scholarly journals Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections

2001 ◽  
Vol 48 (5) ◽  
pp. 677-689 ◽  
Author(s):  
J. P.A. Ioannidis
Keyword(s):  
Respiratory Tract Infections ◽  
Meta Analysis ◽  
Upper Respiratory Tract Infections ◽  
Controlled Trials ◽  
Upper Respiratory Tract ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Randomized Controlled ◽  
Upper Respiratory ◽  
Tract Infections

scholarly journals Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Laodong Li ◽  
KangKang Hong ◽  
Qixiang Sun ◽  
Huan Xiao ◽  
Lejin Lai ◽  
...  
Keyword(s):  
Placebo Group ◽  
Respiratory Tract ◽  
Rate Ratio ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Controlled Trials ◽  
Upper Respiratory Tract ◽  
Randomized Controlled ◽  
Upper Respiratory ◽  
Tract Infections

Background. Upper respiratory tract infections (URTIs) are common and burdensome infectious illness. Several trials have reported that probiotics can prevent URTIs in adults. Objectives. To evaluate the efficacy and safety of probiotics in the prevention of URTIs in adults. Methods. PubMed, Web of Science, Embase, and Cochrane Library were searched for reports published from database inception to May 14, 2020. Randomized controlled trials (RCTs) comparing probiotics with placebo for the prevention of URTIs in adults were included. Results. Six RCTs with 1551 participants were included. Compared with the placebo group, the probiotics intervention group significantly reduced the incidence of URTI episodes (RR: 0.77; 95% CI: 0.68 to 0.87; P < 0.0001 ; I2 = 26%), the episode rate of URTIs (rate ratio: 0.72; 95% CI: 0.60 to 0.86; P = 0.0002 ; I2 = 99%), and the mean duration of one episode of URTI (MD: −2.66; 95% CI: −4.79 to −0.54; P = 0.01 ; I2 = 80%). The adverse events of probiotics were mainly mild gastrointestinal symptoms. There were no significant differences in occurrence rate of adverse effects between probiotics intervention and placebo group (rate ratio: 1.01; 95% CI: 0.80 to 1.26; P = 0.96 ; I2 = 99%). Conclusion. Low-quality evidence provides support that probiotics have potential efficacy for preventing URTI episodes in adults. More trials are required to confirm this conclusion.

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