scholarly journals Inhibiting the Programmed Death 1 Pathway Rescues Mycobacterium tuberculosis–Specific Interferon γ–Producing T Cells From Apoptosis in Patients With Pulmonary Tuberculosis

2013 ◽  
Vol 208 (4) ◽  
pp. 603-615 ◽  
Author(s):  
Amar Singh ◽  
Anant Mohan ◽  
Aparajit B. Dey ◽  
Dipendra K. Mitra
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Interferon Γ ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals T Cells from Programmed Death-1 Deficient Mice Respond Poorly to Mycobacterium tuberculosis Infection

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19864 ◽  
Author(s):  
Sultan Tousif ◽  
Yogesh Singh ◽  
Durbaka Vijaya Raghava Prasad ◽  
Pawan Sharma ◽  
Luc Van Kaer ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Deficient Mice

Programmed death 1 signaling on chronic myeloid leukemia–specific T cells results in T-cell exhaustion and disease progression

Blood ◽  
2009 ◽  
Vol 114 (8) ◽  
pp. 1528-1536 ◽  
Author(s):  
Sabine Mumprecht ◽  
Christian Schürch ◽  
Juerg Schwaller ◽  
Max Solenthaler ◽  
Adrian F. Ochsenbein
Keyword(s):  
T Cells ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Chronic Phase ◽  
Interferon Γ ◽  
Myeloproliferative Disease ◽  
Specific Ctls ◽  
Programmed Death ◽  
Programmed Death 1

Abstract Chronic myeloid leukemia (CML) is a malignant myeloproliferative disease with a characteristic chronic phase (cp) of several years before progression to blast crisis (bc). The immune system may contribute to disease control in CML. We analyzed leukemia-specific immune responses in cpCML and bcCML in a retroviral-induced murine CML model. In the presence of cpCML and bcCML expressing the glycoprotein of lymphocytic choriomeningitis virus as a model leukemia antigen, leukemia-specific cytotoxic T lymphocytes (CTLs) became exhausted. They maintained only limited cytotoxic activity, and did not produce interferon-γ or tumor necrosis factor-α or expand after restimulation. CML-specific CTLs were characterized by high expression of programmed death 1 (PD-1), whereas CML cells expressed PD-ligand 1 (PD-L1). Blocking the PD-1/PD-L1 interaction by generating bcCML in PD-1–deficient mice or by repetitive administration of αPD-L1 antibody prolonged survival. In addition, we found that PD-1 is up-regulated on CD8+ T cells from CML patients. Taken together, our results suggest that blocking the PD-1/PD-L1 interaction may restore the function of CML-specific CTLs and may represent a novel therapeutic approach for CML.

scholarly journals Programmed Death 1 and Cytokine Inducible SH2-Containing Protein Dependent Expansion of Regulatory T Cells Upon Stimulation With Mycobacterium tuberculosis

2011 ◽  
Vol 203 (9) ◽  
pp. 1256-1263 ◽  
Author(s):  
Sivakumar Periasamy ◽  
Rohan Dhiman ◽  
Peter F. Barnes ◽  
Padmaja Paidipally ◽  
Amy Tvinnereim ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Regulatory T Cells ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals Programmed death 1 is highly expressed on CD8+CD57+T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus

Immunology ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. 660-676 ◽  
Author(s):  
Maria T. Cencioni ◽  
Roberta Magliozzi ◽  
Richard Nicholas ◽  
Rehiana Ali ◽  
Omar Malik ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Cytotoxic Response ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Epstein Barr

scholarly journals Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma

2010 ◽  
Vol 23 (10) ◽  
pp. 1393-1403 ◽  
Author(s):  
Mei-Chi Hsu ◽  
Jenn-Ren Hsiao ◽  
Kung-Chao Chang ◽  
Yuan-Hua Wu ◽  
Ih-Jen Su ◽  
...  
Keyword(s):  
T Cells ◽  
Nasopharyngeal Carcinoma ◽  
Cd8 T Cells ◽  
Poor Prognosis ◽  
Programmed Death ◽  
Programmed Death 1

Corrigendum to ‘High-affinity human programmed death-1 ligand-1 variant promotes redirected T cells to kill tumor cells’ [Cancer Lett. 447 (2019) 164–173]

2019 ◽  
Vol 452 ◽  
pp. 268-269
Author(s):  
Zhaoduan Liang ◽  
Yanyan Li ◽  
Ye Tian ◽  
Huanling Zhang ◽  
Wenxuan Cai ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Cells ◽  
High Affinity ◽  
Programmed Death ◽  
Programmed Death 1

Expression of Programmed Death-1 (PD-1) on CD4+ and CD8+ T cells in Rheumatoid Arthritis

Inflammation ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Shufeng Li ◽  
Wensheng Liao ◽  
Meng Chen ◽  
Shiying Shan ◽  
Yuanlin Song ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Cd8 T Cells ◽  
Programmed Death ◽  
Programmed Death 1
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