scholarly journals Interleukin 22 Inhibits Intracellular Growth of Mycobacterium tuberculosis by Enhancing Calgranulin A Expression

2013 ◽  
Vol 209 (4) ◽  
pp. 578-587 ◽  
Author(s):  
Rohan Dhiman ◽  
Sambasivan Venkatasubramanian ◽  
Padmaja Paidipally ◽  
Peter F. Barnes ◽  
Amy Tvinnereim ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Intracellular Growth ◽  
Interleukin 22 ◽  
Calgranulin A

scholarly journals A Hydrolase of Trehalose Dimycolate Induces Nutrient Influx and Stress Sensitivity to Balance Intracellular Growth of Mycobacterium tuberculosis

2014 ◽  
Vol 15 (2) ◽  
pp. 153-163 ◽  
Author(s):  
Yong Yang ◽  
Kathleen Kulka ◽  
Ronald C. Montelaro ◽  
Todd A. Reinhart ◽  
James Sissons ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Stress Sensitivity ◽  
Intracellular Growth ◽  
Trehalose Dimycolate ◽  
Nutrient Influx

scholarly journals β-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages

2011 ◽  
Vol 51 (4) ◽  
pp. 233-242 ◽  
Author(s):  
Bret E. Betz ◽  
Abul K. Azad ◽  
Jessica D. Morris ◽  
Murugesan V.S. Rajaram ◽  
Larry S. Schlesinger
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Intracellular Growth ◽  
Human Macrophages ◽  
Mycobacterium Bovis Bcg

scholarly journals CD40 Ligand (CD154) Does Not Contribute to Lymphocyte-Mediated Inhibition of Virulent Mycobacterium tuberculosis within Human Monocytes

2002 ◽  
Vol 70 (8) ◽  
pp. 4716-4720 ◽  
Author(s):  
Rhonda Larkin ◽  
Christopher D. Benjamin ◽  
Yen-Ming Hsu ◽  
Qing Li ◽  
Lynn Zukowski ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Peripheral Blood ◽  
Cd40 Ligand ◽  
Peripheral Blood Lymphocytes ◽  
Human Monocytes ◽  
Intracellular Growth ◽  
Soluble Cd40 Ligand ◽  
T Cell Lines

ABSTRACT Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood lymphocytes and antigen-specific CD4+ T-cell lines likewise was not reduced by blocking anti-CD40L monoclonal antibody 5c8.

scholarly journals Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence

2006 ◽  
Vol 60 (5) ◽  
pp. 1109-1122 ◽  
Author(s):  
Ernesto J. Munoz-Elias ◽  
Anna M. Upton ◽  
Joseph Cherian ◽  
John D. McKinney
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Intracellular Growth

Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosis

2001 ◽  
Vol 359 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Melania D'ORAZIO ◽  
Silvia FOLCARELLI ◽  
Francesca MARIANI ◽  
Vittorio COLIZZI ◽  
Giuseppe ROTILIO ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Mycobacterium Tuberculosis ◽  
Attachment Site ◽  
Gene Products ◽  
Lipid Modification ◽  
Negative Bacterium ◽  
Intracellular Growth ◽  
Sod Activity ◽  
Gram Positive Bacteria ◽  
Membrane Lipoprotein

The leader sequence of Mycobacterium tuberculosis Cu,Zn superoxide dismutase (Cu,ZnSOD) contains a prokaryotic membrane lipoprotein attachment site. In the present study, we have found that the protein, which exhibits detectable SOD activity, is lipid-modified and associated with the bacterial membrane when expressed either in M. tuberculosis or in Escherichia coli. These results provide the first demonstration of lipid modification of a Cu,ZnSOD. An analysis of the sodC genes present in available databases indicates that the same signal for lipid modification is also present in the sodC gene products from other mycobacteria and Gram-positive bacteria and, uniquely, in two distinct sodC gene products from the Gram-negative bacterium Salmonella typhimurium. Evidence is also provided for an up-regulation of M. tuberculosis sodC in response to phagocytosis by human macrophages, suggesting that Cu,ZnSOD is involved in the mechanisms that facilitate mycobacterial intracellular growth.

scholarly journals Glutathione and Nitrosoglutathione in Macrophage Defense against Mycobacterium tuberculosis

2005 ◽  
Vol 73 (3) ◽  
pp. 1886-1889 ◽  
Author(s):  
Vishwanath Venketaraman ◽  
Yaswant K. Dayaram ◽  
Meliza T. Talaue ◽  
Nancy D. Connell
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Intracellular Growth

ABSTRACT We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

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