Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses

1995 ◽  
Vol 7 (4) ◽  
pp. 679-688 ◽  
Author(s):  
Smita Nair ◽  
Antoinette M. J. Buiting ◽  
Richard J. D. Rouse ◽  
Nico Van Rooijen ◽  
Leaf Huang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses

scholarly journals Critical Role of TLR7 Signaling in the Priming of Cross-Protective Cytotoxic T Lymphocyte Responses by a Whole Inactivated Influenza Virus Vaccine

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63163 ◽  
Author(s):  
Natalija Budimir ◽  
Aalzen de Haan ◽  
Tjarko Meijerhof ◽  
Simke Waijer ◽  
Louis Boon ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Lymphocyte ◽  
Virus Vaccine ◽  
Cytotoxic T Lymphocyte ◽  
Critical Role ◽  
Influenza Virus Vaccine ◽  
Lymphocyte Responses

Dendritic Cells and Antigen Presentation in the Regulation of Cytotoxic T Lymphocyte Responses against Viruses and Transplantation Antigens

1988 ◽  
Vol 532 (1 Cytotoxic T C) ◽  
pp. 280-291 ◽  
Author(s):  
CORNELIS J. M. MELIEF ◽  
CLAIRE J. P. BOOG ◽  
WIES L. E. VASMEL ◽  
JOLANDE BOES ◽  
ARIE C. VOORDOUW ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Antigen Presentation ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses ◽  
Transplantation Antigens

Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients

Blood ◽  
2005 ◽  
Vol 106 (6) ◽  
pp. 2186-2188 ◽  
Author(s):  
Cyril Fauriat ◽  
Alessandro Moretta ◽  
Daniel Olive ◽  
Régis T. Costello
Keyword(s):  
Acute Myeloid Leukemia ◽  
Dendritic Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
T Lymphocyte ◽  
Myeloid Leukemia ◽  
Ex Vivo ◽  
Lymphocyte Responses ◽  
Acute Myeloid

Abstract At the frontier between innate and adaptive immunity, dendritic cells (DCs) secrete numerous cytokines and express costimulatory molecules that initiate or enhance natural killer (NK) and T-lymphocyte responses. NK cells also regulate DC physiology by killing immature DCs (iDCs), thus limiting inflammation and inappropriate T-lymphocyte tolerization. In a previous study, we have reported that NK cells from acute myeloid leukemia patients (AML-NK cells) have deficient natural cytotoxicity receptor (NCR) expression. Herein, we analyzed the consequences of such a defect regarding the regulatory role of AML-NK cells in DC physiology. We show that NK cells display poor cytolytic capacities against DCs derived from healthy donor monocytes or derived from autologous leukemic blasts. These data point to a novel defect in the regulation of adaptive immune responses initiated by DCs in AML patients. This may lead to specific T-lymphocyte tolerization by spontaneous or ex vivo expanded iDCs expressing leukemia-derived antigens. (Blood. 2005;106: 2186-2188)

scholarly journals Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity

Immunology ◽  
2007 ◽  
Vol 120 (1) ◽  
Author(s):  
Siguo Hao ◽  
Ou Bai ◽  
Fang Li ◽  
Jinying Yuan ◽  
Suzanne Laferte ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses
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