scholarly journals Methamphetamine Alters Blood Brain Barrier Protein Expression in Mice, Facilitating Central Nervous System Infection by Neurotropic Cryptococcus neoformans

2013 ◽  
Vol 208 (4) ◽  
pp. 699-704 ◽  
Author(s):  
Eliseo A. Eugenin ◽  
Jade M. Greco ◽  
Susana Frases ◽  
Joshua D. Nosanchuk ◽  
Luis R. Martinez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Protein Expression ◽  
Cryptococcus Neoformans ◽  
Blood Brain Barrier ◽  
Central Nervous System Infection ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

2009 ◽  
Vol 8 (11) ◽  
pp. 1803-1807 ◽  
Author(s):  
Kiem Vu ◽  
Babette Weksler ◽  
Ignacio Romero ◽  
Pierre-Olivier Couraud ◽  
Angie Gelli
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endothelial Cell ◽  
Human Brain ◽  
Cell Line ◽  
Blood Brain Barrier ◽  
Central Nervous System Infection ◽  
Brain Barrier ◽  
Brain Endothelial Cell ◽  
Blood Brain

ABSTRACT Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

scholarly journals Central nervous system delivery of molecules across the blood-brain barrier

2021 ◽  
pp. 104952
Author(s):  
Fabien Gosselet ◽  
Rodrigo Azevedo Loiola ◽  
Anna Roig ◽  
Anna Rosell ◽  
Maxime Culot
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models

Physiology ◽  
1998 ◽  
Vol 13 (6) ◽  
pp. 287-293 ◽  
Author(s):  
Gerald A. Grant ◽  
N. Joan Abbott ◽  
Damir Janigro
Keyword(s):  
Central Nervous System ◽  
Tissue Culture ◽  
Nervous System ◽  
Blood Brain Barrier ◽  
In Vitro Models ◽  
Brain Barrier ◽  
Blood Brain ◽  
Brain Tissue Culture ◽  
The Brain

Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.

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