scholarly journals In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model

2008 ◽  
Vol 62 (6) ◽  
pp. 1326-1331 ◽  
Author(s):  
Y. Morinaga ◽  
K. Yanagihara ◽  
S. Nakamura ◽  
K. Yamamoto ◽  
K. Izumikawa ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Infection Model ◽  
In Vivo Efficacy

scholarly journals In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model

2011 ◽  
Vol 17 (3) ◽  
pp. 318-321 ◽  
Author(s):  
Nobuko Araki ◽  
Katsunori Yanagihara ◽  
Yoshitomo Morinaga ◽  
Koichi Yamada ◽  
Yasuaki Yamada ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Infection Model ◽  
In Vivo Efficacy

Study of the Effects of AM-1155 in a Rat Chronic Respiratory Tract Infection Model with Pseudomonas aeruginosa

Drugs ◽  
1995 ◽  
Vol 49 (Supplement 2) ◽  
pp. 253-255 ◽  
Author(s):  
A. Sato ◽  
H. Kitazawa ◽  
K. Chida ◽  
H. Hayakawa ◽  
M. Iwata
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Infection Model

Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis

1983 ◽  
Vol 12 (suppl A) ◽  
pp. 313-323 ◽  
Author(s):  
H. Permin ◽  
C. Koch ◽  
N. Heiby ◽  
H. O. Christensen ◽  
A. F. Moller ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection

scholarly journals Role of Bordetella O Antigen in Respiratory Tract Infection

2003 ◽  
Vol 71 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Valorie C. Burns ◽  
Elizabeth J. Pishko ◽  
Andrew Preston ◽  
Duncan J. Maskell ◽  
Eric T. Harvill
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Human Pathogen ◽  
O Antigen ◽  
Highly Sensitive ◽  
Major Surface

ABSTRACT Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive immunity. The membrane-distal repeated carbohydrate structure of LPS, the O antigen, can prevent antibody functions and may vary as a mechanism of immune evasion. Genes of the wbm locus are required for the assembly of O antigen on the animal pathogen Bordetella bronchiseptica and the human pathogen B. parapertussis. However, the important human pathogen B. pertussis lacks these genes and a number of in vitro and in vivo characteristics associated with O antigen in other organisms. To determine the specific functions of O antigen in these closely related Bordetella subspecies, we compared wbm deletion (Δwbm) mutants of B. bronchiseptica and B. parapertussis in a variety of assays relevant to natural respiratory tract infection. Complement was not activated or depleted by wild-type bordetellae expressing O antigen, but both Δwbm mutants activated complement and were highly sensitive to complement-mediated killing in vitro. Although the O-antigen structures appear to be substantially similar, the two mutants differed strikingly in their defects within the respiratory tract. The B. parapertussis Δwbm mutant was severely defective in colonization of the tracheas and lungs of mice, while the B. bronchiseptica Δwbm mutant showed almost no defect. While in vitro characteristics such as serum resistance may be attributable to O antigen directly, the role of O antigen during infection appears to be more complex, possibly involving factors differing among the closely related bordetellae or different interactions between each one and its host.

Intranasal immunisation with conjugate vaccine protects mice from systemic and respiratory tract infection with Pseudomonas aeruginosa

Vaccine ◽  
2006 ◽  
Vol 24 (20) ◽  
pp. 4333-4342 ◽  
Author(s):  
Adrian W. Zuercher ◽  
Michael P. Horn ◽  
Hong Wu ◽  
Zhijun Song ◽  
Cathrine J. Bundgaard ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Conjugate Vaccine ◽  
Intranasal Immunisation
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