scholarly journals Broad-spectrum in vitro antibacterial activities of clay minerals against antibiotic-susceptible and antibiotic-resistant bacterial pathogens

2007 ◽  
Vol 61 (2) ◽  
pp. 353-361 ◽  
Author(s):  
S. E. Haydel ◽  
C. M. Remenih ◽  
L. B. Williams
Keyword(s):  
Clay Minerals ◽  
Broad Spectrum ◽  
Bacterial Pathogens ◽  
Antibacterial Activities ◽  
Antibiotic Resistant

scholarly journals SCE-963, a New Broad-Spectrum Cephalosporin: In Vitro and In Vivo Antibacterial Activities

1978 ◽  
Vol 14 (4) ◽  
pp. 557-568 ◽  
Author(s):  
K. Tsuchiya ◽  
M. Kida ◽  
M. Kondo ◽  
H. Ono ◽  
M. Takeuchi ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Activities

scholarly journals In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens

2007 ◽  
Vol 51 (4) ◽  
pp. 1259-1267 ◽  
Author(s):  
Michael J. Pucci ◽  
Jijun Cheng ◽  
Steven D. Podos ◽  
Christy L. Thoma ◽  
Jane A. Thanassi ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Standard Dose ◽  
Antibacterial Activities ◽  
Gram Positive ◽  
Antibiotic Resistant ◽  
Gram Negative ◽  
Mrsa Strains ◽  
Time Kill

ABSTRACT The activities of several tricyclic heteroaryl isothiazolones (HITZs) against an assortment of gram-positive and gram-negative clinical isolates were assessed. These compounds target bacterial DNA replication and were found to possess broad-spectrum activities especially against gram-positive strains, including antibiotic-resistant staphylococci and streptococci. These included methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-nonsusceptible staphylococci, and quinolone-resistant strains. The HITZs were more active than the comparator antimicrobials in most cases. For gram-negative bacteria, the tested compounds were less active against members of the family Enterobacteriaceae but showed exceptional potencies against Haemophilus influenzae, Moraxella catarrhalis, and Neisseria spp. Good activity against several anaerobes, as well as Legionella pneumophila and Mycoplasma pneumoniae, was also observed. Excellent bactericidal activity against staphylococci was observed in time-kill assays, with an approximately 3-log drop in the numbers of CFU/ml occurring after 4 h of exposure to compound. Postantibiotic effects (PAEs) of 2.0 and 1.7 h for methicillin-susceptible S. aureus and MRSA strains, respectively, were observed, and these were similar to those seen with moxifloxacin at 10× MIC. In vivo efficacy was demonstrated in murine infections by using sepsis and thigh infection models. The 50% protective doses were ≤1 mg/kg of body weight against S. aureus in the sepsis model, while decreases in the numbers of CFU per thigh equal to or greater than those detected in animals treated with a standard dose of vancomycin were seen in the animals with thigh infections. Pharmacokinetic analyses of treated mice indicated exposures similar to those to ciprofloxacin at equivalent dose levels. These promising initial data suggest further study on the use of the HITZs as antibacterial agents.

scholarly journals In vitro studies on the antibacterial activities of YM-13115, a new broad-spectrum cephalosporin.

1985 ◽  
Vol 27 (4) ◽  
pp. 565-569 ◽  
Author(s):  
M Toda ◽  
N Arao ◽  
C Nohara ◽  
K Susaki ◽  
A Tachibana
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Activities ◽  
In Vitro Studies

scholarly journals Antioxidant and Antibacterial Properties of Extracts and Bioactive Compounds in Bryophytes

2021 ◽  
Vol 12 (1) ◽  
pp. 160
Author(s):  
Piergiorgio Cianciullo ◽  
Viviana Maresca ◽  
Sergio Sorbo ◽  
Adriana Basile
Keyword(s):  
Oxidative Stress ◽  
Antibacterial Properties ◽  
Natural Antioxidants ◽  
Antibacterial Activities ◽  
New Drugs ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Isolation And Characterization ◽  
State Of Research

Today global health problems such as increased risks of oxidative stress-related diseases and antibiotic resistance are issues of serious concern. Oxidative stress is considered to be the underlying cause of many contemporary pathological conditions such as neurological disorders, ischemia, cancer, etc. Antibiotic-resistant bacteria are a concerning issue in clinical practice, causing an increase in deadly infections. Bryophytes synthesize an outstanding number of secondary metabolites that have shown several potential therapeutic and nutraceutical applications. Research in the field has led to the isolation and characterization of several compounds (flavonoids, terpenoids, and bibenzyls). Some of these compounds have shown promising in vitro antibacterial activities and antioxidant potential comparable to known natural antioxidants such as ascorbic acid and α-tocopherol. However, the process of developing new drugs from naturally occurring molecules is often an impervious path. In this paper, the current state of research of bryophytic antioxidant and antibacterial applications is discussed.

Tailoring an Antibacterial Peptide of Human Lysosomal Cathepsin G to Enhance its Broad-Spectrum Action Against Antibiotic-Resistant Bacterial Pathogens

2002 ◽  
Vol 8 (9) ◽  
pp. 695-702 ◽  
Author(s):  
Willam Shafer ◽  
Samuel Katzif ◽  
Samera Bowers ◽  
Michael Fallon ◽  
M. Hubalek ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Pathogens ◽  
Antibacterial Peptide ◽  
Cathepsin G ◽  
Antibiotic Resistant

In vitro antibacterial activities of selected TB drugs in the presence of clay minerals against multidrug-resistant strain of Mycobacterium smegmatis

2020 ◽  
Vol 7 (1) ◽  
pp. 1742853
Author(s):  
Patrick K. Arthur ◽  
Vincent Amarh ◽  
Ethel J. S. Blessie ◽  
Rebecca Yeboah ◽  
Benjamin W. Kankpeyeng ◽  
...  
Keyword(s):  
Clay Minerals ◽  
Resistant Strain ◽  
Mycobacterium Smegmatis ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Multidrug Resistant Strain

scholarly journals Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities.

1981 ◽  
Vol 19 (1) ◽  
pp. 56-65 ◽  
Author(s):  
K Tsuchiya ◽  
M Kondo ◽  
M Kida ◽  
M Nakao ◽  
T Iwahi ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Activities

scholarly journals In vitro and in vivo antibacterial activities of FK037, a novel parenteral broad-spectrum cephalosporin.

1993 ◽  
Vol 37 (2) ◽  
pp. 301-307 ◽  
Author(s):  
K P Fu ◽  
B D Foleno ◽  
S C Lafredo ◽  
J M LoCoco ◽  
D M Isaacson
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Activities
Sign in / Sign up

Export Citation Format

Share Document