Phenoxymethyl-penicillin vs co-amoxyclav in acute recurrent tonsillitis

M. J. SHEPPARD; T. W. J. KELLY

doi:10.1093/jac/25.3.474

Phenoxymethyl-penicillin vs co-amoxyclav in acute recurrent tonsillitis

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/25.3.474 ◽

1990 ◽

Vol 25 (3) ◽

pp. 474-474 ◽

Cited By ~ 11

Author(s):

M. J. SHEPPARD ◽

T. W. J. KELLY

Keyword(s):

Recurrent Tonsillitis ◽

Phenoxymethyl Penicillin

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Aminopenicillin-induced exanthema allows treatment with certain cephalosporins or phenoxymethyl penicillin

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkm146 ◽

2007 ◽

Vol 60 (1) ◽

pp. 107-111 ◽

Cited By ~ 40

Author(s):

Jiri Trcka ◽

Cornelia S. Seitz ◽

Eva-B. Bröcker ◽

Gerd E. Gross ◽

Axel Trautmann

Keyword(s):

Phenoxymethyl Penicillin

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A Trimer of Phenoxymethyl Penicillin Sulphone: Synthesis of a New .BETA.-Lactam Podand.

The Journal of Antibiotics ◽

10.7164/antibiotics.55.524 ◽

2002 ◽

Vol 55 (5) ◽

pp. 524-527 ◽

Cited By ~ 2

Author(s):

ATTILA AGÓCS ◽

PÁL HERCZEGH ◽

FERENC SZTARICSKAI ◽

ZSUZSA GÁL ◽

FERENC HERNÁDI

Keyword(s):

Beta Lactam ◽

Phenoxymethyl Penicillin

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In Vivo Sensitivity Test in Otitis Media: Efficacy of Antibiotics

PEDIATRICS ◽

10.1542/peds.75.1.8 ◽

1985 ◽

Vol 75 (1) ◽

pp. 8-13 ◽

Cited By ~ 1

Author(s):

Virgil M. Howie ◽

Ruth Dillard ◽

Barbara Lawrence

Keyword(s):

Otitis Media ◽

Middle Ear ◽

Penicillin G ◽

Treatment Results ◽

Double Blind ◽

Phenoxymethyl Penicillin ◽

Procaine Penicillin ◽

The Poor

During a 10-year period, antibiotics were assigned in random, double-blind fashion in six combinations to treat 948 episodes of otitis media in children. Exudate from the middle ear of all patients was cultured before treatment. Three follow-up visits were conducted; the first follow-up visit was three to five days after the start of therapy, and the second and third visits were 14 and 31 days after onset of treatment. Exudates were recultured for 75% of the patients on the first follow-up visit. Comparison of treatment results showed that triple sulfonamide combined with either phenoxymethyl penicillin, or benzathine and procaine penicillin G given intramuscularly (IM) was as effective as was ampicillin or amoxicillin. Phenoxymethyl penicillin and cyclacillin alone were usually effective against pneumococci but relatively ineffective against Haemophilus influenzae. Cefaclor and trimethoprim-sulfamethoxazole produced unsatisfactory results in about half the cases caused by pneumococci or H influenzae. Although production of β-lactamase by some otitis-causing Haemophilus and Staphylococcus species may explain the ineffectiveness of some treatments, the percentage of organisms positive for β-lactamase was too small to be responsible for the poor results with certain drugs.

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THERAPEUTIC PRINCIPLES FOR STREPTOCOCCUS VIRIDANS INFECTIONS: RECURRENT BACTERIAL ENDOCARDITIS IN A CHILD WITH CONGENITAL HEART DISEASE

PEDIATRICS ◽

10.1542/peds.35.4.704 ◽

1965 ◽

Vol 35 (4) ◽

pp. 704-708

Author(s):

Welton M. Gersony ◽

Alexander S. Nadas

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Bacterial Endocarditis ◽

Intravenous Therapy ◽

Phenoxymethyl Penicillin ◽

Serum Bactericidal Activity ◽

Therapeutic Principles ◽

Penicillin Therapy ◽

Principles Of Treatment

A case of recurrent bacterial endocarditis due to a relatively resistant alpha streptococcus is reviewed. The following general principles of treatment are recommended: 1. Intravenous penicillin therapy should be instituted in all instances. 2. Should serum bactericidal levels indicate the organism to be extremely sensitive (< 0.1 units/ml) oral phenoxymethyl penicillin (Penicillin-V) may be substituted after 3 weeks. 3. In cases infected with organisms sensitive to greater than 0.1 units/ml, intravenous therapy should be continued for 6 weeks and streptomycin added for 2 weeks. 4. When facilities for studying penicillin sensitivity and serum bactericidal activity are not available, the intravenous penicillin-streptomycin regime is recommended.

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