The in vitro activity of Acyclovir and related compounds against cytomegalovirus infections

1981 ◽  
Vol 8 (1) ◽  
pp. 65-72 ◽  
Author(s):  
A. S. Tyms ◽  
E. M. Scamans ◽  
H. M. Naim
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Cytomegalovirus Infections ◽  
Related Compounds

Anticatalase Activity « in vitro » and « in vivo » of Cysteine, Tyrosine and Some Related Compounds, and its Significance for the Anticatalase Activity of Tumors.

1965 ◽  
Vol 51 (6) ◽  
pp. 433-439
Author(s):  
Giovanni Ceriotti ◽  
Luigi Spandrio ◽  
Angelo Agradi
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Similar Action ◽  
Related Compounds

Like cysteine and some of its derivatives, tyrosine inhibits liver catalase not only « in vitro » but also « in vivo ». Among the analogues of tyrosine tested, dihydroxyphenylalanine and dihydroxyphenethylamine possess « in vitro » the same activity as tyrosine; the activity of p-hydroxyphenylethanolamine is lower; phenylalanine is inactive. The «in vitro» activity seems to be directly correlated with the auto-oxidability of the various compounds. None of the analogues of tyrosine tested was active «in vivo». The depressing activity of cysteine and of tyrosine on liver catalase apparently has no relationship with the similar action of tumors.

ChemInform Abstract: Synthesis and Antiproliferative in vitro Activity of Natural Flavans and Related Compounds.

ChemInform ◽  
2008 ◽  
Vol 39 (13) ◽  
Author(s):  
Liang Zhang ◽  
Wei-Ge Zhang ◽  
En-Long Ma ◽  
Lan Wu ◽  
Kai Bao ◽  
...  
Keyword(s):  
Vitro Activity ◽  
In Vitro Activity ◽  
Related Compounds

scholarly journals Antiparasitic properties of homoallylamines and related compounds

2006 ◽  
Vol 51 (1) ◽  
Author(s):  
Alicia Gómez-Barrio ◽  
David Montero-Pereira ◽  
Juan Nogal-Ruiz ◽  
José Escario ◽  
Susana Muelas-Serrano ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Trichomonas Vaginalis ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Antiparasitic Activity ◽  
Murine Macrophages ◽  
Related Compounds

AbstractA study of some antiparasitic properties of several homoallylamines and related tetrahydroquinolines and quinolines, previously described, was carried out using in vitro activity assays against the epimastigote form of Trypanosoma cruzi and against Trichomonas vaginalis. Unspecific cytotoxicity against murine macrophages was also studied. Although the antichagasic and trichomonacidal activities are not comparable to those of the standard drugs, nifurtimox and metronidazole, some of the compounds exhibit an interesting specific antiparasitic activity.

scholarly journals Mode of Action of Sulfanilyl Fluoroquinolones

1998 ◽  
Vol 42 (6) ◽  
pp. 1495-1498 ◽  
Author(s):  
Fabiana Alovero ◽  
Marcelo Nieto ◽  
Maria Rosa Mazzieri ◽  
Rudolf Then ◽  
Ruben H. Manzo
Keyword(s):  
Mechanism Of Action ◽  
Bacterial Cell ◽  
Mode Of Action ◽  
Dna Supercoiling ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Aminobenzoic Acid ◽  
Kinetics Of ◽  
Related Compounds

ABSTRACT The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions withp-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed DNA supercoiling that is similar to the activity of other fluoroquinolones. Also, NSFQ-105 uptake was decreased by the presence of Mg2+and increased by a lower pH. These results indicate that NSFQs having only one ionizable group could exhibit more favorable kinetics of access to the bacterial cell than zwitterionic fluoroquinolones.

In Vitro Activity of Phytocannabinoids from High Potency Cannabis sativa

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
A Husni ◽  
S Ross ◽  
O Dale ◽  
C Gemelli ◽  
G Ma ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
High Potency
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