Single dose antibiotic prophylaxis of surgical wound sepsis: which route of administration is best? A controlled clinical trial of intra-incisional against intravenous cephaloridine

1981 ◽  
Vol 7 (3) ◽  
pp. 223-227 ◽  
Author(s):  
M. J. Greenall ◽  
J. E. Atkinson ◽  
Mary Evans ◽  
A. V. Pollock
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Antibiotic Prophylaxis ◽  
Route Of Administration ◽  
Controlled Clinical Trial ◽  
Surgical Wound ◽  
Wound Sepsis

scholarly journals Ceftriaxone versus ampicillin/cloxacillin as antibiotic prophylaxis in elective caesarean section

2004 ◽  
Vol 10 (3) ◽  
pp. 277-282
Author(s):  
E. T. S. Ahmed ◽  
O. A. Mirghani ◽  
A. S. Gerais ◽  
I. Adam
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Caesarean Section ◽  
Antibiotic Prophylaxis ◽  
Apgar Score ◽  
Statistical Difference ◽  
Elective Caesarean Section ◽  
Controlled Clinical Trial ◽  
Induction Of Anaesthesia ◽  
Febrile Morbidity

Wecarried out a prospective, r and omized, controlled clinical trial to evaluate the clinical efficacy of ceftriaxone and ampicillin/cloxacillin prophylaxis in decreasing the frequency of post-caesarean section infection-related morbidity. Two hundred patients randomly received either ceftriaxone [single dose] or ampicillin/cloxacillin [3 doses] intravenously at induction of anaesthesia. There was no statistical difference in incidence of endometritis [P = 0.34], wound infection [P = 0.44], or other febrile morbidity [P = 0.5]. Eleven babies had a low Apgar score [< 8] in the ceftriaxone group and 13 in the ampicillin/cloxacillin group [P = 0.82]. There were 2 perinatal deaths in each group. One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is easier to administer

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