A randomized, controlled study evaluating an induction treatment strategy in which enfuvirtide was added to an oral, highly active antiretroviral therapy regimen in treatment-experienced patients: the INTENSE study

2008 ◽  
Vol 62 (6) ◽  
pp. 1374-1378 ◽  
Author(s):  
Bonaventura Clotet ◽  
Amedeo Capetti ◽  
Luis E. Soto-Ramirez ◽  
Jose M. Gatell ◽  
Lucy Rowell ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Treatment Strategy ◽  
Highly Active Antiretroviral Therapy ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Induction Treatment ◽  
Therapy Regimen ◽  
Randomized Controlled ◽  
Highly Active

Effect of intensive handwashing in the prevention of diarrhoeal illness among patients with AIDS: a randomized controlled study

2007 ◽  
Vol 56 (5) ◽  
pp. 659-663 ◽  
Author(s):  
David B. Huang ◽  
Jing Zhou
Keyword(s):  
Highly Active Antiretroviral Therapy ◽  
Shigella Flexneri ◽  
Intervention Group ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Control Group ◽  
Therapy Regimen ◽  
Randomized Controlled ◽  
Highly Active ◽  
Before And After

Patients with AIDS frequently develop diarrhoeal illness. In this randomized, controlled study, 260 patients were screened for those who had not had diarrhoea in the preceding 3 months and who had received a stable highly active antiretroviral therapy regimen for at least 6 weeks prior to the study enrolment. A total of 148 patients met the inclusion criteria and were enrolled: 75 patients were randomly assigned to an intensive handwashing intervention (i.e. handwashing after defecation, after cleaning infants who had defecated, before preparing food, before eating, and before and after sex) and 73 patients were randomly assigned to the control group. Patients in both groups were called weekly by telephone to determine compliance with handwashing and to determine the number of diarrhoeal episodes for the preceding week. Patients were observed for 1 year. Patients assigned to the intensive handwashing intervention group washed their hands more frequently compared with the control group (seven vs four times a day, respectively; P <0.05) and developed fewer episodes of diarrhoeal illness (1.24±0.9 vs 2.92±0.6 new episodes of diarrhoea, respectively; P <0.001) during the 1 year observation. The most common pathogens identified in both groups in patients who developed diarrhoeal illness were Giardia lamblia, Cryptosporidium, Entamoeba histolytica and Shigella flexneri. These data suggest that intensive handwashing reduces diarrhoeal illness in patients with AIDS.

Dietary nitrate improves skeletal muscle microvascular oxygenation in HIV-infected patients receiving highly active antiretroviral therapy: a randomised, double-blind, cross-over, placebo-controlled study

2020 ◽  
Vol 124 (12) ◽  
pp. 1277-1284 ◽  
Author(s):  
Elisa Barros-Santos ◽  
Gustavo Vieira de Oliveira ◽  
Mônica Volino-Souza ◽  
Thiago Silveira Alvares
Keyword(s):  
Antiretroviral Therapy ◽  
Oxygen Saturation ◽  
Highly Active Antiretroviral Therapy ◽  
Controlled Study ◽  
Exercise Recovery ◽  
Beetroot Juice ◽  
Handgrip Exercise ◽  
Double Blind ◽  
Muscle Oxygen ◽  
Highly Active

AbstractHIV-1 proteins and highly active antiretroviral therapy (HAART) have been associated with microvascular endothelial dysfunction. Although nitrate-rich beetroot juice (NR-BJ) consumption has been shown to improve endothelial function in clinical population, its effects in HIV-infected patients has not been addressed. We investigated the effect of a single dose of NR-BJ on muscle oxygen saturation parameters in response to a handgrip exercise in HIV-infected patients. Fifteen HIV-infected patients received NR-BJ or nitrate-depleted beetroot juice (ND-BJ) in a double-blind cross-over design. Near-IR spectroscopy was utilised to assess muscle oxygen saturation parameters during rhythmic handgrip exercise after NR-BJ or ND-BJ supplementation. A significant faster muscle oxygen desaturation rate during exercise (–7·97 (sd 5·00) v. –5·45 (3·94) %/s, P = 0·005) and muscle oxygen resaturation rate during exercise recovery (0·43 (0·24) v. 0·28 (0·24) %/s, P = 0·030) after NR-BJ ingestion was found. However, no significant difference in exercise time until fatigue was observed. Salivary nitrite and urinary nitrate concentration were analysed after NR-BJ or ND-BJ. A significant increase in salivary nitrite and urinary nitrate in NR-BJ was observed compared with ND-BJ (P < 0·05). Our findings suggest that NR-BJ consumption may acutely improve muscle oxygen saturation during exercise and exercise recovery in HIV-infected patients undergoing HAART and who are expected to present microvascular damage. Thus, future studies investigating the chronic effects of NR-BJ are warranted to delineate a better nutritional strategy based on nitrate-rich foods.

scholarly journals Coexistence of Kaposi sarcoma and Molluscum contagiosum on the same site in a HIV-AIDS patient: A very rare occurrence

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Kabir Abdullahi ◽  
Yahaya Mohammed ◽  
Saddiku A. Sahabi ◽  
Mahmood M. Dalhat
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Opportunistic Infections ◽  
Kaposi Sarcoma ◽  
Skin Lesions ◽  
Molluscum Contagiosum ◽  
University Teaching ◽  
Therapy Regimen ◽  
Highly Active ◽  
Hiv Aids

Introduction: There have been numerous reported opportunistic infections among HIV/AIDS patients. However, coexistence of Kaposi sarcoma and Molluscum contagiosum on the same site is a rare finding.Case presentation: A 37-year-old man poorly adherent to antiretroviral therapy presented with Molluscum contagiosum and Kaposi sarcoma occurring simultaneously on numerous skin lesions around mid-2017 at Usmanu Danfodiyo University Teaching Hospital, Sokoto State, Nigeria.Management and outcome: The patient was counselled and re-initiated on a second-line highly active antiretroviral therapy regimen. The patient’s lesions resolved three months later.Discussion: The case is presented to improve the index of suspicion among clinicians and pathologists on such rare occurrences.

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