non-HIV individuals. There are problems with clinical and diagnostic protocols for PCP that lack sensitivity and specificity. We designed a retrospective study to compared several methods that were used in diagnostics of PCP.Patients and methodsOne hundred and eight immunocompromised individuals with typical clinical picture for PCP and suspicious radiological findings were included in the study. Serum samples were taken to measure the values of (1→3)-β-D-glucan (Fungitell, Associates of Cape Cod, USA). Lower respiratory tract samples were obtained to perform direct immunofluorescence (DIF, MERIFLUOR® Pneumocystis, Meridian, USA) stain and real-time PCR (qPCR).ResultsFifty-four (50%) of the 108 patients in our study had (1→3)-β-D-glucan > 500 pg/ml. Patients that had (1→3)-β-D-glucan concentrations < 400 pg/ml in serum, had mean threshold cycles (Ct) 35.43 ± 3.32 versus those that had (1→3)-β-D-glucan concentrations >400 pg/mL and mean Ct of 28.97 ± 5.27 (P < 0.001). If we detected P. jirovecii with DIF and qPCR than PCP was proven. If the concentration of (1→3)-β-D-glucan was higher than 400 pg/ml and Ct of qPCR was below 28.97 ± 5.27 than we have been able be certain that P. jirovecii caused pneumonia (odds ratio [OR] 2.31, 95% confidence interval [CI] 1.62–3.27, P < 0.001).ConclusionsMeasurement of (1→3)-β-D-glucan or qPCR alone could not be used to diagnose PCP. Diagnostic cut-off value for (1→3)-β-D-glucan > 400pg/ml and qPCR below 30 Ct, allow us to conclude that patient has PCP. If the values of (1→3)-β-D-glucan are < 400 pg/ml and qPCR is above 35 Ct than colonization with P. jirovecii is more possible than PCP.

Pneumocystis jirovecii pneumonia in children. A retrospective study in a single center over three decades

2020 ◽  
Vol 38 (3) ◽  
pp. 111-118
Author(s):  
Jorge García-Moreno ◽  
Susana Melendo-Pérez ◽  
María Teresa Martín-Gómez ◽  
Marie Antoinette Frick ◽  
Joan Balcells-Ramírez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Single Center

Comparison of Blood (1->3)-β-D-Glucan Levels in AIDS-Related Pneumocystis jirovecii Pneumonia and AIDS-Related Progressive Disseminated Histoplasmosis

2021 ◽  
Author(s):  
Michael Saccente ◽  
Gayathri Krishnan
Keyword(s):  
Retrospective Study ◽  
Respiratory Symptoms ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Disseminated Histoplasmosis ◽  
Progressive Disseminated Histoplasmosis ◽  
Glucan B

Abstract In this retrospective study, (1-&gt;3)-β-D-glucan (B-glucan) was an unreliable marker for AIDS-related Pneumocystis jirovecii pneumonia (PCP) because a high percentage of participants with progressive disseminated histoplasmosis and respiratory symptoms had a positive B-glucan result. Where histoplasmosis is common attributing B-glucan positivity to PCP without further testing risks misdiagnosis.

Pneumocystis jirovecii pneumonia in children. A retrospective study in a single center over three decades

2020 ◽  
Vol 38 (3) ◽  
pp. 111-118 ◽  
Author(s):  
Jorge García-Moreno ◽  
Susana Melendo-Pérez ◽  
María Teresa Martín-Gómez ◽  
Marie Antoinette Frick ◽  
Joan Balcells-Ramírez ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Single Center
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