scholarly journals Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy

2006 ◽  
Vol 18 (7) ◽  
pp. 1067-1077 ◽  
Author(s):  
A. F. M. Maree
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes ◽  
Specific Therapy

The Role of CD4 and CD8 T cells in the Development of Autoimmune Diabetes

1999 ◽  
Vol 13 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Samuel M. Dilts ◽  
Nanette Solvason ◽  
Kevin J. Lafferty
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes

Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

Nature ◽  
10.1038/18692 ◽  
1999 ◽  
Vol 398 (6725) ◽  
pp. 341-344 ◽  
Author(s):  
Christian Kurts ◽  
Francis R. Carbone ◽  
Matthew F. Krummel ◽  
Karl M. Koch ◽  
Jacques F. A. P. Miller ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes

scholarly journals Cytocidal macrophages in symbiosis with CD4 and CD8 T cells cause acute diabetes following checkpoint blockade of PD-1 in NOD mice

2020 ◽  
Vol 117 (49) ◽  
pp. 31319-31330
Author(s):  
Hao Hu ◽  
Pavel N. Zakharov ◽  
Orion J. Peterson ◽  
Emil R. Unanue
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes ◽  
Critical Role ◽  
Nod Mice ◽  
Checkpoint Blockade ◽  
Cellular Interactions ◽  
Activated T Cells ◽  
Acute Diabetes ◽  
Ifn Γ

Autoimmune diabetes is one of the complications resulting from checkpoint blockade immunotherapy in cancer patients, yet the underlying mechanisms for such an adverse effect are not well understood. Leveraging the diabetes-susceptible nonobese diabetic (NOD) mouse model, we phenocopy the diabetes progression induced by programmed death 1 (PD-1)/PD-L1 blockade and identify a cascade of highly interdependent cellular interactions involving diabetogenic CD4 and CD8 T cells and macrophages. We demonstrate that exhausted CD8 T cells are the major cells that respond to PD-1 blockade producing high levels of IFN-γ. Most importantly, the activated T cells lead to the recruitment of monocyte-derived macrophages that become highly activated when responding to IFN-γ. These macrophages acquire cytocidal activity against β-cells via nitric oxide and induce autoimmune diabetes. Collectively, the data in this study reveal a critical role of macrophages in the PD-1 blockade-induced diabetogenesis, providing new insights for the understanding of checkpoint blockade immunotherapy in cancer and infectious diseases.

scholarly journals Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8+T cells

2013 ◽  
Vol 173 (2) ◽  
pp. 184-194 ◽  
Author(s):  
X.-L. Chen ◽  
D. Bobbala ◽  
G. M. Rodriguez ◽  
M. Mayhue ◽  
Y.-G. Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Interleukin 21

scholarly journals Erratum: correction: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

Nature ◽  
2000 ◽  
Vol 407 (6802) ◽  
pp. 413-413 ◽  
Author(s):  
Christian Kurts ◽  
Francis R. Carbone ◽  
Matthew F. Krummel ◽  
Karl M. Koch ◽  
Jacques F. A. P. Miller ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Autoimmune Diabetes
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