The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment

1993 ◽  
Vol 32 (6) ◽  
pp. 867-875 ◽  
Author(s):  
Frederick A. Sirgel ◽  
Frederik J. H. Botha ◽  
Donald P. Parkin ◽  
Bernard W. Van De Wal ◽  
Peter R. Donald ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
New Method

scholarly journals Whole Blood Bactericidal Activity during Treatment of Pulmonary Tuberculosis

2003 ◽  
Vol 187 (2) ◽  
pp. 270-278 ◽  
Author(s):  
Robert S. Wallis ◽  
Solange A. Vinhas ◽  
John L. Johnson ◽  
Fabíola C. Ribeiro ◽  
Moisés Palaci ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
Whole Blood

scholarly journals The Bactericidal Activity of Moxifloxacin in Patients with Pulmonary Tuberculosis

2003 ◽  
Vol 168 (11) ◽  
pp. 1342-1345 ◽  
Author(s):  
Roly D. Gosling ◽  
Leonard O. Uiso ◽  
Noel E. Sam ◽  
Emily Bongard ◽  
Esther G. Kanduma ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity

A new method for producing highly concentrated non-aqueous dispersions of silver nanoparticles and the evaluation of their bactericidal activity

2014 ◽  
Vol 16 (11) ◽  
Author(s):  
Roselaine da S. Oliveira ◽  
Marcos A. Bizeto ◽  
Ana M. A. Liberatore ◽  
Ivan H. J. Koh ◽  
Fernanda F. Camilo
Keyword(s):  
Silver Nanoparticles ◽  
Bactericidal Activity ◽  
New Method ◽  
Aqueous Dispersions

scholarly journals Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis

2008 ◽  
Vol 52 (8) ◽  
pp. 2831-2835 ◽  
Author(s):  
R. Rustomjee ◽  
A. H. Diacon ◽  
J. Allen ◽  
A. Venter ◽  
C. Reddy ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
Dose Range ◽  
Study Drug ◽  
First Line ◽  
Serious Adverse Events ◽  
Once Daily ◽  
Smear Positive Pulmonary Tuberculosis

ABSTRACT Tibotec Medicinal Compound 207 (TMC207) is a novel diarylquinoline with a unique mode of action that targets mycobacterial ATP synthase. TMC207 exhibits high in vitro activity against mycobacterial strains either susceptible or resistant to all first-line and many second-line drugs, including fluoroquinolones, and has shown exceptional in vivo activity against several mycobacterial species in different animal models. In this early bactericidal activity study, 75 treatment-naïve patients with smear-positive pulmonary tuberculosis were randomized to once-daily oral TMC207 (25 mg, 100 mg, or 400 mg), 600 mg rifampin (RIF), or 300 mg isoniazid (INH) for 7 days. Sixteen-hour overnight sputum collected at baseline and on each treatment day was plated in serial dilutions on selective agar plates. The bactericidal activity was expressed as the log10 decrease in CFU/ml sputum/day. Pharmacokinetic sampling was performed on day 7 of TMC207 administration up to 24 h postdose. The decreases in log10 CFU counts (± standard deviation) from baseline to day 7 were 0.04 ± 0.46 for 25 mg TMC207 (n = 14), 0.26 ± 0.64 for 100 mg TMC207 (n = 14), 0.77 ± 0.58 for 400 mg TMC207 (n = 14), 1.88 ± 0.74 for INH (n = 11), and 1.70 ± 0.71 for RIF (n = 14). Significant bactericidal activity of 400 mg TMC207 was observed from day 4 onward and was similar in magnitude to those of INH and RIF over the same period. The pharmacokinetics of TMC207 were linear across the dose range. In summary, TMC207 demonstrated bactericidal activity with a delayed onset and was well tolerated, and no study drug-related serious adverse events occurred.

scholarly journals Randomized Dose-Ranging Study of the 14-Day Early Bactericidal Activity of Bedaquiline (TMC207) in Patients with Sputum Microscopy Smear-Positive Pulmonary Tuberculosis

2013 ◽  
Vol 57 (5) ◽  
pp. 2199-2203 ◽  
Author(s):  
Andreas H. Diacon ◽  
Rodney Dawson ◽  
Florian Von Groote-Bidlingmaier ◽  
Gregory Symons ◽  
Amour Venter ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
Linear Trend ◽  
Sputum Smear ◽  
Sputum Microscopy ◽  
Blinded Study ◽  
Smear Positive Pulmonary Tuberculosis ◽  
Dose Ranging ◽  
Safety Considerations ◽  
Double Blinded

ABSTRACTBedaquiline is a new antituberculosis agent targeting ATP synthase. This randomized, double-blinded study enrolling 68 sputum smear-positive pulmonary tuberculosis patients evaluated the 14-day early bactericidal activity of daily doses of 100 mg, 200 mg, 300 mg, and 400 mg bedaquiline, preceded by loading doses of 200 mg, 400 mg, 500 mg, and 700 mg, respectively, on the first treatment day and 100 mg, 300 mg, 400 mg, and 500 mg on the second treatment day. All groups showed activity with a mean (standard deviation) daily fall in log10CFU over 14 days of 0.040 (0.068), 0.056 (0.051), 0.077 (0.064), and 0.104 (0.077) in the 100-mg, 200-mg, 300-mg, and 400-mg groups, respectively. The linear trend for dose was significant (P= 0.001), and activity in the 400-mg dose group was greater than that in the 100-mg group (P= 0.014). All of the bedaquiline groups showed significant bactericidal activity that was continued to the end of the 14-day evaluation period. The finding of a linear trend for dose suggests that the highest dose compatible with safety considerations should be taken forward to longer-term clinical studies.

scholarly journals Early bactericidal activity of a moxifloxacin and isoniazid combination in smear-positive pulmonary tuberculosis

2005 ◽  
Vol 56 (6) ◽  
pp. 1169-1171 ◽  
Author(s):  
Stephen H. Gillespie ◽  
Roly D. Gosling ◽  
Leonard Uiso ◽  
Noel E. Sam ◽  
Esther G. Kanduma ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
Smear Positive Pulmonary Tuberculosis

scholarly journals Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears

2007 ◽  
Vol 51 (8) ◽  
pp. 2994-2996 ◽  
Author(s):  
A. H. Diacon ◽  
R. F. Patientia ◽  
A. Venter ◽  
P. D. van Helden ◽  
P. J. Smith ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Bactericidal Activity ◽  
Standard Dose ◽  
Tuberculosis Treatment ◽  
High Dose

ABSTRACT We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.

Sign in / Sign up

Export Citation Format

Share Document