scholarly journals Fluoroquinolones as treatment for patients with lower respiratory tract infections caused by Streptococcus pneumoniae.

1998 ◽  
Vol 42 (3) ◽  
pp. 398-399 ◽  
Author(s):  
S. G. Amyes ◽  
C. J. Thomson
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

Etiological Trends and Antibiotic Susceptibility of Bacterial Strains Causing Respiratory Tract Infections

2020 ◽  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Bacterial Isolates ◽  
Lower Respiratory Tract Infections ◽  
Streptococcus Pneumonia ◽  
Tract Infections

Background: Lower respiratory tract infections (LTRIs) are emerging as the most common infectious diseases of humans. Antibiotic resistance has increased in all the major pathogens therefore, this project engrossed on defining the current drift of bacterial etiologies of respiratory tract infections among the patients and their antimicrobial susceptibility pattern. Methods: This cross-sectional study with non-probability consecutive sampling was conducted in the microbiology laboratory of Ziauddin Hospital. Bacterial isolates (163) were recuperated from respiratory sputum specimens obtained from patients with lower respiratory tract infections. The pathogens collected for study were Streptococcus pneumonia, Haemophilus influenzae, and Moraxella catarrhalis. Frequencies and percentages were computed for categorical variables like microorganism, gender, age, duration of lower respiratory tract infections, etc. Mean and standard deviation were calculated for quantitative variables like age and infection duration. Furthermore, duration of disease was stratified by post stratification Chi Square with p value ≤ 0.05 was considered significant. Results: Most commonly isolated pathogen is Moraxella catarrhalis 72.39% followed by Haemophilus influenza 14.72% and Streptococcus pneumonia 12.88%. For Streptococcus pneumoniae 47% sensitivity showed to Ampicillin, 52% Penicillin, 61.9% Erythromycin and 57% to Ceftriaxone. For Haemophilus influenzae 100%, sensitivity showed to Ceftriaxone, 100% Amoxicillin and 62.5% Co-trimoxazole. Similarly, for Moraxella catarrhalis 54% sensitivity was showed to Erythromycin, 100% Ceftriaxone and 27% with Levofloxacin. Conclusion: Moraxella catarrhalis, Haemophilus influenzae and Streptococcus pneumoniae were the most common bacterial isolates recovered from LTRIs. We found M. catarrhalis resistant rate was elevated for Levofloxacin, Streptococcus pneumonia for Co-trimoxazole and Haemophilus influenzae to all β-lactams. Keywords: Respiratory Tract Infection; Haemophilus influenzae; Moraxella catarrhalis; Streptococcus pneumonia.

scholarly journals Bacterial Aetiologies of Lower Respiratory Tract Infections among Adults in Yaoundé, Cameroon

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Serges Tchatchouang ◽  
Ariane Nzouankeu ◽  
Sebastien Kenmoe ◽  
Laure Ngando ◽  
Veronique Penlap ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Rt Pcr ◽  
Lower Respiratory Tract Infections ◽  
Healthcare Settings ◽  
Few Data ◽  
Tract Infections

Lower respiratory tract infections (LRTIs) remain a challenge in African healthcare settings and only few data are available on their aetiology in Cameroon. The purpose of this study was to access the bacterial cause of LRTIs in patients in Cameroon by two methods.Methods. Participants with LRTIs were enrolled in the referral centre for respiratory diseases in Yaoundé city and its surroundings. To detect bacteria, specimens were tested by conventional bacterial culture and a commercial reverse-transcriptase real-time polymerase chain reaction (RT-PCR) assay. One hundred forty-one adult patients with LRTIs were enrolled in the study. Among the participants, 46.8% were positive for at least one bacterium.Streptococcus pneumoniaeandHaemophilus influenzaewere the most detected bacteria with 14.2% (20/141) followed byKlebsiella pneumoniae, 9.2% (13/141),Staphylococcus aureus, 7.1% (10/141), andMoraxella catarrhalis, 4.3% (6/141). Bacterial coinfection accounted for 23% (14/61) withHaemophilus influenzaebeing implicated in 19.7% (12/61). The diagnostic performance of RT-PCR for bacteria detection (43.3%) was significantly different from that of culture (17.7%) (p< 0.001). OnlyStreptococcus pneumoniaedetection was associated with empyema by RT-PCR (p<0.001). These findings enhance understanding of bacterial aetiologies in order to improve respiratory infection management and treatment. It also highlights the need to implement molecular tools as part of the diagnosis of LRTIs.

scholarly journals In VitroActivity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States

2016 ◽  
Vol 60 (7) ◽  
pp. 4407-4411 ◽  
Author(s):  
Rodrigo E. Mendes ◽  
David J. Farrell ◽  
Robert K. Flamm ◽  
George H. Talbot ◽  
Zrinka Ivezic-Schoenfeld ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
The United States ◽  
Multidrug Resistant ◽  
Lower Respiratory Tract Infections ◽  
Content Type ◽  
Common Serotypes ◽  
Tract Infections

ABSTRACTLefamulin was evaluated against variousStreptococcus pneumoniaeserotypes that were collected from adults with lower respiratory tract infections. Lefamulin exhibited MIC50and MIC90values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n= 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin. These data support the clinical development of lefamulin for the treatment of community-acquired respiratory tract infections.

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