scholarly journals Virus-Specific Antibody Secreting Cell, Memory B-cell, and Sero-Antibody Responses in the Human Influenza Challenge Model

2014 ◽  
Vol 209 (9) ◽  
pp. 1354-1361 ◽  
Author(s):  
Kuan-Ying Arthur Huang ◽  
Chris Ka-Fai Li ◽  
Elizabeth Clutterbuck ◽  
Cecilia Chui ◽  
Tom Wilkinson ◽  
...  
Keyword(s):  
B Cell ◽  
Specific Antibody ◽  
Antibody Responses ◽  
Human Influenza ◽  
Secreting Cell ◽  
Cell Memory ◽  
Memory B Cell ◽  
Antibody Secreting Cell ◽  
Virus Specific Antibody

scholarly journals A Potent Virus-Specific Antibody-Secreting Cell Response to Acute Enterovirus 71 Infection in Children

2015 ◽  
Vol 212 (5) ◽  
pp. 808-817 ◽  
Author(s):  
Kuan-Ying Arthur Huang ◽  
Jainn-Jim Lin ◽  
Cheng-Hsun Chiu ◽  
Shuan Yang ◽  
Kuo-Chien Tsao ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Cell Response ◽  
Enterovirus 71 ◽  
Secreting Cell ◽  
Antibody Secreting Cell ◽  
Virus Specific Antibody ◽  
Enterovirus 71 Infection

scholarly journals Expansion of SARS-CoV-2-specific Antibody-secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients

2020 ◽  
Author(s):  
Renata Varnaitė ◽  
Marina García ◽  
Hedvig Glans ◽  
Kimia T. Maleki ◽  
John Tyler Sandberg ◽  
...  
Keyword(s):  
B Cell ◽  
Specific Antibody ◽  
Neutralizing Antibodies ◽  
Cell Activation ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
B Cell Activation ◽  
Immunological Parameters ◽  
Antibody Secreting Cell ◽  
Antibody Levels

AbstractCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in late 2019 and has since become a global pandemic. Pathogen-specific antibodies are typically a major predictor of protective immunity, yet B cell and antibody responses during COVID-19 are not fully understood. Here, we analyzed antibody-secreting cell (ASC) and antibody responses in twenty hospitalized COVID-19 patients. The patients exhibited typical symptoms of COVID-19, and presented with reduced lymphocyte numbers and increased T cell and B cell activation. Importantly, we detected an expansion of SARS-CoV-2 nucleocapsid protein-specific ASCs in all twenty COVID-19 patients using a multicolor FluoroSpot assay. Out of the 20 patients, 16 had developed SARS-CoV-2-neutralizing antibodies by the time of inclusion in the study. SARS-CoV-2-specific IgA, IgG and IgM antibody levels positively correlated with SARS-CoV-2-neutralizing antibody titers, suggesting that SARS-CoV-2-specific antibody levels may reflect the titers of neutralizing antibodies in COVID-19 patients during the acute phase of infection. Lastly, we showed that interleukin 6 (IL-6) and C-reactive protein (CRP) concentrations were higher in serum of patients who were hospitalized for longer, supporting the recent observations that IL-6 and CRP could be used to predict COVID-19 severity. Altogether, this study constitutes a detailed description of clinical and immunological parameters in twenty COVID-19 patients, with a focus on B cell and antibody responses, and provides tools to study immune responses to SARS-CoV-2 infection and vaccination.

scholarly journals Modeling the Dynamics and Migratory Pathways of Virus-Specific Antibody-Secreting Cell Populations in Primary Influenza Infection

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104781 ◽  
Author(s):  
Hongyu Miao ◽  
Mark Y. Sangster ◽  
Alexandra M. Livingstone ◽  
Shannon P. Hilchey ◽  
Le Zhang ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Influenza Infection ◽  
Cell Populations ◽  
Secreting Cell ◽  
Antibody Secreting Cell ◽  
Virus Specific Antibody

scholarly journals Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19

1998 ◽  
Vol 188 (1) ◽  
pp. 145-155 ◽  
Author(s):  
Thomas Fehr ◽  
Robert C. Rickert ◽  
Bernhard Odermatt ◽  
Jürgen Roes ◽  
Klaus Rajewsky ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Cell Activation ◽  
Antibody Responses ◽  
B Cell Activation ◽  
Protein Antigens ◽  
Cell Memory ◽  
B Cell Memory

Coligation of CD19, a molecule expressed during all stages of B cell development except plasmacytes, lowers the threshold for B cell activation with anti-IgM by a factor of 100. The cytoplasmic tail of CD19 contains nine tyrosine residues as possible phosphorylation sites and is postulated to function as the signal transducing element for complement receptor (CR)2. Generation and analysis of CD19 gene–targeted mice revealed that T cell–dependent (TD) antibody responses to proteinaceous antigens were impaired, whereas those to T cell–independent (TI) type 2 antigens were normal or even augmented. These results are compatible with earlier complement depletion studies and the postulated function of CD19. To analyze the role of CD19 in antiviral antibody responses, we immunized CD19−/− mice with viral antigens of TI-1, TI-2, and TD type. The effect of CD19 on TI responses was more dependent on antigen dose and replicative capacity than on antigen type. CR blocking experiments confirmed the role of CD19 as B cell signal transducer for complement. In contrast to immunization with protein antigens, infection of CD19−/− mice with replicating virus led to generation of specific germinal centers, which persisted for >100 d, whereas maintenance of memory antibody titers as well as circulating memory B cells was fully dependent on CD19. Thus, our study confirms a costimulatory role of CD19 on B cells under limiting antigen conditions and indicates an important role for B cell memory.

Viremia controls Env-specific antibody-secreting cell responses in SIV-infected macaques pre- and post-ART

AIDS ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Eduardo L.V. Silveira ◽  
Jung Joo Hong ◽  
Praveen K. Amancha ◽  
Kenneth A. Rogers ◽  
Aftab A. Ansari ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Secreting Cell ◽  
Antibody Secreting Cell ◽  
Cell Responses

scholarly journals Delayed virus‐specific antibody responses associate with COVID‐19 mortality

Allergy ◽  
2020 ◽  
Author(s):  
Feng Wang ◽  
Yin Yao ◽  
Hongyan Hou ◽  
Shiji Wu ◽  
Cuilian Guo ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Antibody Responses ◽  
Virus Specific Antibody

scholarly journals EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production

2017 ◽  
Vol 200 (3) ◽  
pp. 1039-1052 ◽  
Author(s):  
Muyao Guo ◽  
Madeline J. Price ◽  
Dillon G. Patterson ◽  
Benjamin G. Barwick ◽  
Robert R. Haines ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Production ◽  
Cell Metabolism ◽  
Transcriptional Program ◽  
Secreting Cell ◽  
Antibody Secreting Cell
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