Exposure to co-amoxiclav as a risk factor for co-amoxiclav-resistant Escherichia coli urinary tract infection

Acute myocarditis is a rare complication of Escherichia coli urinary tract infection and sepsis. We report the case of a previously healthy 55-year-old female who presented to our emergency department with diarrhea and hypotension. The basic metabolic panel results showed an increase in inflammatory markers and an acute kidney injury. Urine and blood cultures grew Escherichia coli. The patient subsequently developed sudden chest pain and shortness of breath, diffuse ST-segment elevation, and cardiac enzymes’ elevation. Coronary angiogram was normal, and transthoracic echocardiogram demonstrated normal ventricular functions. Cardiac magnetic resonance imaging was highly suspicious of myopericarditis. The patient made a full recovery after infection treatment with intravenous antibiotics, aspirin, and colchicine.

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Molecular typing of Escherichia coli strains isolated from urinary tract infection by ERIC-PCR

Gene Reports ◽

10.1016/j.genrep.2021.101058 ◽

2021 ◽

Vol 23 ◽

pp. 101058

Author(s):

Mahsa Movahedi ◽

Omid Zarei ◽

Maryam Hazhirkamal ◽

Pezhman Karami ◽

Leili Shokoohizadeh ◽

...

Keyword(s):

Escherichia Coli ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Molecular Typing

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Antimicrobial susceptibility patterns among Escherichia coli urinary isolates from community-onset health care-associated urinary tract infection

Journal of the Formosan Medical Association ◽

10.1016/j.jfma.2014.01.009 ◽

2014 ◽

Vol 113 (12) ◽

pp. 970-973 ◽

Cited By ~ 2

Author(s):

Ling-Fu Huang ◽

Yi-Chu Lo ◽

Lin-Hui Su ◽

Chin-Lu Chang

Keyword(s):

Escherichia Coli ◽

Health Care ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Antimicrobial Susceptibility ◽

Community Onset ◽

Urinary Isolates ◽

Susceptibility Patterns

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degS Is Necessary for Virulence and Is among Extraintestinal Escherichia coli Genes Induced in Murine Peritonitis

Infection and Immunity ◽

10.1128/iai.71.6.3088-3096.2003 ◽

2003 ◽

Vol 71 (6) ◽

pp. 3088-3096 ◽

Cited By ~ 40

Author(s):

Peter Redford ◽

Paula L. Roesch ◽

Rodney A. Welch

Keyword(s):

Escherichia Coli ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Luria Bertani ◽

Broth Culture ◽

Wild Type ◽

E Coli ◽

Virulence Attenuation

ABSTRACT Extraintestinal Escherichia coli strains cause meningitis, sepsis, urinary tract infection, and other infections outside the bowel. We examined here extraintestinal E. coli strain CFT073 by differential fluorescence induction. Pools of CFT073 clones carrying a CFT073 genomic fragment library in a promoterless gfp vector were inoculated intraperitoneally into mice; bacteria were recovered by lavage 6 h later and then subjected to fluorescence-activated cell sorting. Eleven promoters were found to be active in the mouse but not in Luria-Bertani (LB) broth culture. Three are linked to genes for enterobactin, aerobactin, and yersiniabactin. Three others are linked to the metabolic genes metA, gltB, and sucA, and another was linked to iha, a possible adhesin. Three lie before open reading frames of unknown function. One promoter is associated with degS, an inner membrane protease. Mutants of the in vivo-induced loci were tested in competition with the wild type in mouse peritonitis. Of the mutants tested, only CFT073 degS was found to be attenuated in peritoneal and in urinary tract infection, with virulence restored by complementation. CFT073 degS shows growth similar to that of the wild type at 37°C but is impaired at 43°C or in 3% ethanol LB broth at 37°C. Compared to the wild type, the mutant shows similar serum survival, motility, hemolysis, erythrocyte agglutination, and tolerance to oxidative stress. It also has the same lipopolysaccharide appearance on a silver-stained gel. The basis for the virulence attenuation is unclear, but because DegS is needed for σE activity, our findings implicate σE and its regulon in E. coli extraintestinal pathogenesis.

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