N-Formimidoyl thienamycin (MK0787): in-vitro antibacterial activity and susceptibility to beta-lactamases compared with that of cefotaxime, moxalactam and other beta-lactam antibiotics

1981 ◽  
Vol 7 (6) ◽  
pp. 607-617 ◽  
Author(s):  
David Hanslo ◽  
Anna King ◽  
Kevin Shannon ◽  
Christine Warren ◽  
Ian Phillips
Keyword(s):  
Antibacterial Activity ◽  
Beta Lactam ◽  
Beta Lactamases ◽  
Beta Lactam Antibiotics ◽  
In Vitro Antibacterial Activity

scholarly journals In vitro antibacterial activity of Sch 34343 and its stability to beta-lactamases and renal dehydropeptidase 1.

1985 ◽  
Vol 28 (5) ◽  
pp. 684-688 ◽  
Author(s):  
K Matsuda ◽  
K Sasaki ◽  
K Inoue ◽  
H Kondo ◽  
M Inoue ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Beta Lactamases ◽  
In Vitro Antibacterial Activity

scholarly journals Intraperitoneal treatment with antimicrobial peptide rescues mice from a pulmonaryFrancisellainfection

2019 ◽  
Author(s):  
Monique L. van Hoek ◽  
Akanksha Kaushal ◽  
Barney M. Bishop ◽  
Stephanie M. Barksdale
Keyword(s):  
Antibacterial Activity ◽  
Antimicrobial Peptides ◽  
Cyclic Peptide ◽  
Virulent Strain ◽  
Multi Drug Resistance ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
Peptide Derivatives ◽  
Low Cytotoxicity

AbstractOur long-term goal is to identify new antimicrobial peptides that might be effective against pneumonicFrancisellainfection in mice. Previously, our group searched the peptidome of the American alligator for novel cationic antimicrobial peptides and identified a naturally-occurring C-terminal fragment of apolipoprotein C-1, which we called Apo6. This peptide was found to have antibacterial activity against the ESKAPE pathogens, including those exhibiting multi-drug resistance. In this work, we tested Apo6 and synthetic derivatives for antibacterial activity againstFrancisella tularensisincluding the virulent strainF. tularensisSchuS4.Francisellais inherently highly resistant to the cyclic peptide polymyxin antibiotics and beta-lactam antibiotics. We found that our synthetic peptide derivatives (called GATR peptides), designed with increased hydrophobicity and charge, had generally strongerin vitroantimicrobial activity againstFrancisellathan the parent peptide Apo6. The GATR peptides had a greater effect on the bacterial membrane than the Apo6 peptide and were able to bindFrancisellaLPS, suggesting their mechanism of action againstFrancisella. Cytotoxicity experiments showed low cytotoxicity for most of the GATR peptides, and whole organism toxicity studies in the waxworm allowed us to down-select to two our lead peptides, GATR-3 and GATR-6. These peptides were tested in a murine pulmonary tularemia model. We found that the GATR-3 peptide rescued 50-60% of mice from lethal tularemia infection when administered systemically through the intraperitoneal route. This peptide is a candidate for further pre-clinical studies for a potential peptide-based approach to tularemia.

In Vitro Antibacterial activity of ethanolic extract of Myrsine africana against laboratory Strains of Pathogenic Organisms

2016 ◽  
Vol 5 (04) ◽  
pp. 4512
Author(s):  
Jackie K. Obey ◽  
Anthoney Swamy T* ◽  
Lasiti Timothy ◽  
Makani Rachel
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
E Coli ◽  
Zones Of Inhibition ◽  
In Vitro Antibacterial Activity ◽  
Myrsine Africana

The determination of the antibacterial activity (zone of inhibition) and minimum inhibitory concentration of medicinal plants a crucial step in drug development. In this study, the antibacterial activity and minimum inhibitory concentration of the ethanol extract of Myrsine africana were determined for Escherichia coli, Bacillus cereus, Staphylococcus epidermidis and Streptococcus pneumoniae. The zones of inhibition (mm±S.E) of 500mg/ml of M. africana ethanol extract were 22.00± 0.00 for E. coli,20.33 ±0.33 for B. cereus,25.00± 0.00 for S. epidermidis and 18. 17±0.17 for S. pneumoniae. The minimum inhibitory concentration(MIC) is the minimum dose required to inhibit growth a microorganism. Upon further double dilution of the 500mg/ml of M. africana extract, MIC was obtained for each organism. The MIC for E. coli, B. cereus, S. epidermidis and S. pneumoniae were 7.81mg/ml, 7.81mg/ml, 15.63mg/ml and 15.63mg/ml respectively. Crude extracts are considered active when they inhibit microorganisms with zones of inhibition of 8mm and above. Therefore, this study has shown that the ethanol extract of M. africana can control the growth of the four organisms tested.

Sign in / Sign up

Export Citation Format

Share Document