scholarly journals Randomized, double-blind study of the clinical efficacy of 3 days of azithromycin compared with co-amoxiclav for the treatment of acute otitis media

2003 ◽  
Vol 52 (3) ◽  
pp. 469-472 ◽  
Author(s):  
M. W. Dunne
Keyword(s):  
Otitis Media ◽  
Clinical Efficacy ◽  
Acute Otitis Media ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

Prevention and Therapy of Serous Otitis Media by Oral Decongestant: A Double-Blind Study in Pediatric Practice

PEDIATRICS ◽  
1978 ◽  
Vol 61 (5) ◽  
pp. 679-684 ◽  
Author(s):  
Ardis L. Olson ◽  
Suzanne W. Klein ◽  
Evan Charney ◽  
James B. MacWhinney ◽  
Thomas K. McInerny ◽  
...  
Keyword(s):  
Otitis Media ◽  
Clinical Evaluation ◽  
Acute Otitis Media ◽  
Blind Study ◽  
Double Blind Study ◽  
Pediatric Practice ◽  
Double Blind ◽  
Treatment Groups ◽  
Serous Otitis Media ◽  
Prevention And Therapy

We studied the efficacy of (1) preventing the development of serous otitis media (SOM) by using an oral decongestant in children with acute otitis media and (2) treating SOM with an oral decongestant. In a randomized double-blind study, 190 children were treated for acute otitis media with antibiotics and either pseudoephedrine hydrochloride (Sudafed) or placebo. They were evaluated two weeks later by tympanometry and (independently) by clinical evaluation and pneumotoscopy. There were no significant differences between the two groups, except that males developed SOM significantly more often than did females. Use of decongestant and placebo was continued in 78 patients with SOM for up to four more weeks. Again, there were no significant differences between the treatment groups except that patients with an allergic history did significantly worse using a decongestant. Overall there was no benefit from pseudoephedrine in either the prevention or treatment of SOM.

A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects with Osteoarthritis of Knee

2018 ◽  
Vol 21 (5) ◽  
pp. 511-520 ◽  
Author(s):  
Vasu Karlapudi ◽  
Anjaneya Venkata Vara Prasad Mungara ◽  
Krishanu Sengupta ◽  
Barbara A. Davis ◽  
Siba Prasad Raychaudhuri
Keyword(s):  
Clinical Efficacy ◽  
Human Subjects ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Osteoarthritis Of Knee ◽  
Herbal Formulation

Cyclacillin Versus Amoxicillin as Treatment for Acute Otitis Media

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 196-199
Author(s):  
Samuel E. McLinn ◽  
Steven Serlin
Keyword(s):  
Otitis Media ◽  
Clinical Success ◽  
Acute Otitis Media ◽  
Double Blind Study ◽  
Cure Rate ◽  
Double Blind ◽  
Resistant Strains ◽  
Low Incidence ◽  
Pediatric Outpatients ◽  
Upper Gastrointestinal

A double-blind study of 240 pediatric outpatients with acute otitis media demonstrated that cyclacillin administered three times a day for ten days, is as effective as and better tolerated than a similar regimen of amoxicillin. Clinical success was achieved in 96% of the children treated with each drug, and the bacteriologic cure rate was 98% in each treatment group. Only three of the 119 children (2.5%) treated with cyclacillin had drug-related diarrhea, in contrast to 17/121 children (14%) treated with amoxicllin (P <.01). This greater tolerance for cyclacillin may be due to its more effective and rapid absorption in the upper gastrointestinal tract. The results are discussed in terms of the low incidence of resistant strains of Haemophilus influenzae and the advantages of cyclacillin as the first-line treatment for acute otitis media.

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