scholarly journals Association between the IL28B genotype and hepatitis C viral kinetics in the early days of treatment with pegylated interferon plus ribavirin in HIV/HCV co-infected patients with genotype 1 or 4

2011 ◽  
Vol 67 (1) ◽  
pp. 202-205 ◽  
Author(s):  
A. Rivero-Juarez ◽  
A. Camacho Espejo ◽  
I. Perez-Camacho ◽  
K. Neukam ◽  
A. Caruz ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Pegylated Interferon ◽  
Il28b Genotype ◽  
Genotype 1 ◽  
Viral Kinetics ◽  
Pegylated Interferon Plus Ribavirin

scholarly journals Antiviral treatment of hepatitis C in Serbian prison setting: Medical treatment outcomes and patients’ adherence

2016 ◽  
Vol 69 (3-4) ◽  
pp. 85-91 ◽  
Author(s):  
Jasmina Simonovic-Babic ◽  
Ksenija Bojovic ◽  
Dragan Delic ◽  
Natasa Katanic ◽  
Nikola Mitrovic ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Viral Infection ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Antiviral Treatment ◽  
Pegylated Interferon ◽  
Interferon Alfa ◽  
Genotype 1 ◽  
Pegylated Interferon Plus Ribavirin ◽  
Pegylated Interferon Alfa

Introduction. Seroprevlence of chronic hepatitis C viral infection in correctional facilities ranges from 16% to 49%. However, there are only very limited data available on the course of hepatitis C viral infection and outcomes of treatment with pegylated interferon plus ribavirin in correctional settings. The aim of this study was to assess the feasibility and effectiveness of use of pegylated interferon plus ribavirin treatment in the Serbian correctional setting. Material and Methods. The study sample consisted of the patients with hepatitis C hospitalized in the Special Hospital for Prisoners in Belgrade (Serbia) during 2007-2013. Health authorities approved treatment for 32 patients out of 76 treatment-naive patients referred to this institution. The patients (N=32) received 180 mcg pegylated interferon alfa-2a once a week plus oral ribavirin in dosage of 800mg or 1000/1200 mg/day for 24 or 48-week treatment. All patients who completed therapy were assessed at the end of an additional 24-week treatment-free period for a sustained virological response. Results. Sustained virological response was achieved in 53.8% of hepatitis C viral infection genotype 1 patients and in 73.3% and 66.6% of patients with hepatitis C viral infection genotype 3 and 4, respectively. One patient with mixed genotype (1, 2) did not achieve sustained virological response. The overall safety profile of the treatment regimen was very good. The incidence of influenza-like symptoms and depression were low. A serious adverse event was recorded only in 6.4% of patients. Conclusion. The results showed that pegylated interferon alfa-2a plus ribavirin given once a week was well tolerated among prisoners and the regimen had the same adherence and effectiveness as in general population.

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